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HTR2C / 5-HT2C Receptor

5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.

Gene Name: 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
Family/Subfamily: GPCR , Serotonin
Synonyms: HTR2C, 5-HT-1C, 5-HT1c receptor, 5HT-1C, 5-HT2C, 5-HT2c receptor, 5HT2C Receptor, 5-HT-2C, 5-HT1C, 5-HTR2C, HTR1C, Serotonin 5-HT-1c receptor, Serotonin receptor 2C, Serotonin 1c receptor, Serotonin 5-HT-2C receptor, Serotonin 2c receptor
Target Sequences: nm_000868 NP_000859.1 P28335

Publications (3)

1
Human polyomavirus receptor distribution in brain parenchyma contrasts with receptor distribution in kidney and choroid plexus. Haley SA, O'Hara BA, Nelson CD, Brittingham FL, Henriksen KJ, Stopa EG, Atwood WJ. The American journal of pathology. 2015 August;185:2246-58. (Human) [Full Text Article] [PubMed:26056932] [PMC:PMC4530127] Related Antibodies: LS-A1119.
2
Effects of Jian-Pi-Zhi-Dong Decoction on the Expression of 5-HT and Its Receptor in a Rat Model of Tourette Syndrome and Comorbid Anxiety. Dan Wang, Hui-Ling Tian, Xia Cui, Qian Wang, Fan Guo, Wen Zhang, Qi-Sheng Tang. Medical science monitor : international medical journal of experimental and clinical research. 2020 August;26:e924658. [Full Text Article] [PubMed:32738135] [PMC:PMC7416613] Related Antibodies: LS-B11334.
3
Functional constipation induces bladder overactivity associated with upregulations of Htr2 and Trpv2 pathways. Nao Iguchi, Alonso Carrasco Jr, Alison X Xie, Ricardo H Pineda, Anna P Malykhina, Duncan T Wilcox. Scientific reports. 2021 January;11:1149. [Full Text Article] [PubMed:33441874] [PMC:PMC7806916] Related Antibodies: LS-C386171.

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Proteins (3)
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HTR2C / 5-HT2C Receptor (3)
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HTR2C / 5-HT2C Receptor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
51.6 kDa
100 µg/$710
HTR2C / 5-HT2C Receptor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
51.6 kDa
20 µg/$215
HTR2C / 5-HT2C Receptor Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).