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HTRA4 is a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging.
Gene Name: | HtrA serine peptidase 4 |
Family/Subfamily: | Protease , Serine S1C |
Synonyms: | HTRA4, Serine protease HTRA4, Probable serine protease HTRA4, HtrA serine peptidase 4 |
Target Sequences: | AK075205 P83105 P83105 |
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