HSPG2 / Perlecan

heparan sulfate proteoglycan 2

Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development.Endorepellin in an anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6.The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity.

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Products

Proteins (3)

Type

Over-Expression Lysate (1)

Recombinant (2)

Target

HSPG2 / Perlecan (3)

Publications

No (3)

Tag

GST, N-terminus (1)

His, N-Terminal (1)

Myc-DDK (Flag) (1)

Species

Human (2)

Source

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human HSPG2 / Perlecan Protein (Recombinant His, N-Terminal) (Leu4149-Ser4391) - LS-G15034

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

27.0 kDa

Price:

10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934

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HSPG2 / Perlecan Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115909

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

468.91 kDa

Price:

100 µg/$710

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Human HSPG2 / Perlecan Protein (Recombinant GST, N-terminus) (aa25-134) - LS-G58912

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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