HUS1

HUS1 checkpoint homolog (S. pombe)

Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

HUS1 (6)

Publications

No (6)

Tag

GST (1)

His (1)

His-SUMO (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human HUS1 Protein (Recombinant His) - LS-G1035

Source:

E. coli

Tag:

His

Price:

10 µg/$361; 50 µg/$739

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Human HUS1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68374

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

31.5 kDa

Price:

20 µg/$1,107

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Human HUS1 Protein (Recombinant His-SUMO) (Full Length) - LS-G20836

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

47.5 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human HUS1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82035

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

31.5 kDa

Price:

20 µg/$150

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HUS1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100319

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

31.5 kDa

Price:

100 µg/$494

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Human HUS1 Protein (Recombinant GST) (Full Length) - LS-G28954

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

56.54 kDa

Price:

10 µg/$479; 25 µg/$670

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