HTRA2 / OMI

HtrA serine peptidase 2

Inhibitor of apoptosis proteins (IAPs) were initially identified in baculoviruses as proteins that inhibit apoptosis of the host cells to allow time for viral replication. Cellular homologues containing at least one baculoviral IAP repeat (BIR) motif essential for their anti-apoptosis activity have been identified in yeasts and higher organisms and often act by binding and inhibiting processed caspases. The activity of these proteins can be modulated by the expression of proteins such as Smac/DIABLO and XAF-1 which displace or prevent the binding of caspases by IAPs. Recently, a mitochondrial serine protease termed Omi/HtrA2 has been found to bind IAPs. Similar to Smac, Omi possesses a conserved IAP-binding motif, but acts to cleave IAPs to irreversibly inactivate IAPs and promote apoptosis.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

HTRA2 / OMI (8)

Publications

No (8)

Tag

6His, C-terminus (2)

6His, N-terminus (1)

GST, N-terminus (1)

His, C-Terminal (1)

His,C-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (7)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (1)

Human Cells (1)

Mammalian Cells (1)

Wheat Germ Extract (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (2)

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Human HTRA2 / OMI Protein (Recombinant GST, N-terminus) (aa359-458) - LS-G62282

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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HTRA2 / OMI Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G106764

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38.3 kDa

Price:

100 µg/$494

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Human HTRA2 / OMI Protein (Recombinant His, C-Terminal) - LS-G3454

Source:

E. coli

Tag:

His, C-Terminal

Price:

100 µg/$317; 500 µg/$526; 20 µg/$245

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Human HTRA2 / OMI Protein (Recombinant 6His, C-terminus) (Ala134-Glu458) - LS-G39157

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

36kD

Price:

10 µg/$248; 50 µg/$288; 500 µg/$785; 1 mg/$1,203

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Human HTRA2 / OMI Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89025

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38.3 kDa

Price:

20 µg/$150

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Human HTRA2 / OMI Protein (Recombinant 6His, N-terminus) (Ala134-Glu458) - LS-G26627

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

37 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365

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Human HTRA2 / OMI Protein (Recombinant 6His, C-terminus) (Ala134-Glu458) - LS-G138798

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

36.0 kDa

Price:

10 µg/$336; 50 µg/$376

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Human HTRA2 / OMI Protein (Recombinant His,C-terminus) (Ala134-Glu458) - LS-G138478

Source:

E. coli

Tag:

His,C-terminus

Price:

100 µg/$793

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