HTT / Huntingtin

huntingtin

Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression.

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Products

ELISA Kits (9)

Type

Competitive EIA (1)

Custom (1)

Sandwich (7)

Target

HTT / Huntingtin (9)

Reactivity

Human (4)

Mouse (3)

Rat (2)

Format

96-Well Strip Plate (9)

Publications

No (9)

Sample Type

Brain Cell Lysates (1)

Cell Lysates (2)

Plasma (4)

Serum (5)

Tissue Homogenates (5)

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Human HTT / Huntingtin (Sandwich ELISA) ELISA Kit - LS-F7108

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

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Human HTT / Huntingtin (Sandwich ELISA) ELISA Kit - LS-F11614

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Mouse HTT / Huntingtin (Sandwich ELISA) ELISA Kit - LS-F11615

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Serum

Price:

1 Plate/$783

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Human HTT / Huntingtin (Sandwich ELISA) ELISA Kit - LS-F52063

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

12.5 - 800 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$958

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Mouse HTT / Huntingtin (Sandwich ELISA) ELISA Kit - LS-F34723

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Brain Cell Lysates, Tissue Homogenates

Price:

1 Plate/$579

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Mouse HTT / Huntingtin (Sandwich ELISA) ELISA Kit - LS-F7267

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$854

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Rat HTT / Huntingtin (Custom ELISA) ELISA Kit - LS-F16268

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Human HTT / Huntingtin (Competitive EIA) ELISA Kit - LS-F39296

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat HTT / Huntingtin (Sandwich ELISA) ELISA Kit - LS-F7268

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$893

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