HTT / Huntingtin

huntingtin

Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

HTT / Huntingtin (5)

Publications

No (5)

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GST, N-terminus (1)

His-GST (1)

Myc-DDK (Flag) (2)

Myc-DDK (Flag), C-terminus (1)

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Human (3)

Mouse (1)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human HTT / Huntingtin Protein (Recombinant Myc-DDK (Flag), C-terminus) (Full Length) - LS-G142152

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag), C-terminus

Molecular Weight:

347.7 kDa

Price:

20 µg/$1,107

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HTT / Huntingtin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118183

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

347.7 kDa

Price:

100 µg/$710

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Human HTT / Huntingtin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76624

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

347.7 kDa

Price:

20 µg/$215

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Human HTT / Huntingtin Protein (Recombinant GST, N-terminus) (aa81-190) - LS-G58828

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Mouse HTT / Huntingtin Protein (Recombinant His-GST) (aa782-920) - LS-G15973

Source:

E. coli

Tag:

His-GST

Molecular Weight:

48.1 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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