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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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HTT / Huntingtin

huntingtin

Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression.

Gene Name: huntingtin
Family/Subfamily: Hungtintin , Not assigned-Other
Synonyms: HTT, Huntingtin, Huntington disease protein, IT15, HD, HD protein
Target Sequences: NM_002111 NP_002102.4 P42858

Publications (2)

1
Inhibition of apoptosis signal-regulating kinase 1 reduces endoplasmic reticulum stress and nuclear huntingtin fragments in a mouse model of Huntington disease. Cho KJ, Lee BI, Cheon SY, Kim HW, Kim HJ, Kim GW. Neuroscience. 2009 163:1128-34. (IHC, WB) [PubMed:19646509]
2
Adeno-Associated Viral Vector Serotype DJ-Mediated Overexpression of N171-82Q-Mutant Huntingtin in the Striatum of Juvenile Mice Is a New Model for Huntington's Disease. Jang M, Lee SE, Cho IH. Frontiers in cellular neuroscience. 2018 June;12:157. (Human) [Full Text Article] [PubMed:29946240] [PMC:PMC6005874] Related Antibodies: LS-C24591.

Filtered by: None
Type
Over-Expression Lysate (2)
Recombinant (2)
Target
HTT / Huntingtin (4)
Tag
GST,N-terminus (1)
His + GST (1)
Myc + DDK (2)
Species
Human (2)
Mouse (1)
Source
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purification
Purified (1)
Publications
No (4)
Showing 1-4 of 4 results

HTT / Huntingtin Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G118183
HEK 293 Cells
Myc + DDK
347.7 kDa
100µg  $485.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human HTT / Huntingtin Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G76624
293T Cells
Myc + DDK
347.7 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human HTT / Huntingtin Protein (Recombinant GST,N-terminus) (aa81-190) - LS-G58828
Wheat Germ Extract
GST,N-terminus
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE Stained with Coomassie Blue.

Mouse HTT / Huntingtin Protein (Recombinant His + GST) (aa782-920) - LS-G15973
E. coli
His + GST
48.1 kDa
10µg  $275.00; 50µg  $445.00; 100µg  $575.00; 200µg  $845.00; 1mg  $2,160.00; 500µg  $965.00
Recombinant Huntingtin By SDS-PAGE
Showing 1-4 of 4 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).