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HTRA2 / OMI

HtrA serine peptidase 2

Inhibitor of apoptosis proteins (IAPs) were initially identified in baculoviruses as proteins that inhibit apoptosis of the host cells to allow time for viral replication. Cellular homologues containing at least one baculoviral IAP repeat (BIR) motif essential for their anti-apoptosis activity have been identified in yeasts and higher organisms and often act by binding and inhibiting processed caspases. The activity of these proteins can be modulated by the expression of proteins such as Smac/DIABLO and XAF-1 which displace or prevent the binding of caspases by IAPs. Recently, a mitochondrial serine protease termed Omi/HtrA2 has been found to bind IAPs. Similar to Smac, Omi possesses a conserved IAP-binding motif, but acts to cleave IAPs to irreversibly inactivate IAPs and promote apoptosis.

Gene Name: HtrA serine peptidase 2
Family/Subfamily: Protease , Serine S1C
Synonyms: HTRA2, HtrA-like serine protease, OMI, PARK13, Protease, serine, 25, PRSS25, Serine protease 25, HtrA serine peptidase 2, Serine proteinase OMI
Target Sequences: NM_013247 NP_037379.1 O43464

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Products
Proteins (8)
Over-Expression Lysate (2)
Recombinant (6)
HTRA2 / OMI (8)
No (8)
6His, C-terminus (2)
6His, N-terminus (1)
GST, N-terminus (1)
His, C-Terminal (1)
His,C-terminus (1)
Myc-DDK (Flag) (2)
Human (7)
293T Cells (1)
E. coli (3)
HEK 293 Cells (1)
Human Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (2)
HTRA2 / OMI Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
HTRA2 / OMI Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
38.3 kDa
100 µg/$494
HTRA2 / OMI Protein
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E. coli
His, C-Terminal
100 µg/$317; 500 µg/$526; 20 µg/$245
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36kD
10 µg/$248; 50 µg/$288; 500 µg/$785; 1 mg/$1,203
HTRA2 / OMI Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
38.3 kDa
20 µg/$150
HTRA2 / OMI Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
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E. coli
6His, N-terminus
37 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
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Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.0 kDa
10 µg/$336; 50 µg/$376
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Viewing 1-8 of 8 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).