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HSPB1 / HSP27

heat shock 27kDa protein 1

Heat shock protein 27 (Hsp27) also known as heat shock protein beta-1 (HSPB1) is a protein that in humans is encoded by the HSPB1 gene. Hsp27 is a chaperone of the sHsp (small heat shock protein) group among ubiquitin, a-crystallin, Hsp20 and others. The common functions of sHsps are chaperone activity, thermotolerance, inhibition of apoptosis, regulation of cell development, and cell differentiation. They also take part in signal transduction.

Gene Name: heat shock 27kDa protein 1
Synonyms: HSPB1, 28 kDa heat shock protein, Heat shock 27 kDa protein, Heat shock 27kD protein 1, Heat shock 27kDa protein 1, HSP27, HSP28, HSP 27, Hsp25, SRP27, Stress-responsive protein 27, CMT2F, Heat shock 27 kd protein, Heat shock protein beta-1, HMN2B, HS.76067
Target Sequences: NM_001540 NP_001531.1 P04792

Publications (10)

1
Chromosomal assignments of human 27-kDa heat shock protein gene family. McGuire SE, Fuqua SA, Naylor SL, Helin-Davis DA, McGuire WL. Somatic cell and molecular genetics. 1989 15:167-71. [PubMed:2538929] Related Antibodies: LS-B383.
2
Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function. Booth L, Shuch B, Albers T, Roberts JL, Tavallai M, Proniuk S, Zukiwski A, Wang D, Chen CS, Bottaro D, Ecroyd H, Lebedyeva IO, Dent P. Oncotarget. 2016 7:12975-96. (WB; Human) [Full Text Article] [PubMed:26887051] [PMC:PMC4914336] Related Antibodies: LS-C31836.
3
Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function. Unger A, Beckendorf L, Böhme P, Kley R, von Frieling-Salewsky M, Lochmüller H, Schröder R, Fürst DO, Vorgerd M, Linke WA. Acta neuropathologica communications. 2017 5:72. (WB; Human) [Full Text Article] [PubMed:28915917] [PMC:PMC5603016]
4
A cDNA for the estradiol-regulated 24K protein: control of mRNA levels in MCF-7 cells. Moretti-Rojas I, Fuqua SA, Montgomery RA, McGuire WL. Breast cancer research and treatment. 1988 11:155-63. [PubMed:3401605] Related Antibodies: LS-B383.
5
Estradiol stimulates synthesis of a major intracellular protein in a human breast cancer cell line (MCF-7). Edwards DP, Adams DJ, McGuire WL. Breast cancer research and treatment. 1981 1:209-23. [PubMed:7348573] Related Antibodies: LS-B383.
6
Rationally Repurposing Ruxolitinib (Jakafi (®)) as a Solid Tumor Therapeutic. Tavallai M, Booth L, Roberts JL, Poklepovic A, Dent P. Frontiers in oncology. 2016 6:142. (WB; Human) [Full Text Article] [PubMed:27379204] [PMC:PMC4904019] Related Antibodies: LS-C31836.
7
[Pemetrexed + Sorafenib] lethality is increased by inhibition of ERBB1/2/3-PI3K-NF?B compensatory survival signaling. Booth L, Roberts JL, Tavallai M, Chuckalovcak J, Stringer DK, Koromilas AE, Boone DL, McGuire WP, Poklepovic A, Dent P. Oncotarget. 2016 7:23608-32. (WB; Human) [Full Text Article] [PubMed:27015562] [PMC:PMC5029651] Related Antibodies: LS-C31836.
8
Multi-kinase inhibitors interact with sildenafil and ERBB1/2/4 inhibitors to kill tumor cells in vitro and in vivo. Booth L, Albers T, Roberts JL, Tavallai M, Poklepovic A, Lebedyeva IO, Dent P. Oncotarget. 2016 7:40398-40417. (WB; Human) [Full Text Article] [PubMed:27259258] [PMC:PMC5130016] Related Antibodies: LS-C31836.
9
PDE5 inhibitors enhance the lethality of pemetrexed through inhibition of multiple chaperone proteins and via the actions of cyclic GMP and nitric oxide. Booth L, Roberts JL, Poklepovic A, Gordon S, Dent P. Oncotarget. 2017 8:1449-1468. (WB; Human) [Full Text Article] [PubMed:27903966] [PMC:PMC5352068] Related Antibodies: LS-C31836.
10
