HTRA1

HtrA serine peptidase 1

Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.

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Products

Proteins (10)

Type

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (3)

Recombinant (6)

Target

HTRA1 (10)

Publications

No (10)

Tag

6His, N-terminus (2)

6His-SUMO, N-terminus (1)

His (2)

His-GST (1)

Myc-DDK (Flag) (3)

Myc-DDK (Flag), C-terminus (1)

Species

E. coli (2)

Human (5)

Mouse (2)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (5)

Purification

Purified (1)

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Mouse HTRA1 Protein (Over-Expression Cell Culture Supernatant 6His, N-terminus) (Leu23-Pro480) - LS-G26823

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

49 kDa

Price:

200 µl/$283

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Mouse HTRA1 Protein (Over-Expression Lysate 6His, N-terminus) (Leu23-Pro480) - LS-G26674

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

49 kDa

Price:

100 µg/$298

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Human HTRA1 Protein (Recombinant 6His-SUMO, N-terminus) (aa23-480) - LS-G56837

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human HTRA1 Protein (Recombinant His-GST) (aa204-364) - LS-G16145

Source:

E. coli

Tag:

His-GST

Molecular Weight:

49.1 kDa

Price:

10 µg/$299; 50 µg/$552; 100 µg/$882; 200 µg/$1,080; 1 mg/$2,261; 500 µg/$1,775; 5 mg/$3,851; 2 mg/$2,453

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Human HTRA1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67943

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49 kDa

Price:

20 µg/$1,107

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Human HTRA1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81038

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.53 kDa

Price:

20 µg/$215

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E. coli HTRA1 Protein (Recombinant His) (aa10-146) - LS-G16140

Source:

E. coli

Tag:

His

Molecular Weight:

15.7 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human HTRA1 Protein (Recombinant Myc-DDK (Flag), C-terminus) - LS-G142252

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag), C-terminus

Molecular Weight:

49 kDa

Price:

20 µg/$1,107

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HTRA1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99866

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.53 kDa

Price:

100 µg/$710

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E. coli HTRA1 Protein (Recombinant His) (aa304-442) - LS-G16143

Source:

E. coli

Tag:

His

Molecular Weight:

15.5 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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