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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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HTR4 / 5-HT4 Receptor

5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled

The 5-HT4 receptor, a member of the Serotonin Receptor subfamily, has been shown to affect the sensory and motor functions of the gut. Some of the most promising emerging therapies in Irritable Bowel Syndrome revolve around targeted pharmacotherapeutic modulation of serotonin receptors (ie, 5-HT3 and 5-HT4 subtypes). At least 9 isoforms (5-HT4A-5-HT4G, and 5-HT4n) have been described, which differ in the length and composition of their intracellular C termini after a common splicing site (L358). A ninth isoform (5-HT4H) results in the insertion of 14 amino acids into the second intracellular loop.

Gene Name: 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
Family/Subfamily: GPCR , Serotonin
Synonyms: HTR4, 5-HT4, 5-HT4R, 5-HT-4, 5HT4 receptor, 5-HT4 receptor, 5-hydroxytryptamine 4 receptor, 5-hydroxytryptamine receptor 4, Serotonin 5-HT-4a receptor, Serotonin receptor 4, Cardiac 5-HT4 receptor, Serotonin 4 receptor, Serotonin 5-HT-4 receptor
Target Sequences: NM_000870 NP_000861.1 Q13639

Publications (2)

1
Role of cAMP/PKA pathway and T-type calcium channels in the mechanism of action of serotonin in human adrenocortical cells. Louiset E, Duparc C, Lenglet S, Gomez-Sanchez CE, Lefebvre H. Molecular and cellular endocrinology. 2017 February;441:99-107. (Human) [Full Text Article] [PubMed:27743992] [PMC:PMC5465225] Related Antibodies: LS-A2685.
2
Illicit Upregulation of Serotonin Signaling Pathway in Adrenals of Patients With High Plasma or Intra-Adrenal ACTH Levels. Le Mestre J, Duparc C, Reznik Y, Bonnet-Serrano F, Touraine P, Chabre O, Young J, Suzuki M, Sibony M, Gobet F, Stratakis CA, Raverot G, Bertherat J, Lefebvre H, Louiset E. The Journal of clinical endocrinology and metabolism. 2019 November;104:4967-4980. [Full Text Article] [PubMed:31074783] [PMC:PMC6937520] Related Antibodies: LS-A2685.


HTR4 / 5-HT4 Receptor Antibody - Anti-HTR4 / 5-HT4 Receptor antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Rabbit, Dog, Bovine, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
HTR4 / 5-HT4 Receptor Antibody - Anti-HTR4 / 5-HT4 Receptor antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Rabbit, Dog, Bovine, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
HTR4 / 5-HT4 Receptor Antibody - Anti-HTR4 / 5-HT4 Receptor antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Rabbit, Dog, Bovine, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl   $650.00
HTR4 / 5-HT4 Receptor Antibody - Anti-HTR4 / 5-HT4 Receptor antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Rabbit, Dog, Bovine, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
AP Conjugated
100µl   $650.00
HTR4 / 5-HT4 Receptor Antibody - Anti-HTR4 / 5-HT4 Receptor antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Rabbit, Dog, Bovine, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
APC Conjugated
100µl   $650.00
HTR4 / 5-HT4 Receptor Antibody - Anti-HTR4 / 5-HT4 Receptor antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Rabbit, Dog, Bovine, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
PE Conjugated
100µl   $650.00
HTR4 / 5-HT4 Receptor Antibody - Anti-HTR4 / 5-HT4 Receptor antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Rabbit, Dog, Bovine, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
HTR4 / 5-HT4 Receptor Antibody - Anti-5HT4 Receptor antibody IHC of human brain, medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Neuroscience
Fast Shipping
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Human, Monkey
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
HTR4 / 5-HT4 Receptor Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Fast Shipping
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
HTR4 / 5-HT4 Receptor Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Fast Shipping
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl   $650.00
HTR4 / 5-HT4 Receptor Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Fast Shipping
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Human, Monkey
IHC, IHC-P
AP Conjugated
100µl   $650.00
HTR4 / 5-HT4 Receptor Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Fast Shipping
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Human, Monkey
IHC, IHC-P
PE Conjugated
100µl   $650.00
HTR4 / 5-HT4 Receptor Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Fast Shipping
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Human, Monkey
IHC, IHC-P
APC Conjugated
100µl   $650.00
HTR4 / 5-HT4 Receptor Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Fast Shipping
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
HTR4 / 5-HT4 Receptor Antibody - Anti-5HT4 Receptor antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Rabbit, Dog, Guinea pig, Bovine, Hamster, Horse, Bat, Human
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
HTR4 / 5-HT4 Receptor Antibody - Anti-5HT4 Receptor antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Rabbit, Dog, Guinea pig, Bovine, Hamster, Horse, Bat, Human
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
HTR4 / 5-HT4 Receptor Antibody - Anti-5HT4 Receptor antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Rabbit, Dog, Guinea pig, Bovine, Hamster, Horse, Bat, Human
IHC, IHC-P
FITC Conjugated
100µl   $650.00
HTR4 / 5-HT4 Receptor Antibody - Anti-5HT4 Receptor antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Rabbit, Dog, Guinea pig, Bovine, Hamster, Horse, Bat, Human
IHC, IHC-P
AP Conjugated
100µl   $650.00
HTR4 / 5-HT4 Receptor Antibody - Anti-5HT4 Receptor antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Rabbit, Dog, Guinea pig, Bovine, Hamster, Horse, Bat, Human
IHC, IHC-P
APC Conjugated
100µl   $650.00
HTR4 / 5-HT4 Receptor Antibody - Anti-5HT4 Receptor antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Rabbit, Dog, Guinea pig, Bovine, Hamster, Horse, Bat, Human
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
HTR4 / 5-HT4 Receptor Antibody - Anti-5HT4 Receptor antibody IHC of human brain, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Pig, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
HTR4 / 5-HT4 Receptor Antibody - Anti-5HT4 Receptor antibody IHC of human brain, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Pig, Horse, Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
HTR4 / 5-HT4 Receptor Antibody - Anti-5HT4 Receptor antibody IHC of human brain, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Pig, Horse, Human, Monkey
IHC, IHC-P
PE Conjugated
100µl   $650.00
HTR4 / 5-HT4 Receptor Antibody - Anti-5HT4 Receptor antibody IHC of human brain, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Pig, Horse, Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
HTR4 / 5-HT4 Receptor Antibody - Anti-5HT4 Receptor antibody IHC of human brain, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human HTR4 / 5-HT4 Receptor
Pig, Horse, Human, Monkey
IHC, IHC-P
AP Conjugated
100µl   $650.00
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).