The HDAC inhibitor AR42 interacts with pazopanib to kill trametinib/dabrafenib-resistant melanoma cells in vitro and in vivo. Booth L, Roberts JL, Sander C, Lee J, Kirkwood JM, Poklepovic A, Dent P. Oncotarget. 2017 8:16367-16386. (WB; Human) [Full Text Article] [PubMed:28146421] [PMC:PMC5369969] Related Antibodies: LS-C31836.
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Products
Proteins (16)
Over-Expression Lysate (2)
Recombinant (13)
HSPB1 / HSP27 (16)
No (16)
6His, N-terminus (1)
GST (1)
GST, N-terminus (1)
His (7)
Myc-DDK (Flag) (3)
Bovine (1)
Human (13)
Mouse (1)
293T Cells (1)
E. coli (11)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (5)
Low endotoxin level (3)
Select
Human HSPB1 / HSP27 Protein - LS-G134045
E. coli
None
22.7 kDa
10 µg/$329; 50 µg/$412; 1000 µg/$2,488
HSPB1 / HSP27 Protein - Purified recombinant protein HSPB1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
Human HSPB1 / HSP27 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G64783
HEK 293 Cells
Myc-DDK (Flag)
22.6 kDa
20 µg/$1,107
HSPB1 / HSP27 Protein - SDS-PAGE of 28kDa Hsp27 protein.
Select
Human HSPB1 / HSP27 Protein (Recombinant His) - LS-G141256
E. coli
His
50 µg/$307; 100 µg/$372
HSPB1 / HSP27 Protein - SDS-PAGE of 27kDa native human Hsp27 protein.
Select
Human HSPB1 / HSP27 Protein (Recombinant) (Full Length) - LS-G141265
E. coli
None
50 µg/$316; 100 µg/$396
HSPB1 / HSP27 Protein - 12.5% SDS-PAGE of human HSPB1 stained with Coomassie Blue
Select
Human HSPB1 / HSP27 Protein (Recombinant GST) (Full Length) - LS-G28939
Wheat Germ Extract
GST
49.2 kDa
10 µg/$479; 25 µg/$670
HSPB1 / HSP27 Protein - Recombinant Heat Shock 27kDa Protein 1 By SDS-PAGE
Select
Bovine HSPB1 / HSP27 Protein (Recombinant His) (aa1-201) - LS-G24088
E. coli
His
26.1 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
Select
Human HSPB1 / HSP27 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74181
293T Cells
Myc-DDK (Flag)
22.6 kDa
20 µg/$150
HSPB1 / HSP27 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Human HSPB1 / HSP27 Protein (Recombinant GST, N-terminus) (aa96-205) - LS-G58913
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
HSPB1 / HSP27 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HSPB1 / HSP27 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99471
HEK 293 Cells
Myc-DDK (Flag)
22.6 kDa
100 µg/$494
Select
Human HSPB1 / HSP27 Protein (Recombinant His) (Met1-Lys205) - LS-G97547
E. coli
His
28 kDa
100 µg/$721
Select
Human HSPB1 / HSP27 Protein (Recombinant His) (aa1-205) - LS-G140962
E. coli
105 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
22.55 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
HSPB1 / HSP27 Protein
Select
Human HSPB1 / HSP27 Protein (Recombinant) - LS-G3453
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$317; 500 µg/$526; 20 µg/$245
HSPB1 / HSP27 Protein
Select
Human HSPB1 / HSP27 Protein (Recombinant His) - LS-G683
E. coli
His
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$342; 500 µg/$641; 20 µg/$254
HSPB1 / HSP27 Protein
Select
Human HSPB1 / HSP27 Protein (Recombinant 6His, N-terminus) (Thr2-Lys205) - LS-G26504
E. coli
6His, N-terminus
24.9 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365; 500 µg/$949
HSPB1 / HSP27 Protein - Recombinant Heat Shock 27kDa Protein 1 By SDS-PAGE
Select
Mouse HSPB1 / HSP27 Protein (Recombinant His) (aa1-209) - LS-G12672
E. coli
His
24.5 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
HSPB1 / HSP27 Protein - Recombinant Heat Shock 27kDa Protein 1 By SDS-PAGE
Select
Human HSPB1 / HSP27 Protein (Recombinant His) (aa2-205) - LS-G12675
E. coli
His
23.9 kDa
10 µg/$255; 50 µg/$323; 100 µg/$450; 200 µg/$562; 1 mg/$1,480; 500 µg/$1,096; 5 mg/$2,395; 2 mg/$1,646
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