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HSPB1 / HSP27

heat shock 27kDa protein 1

Heat shock protein 27 (Hsp27) also known as heat shock protein beta-1 (HSPB1) is a protein that in humans is encoded by the HSPB1 gene. Hsp27 is a chaperone of the sHsp (small heat shock protein) group among ubiquitin, a-crystallin, Hsp20 and others. The common functions of sHsps are chaperone activity, thermotolerance, inhibition of apoptosis, regulation of cell development, and cell differentiation. They also take part in signal transduction.

Gene Name: heat shock 27kDa protein 1
Synonyms: HSPB1, 28 kDa heat shock protein, Heat shock 27 kDa protein, Heat shock 27kD protein 1, Heat shock 27kDa protein 1, HSP27, HSP28, HSP 27, Hsp25, SRP27, Stress-responsive protein 27, CMT2F, Heat shock 27 kd protein, Heat shock protein beta-1, HMN2B, HS.76067
Target Sequences: NM_001540 NP_001531.1 P04792

Publications (10)

1
Chromosomal assignments of human 27-kDa heat shock protein gene family. McGuire SE, Fuqua SA, Naylor SL, Helin-Davis DA, McGuire WL. Somatic cell and molecular genetics. 1989 15:167-71. [PubMed:2538929] Related Antibodies: LS-B383.
2
Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function. Booth L, Shuch B, Albers T, Roberts JL, Tavallai M, Proniuk S, Zukiwski A, Wang D, Chen CS, Bottaro D, Ecroyd H, Lebedyeva IO, Dent P. Oncotarget. 2016 7:12975-96. (WB; Human) [Full Text Article] [PubMed:26887051] [PMC:PMC4914336] Related Antibodies: LS-C31836.
3
Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function. Unger A, Beckendorf L, Böhme P, Kley R, von Frieling-Salewsky M, Lochmüller H, Schröder R, Fürst DO, Vorgerd M, Linke WA. Acta neuropathologica communications. 2017 5:72. (WB; Human) [Full Text Article] [PubMed:28915917] [PMC:PMC5603016]
4
A cDNA for the estradiol-regulated 24K protein: control of mRNA levels in MCF-7 cells. Moretti-Rojas I, Fuqua SA, Montgomery RA, McGuire WL. Breast cancer research and treatment. 1988 11:155-63. [PubMed:3401605] Related Antibodies: LS-B383.
5
Estradiol stimulates synthesis of a major intracellular protein in a human breast cancer cell line (MCF-7). Edwards DP, Adams DJ, McGuire WL. Breast cancer research and treatment. 1981 1:209-23. [PubMed:7348573] Related Antibodies: LS-B383.
6
Rationally Repurposing Ruxolitinib (Jakafi (®)) as a Solid Tumor Therapeutic. Tavallai M, Booth L, Roberts JL, Poklepovic A, Dent P. Frontiers in oncology. 2016 6:142. (WB; Human) [Full Text Article] [PubMed:27379204] [PMC:PMC4904019] Related Antibodies: LS-C31836.
7
[Pemetrexed + Sorafenib] lethality is increased by inhibition of ERBB1/2/3-PI3K-NF?B compensatory survival signaling. Booth L, Roberts JL, Tavallai M, Chuckalovcak J, Stringer DK, Koromilas AE, Boone DL, McGuire WP, Poklepovic A, Dent P. Oncotarget. 2016 7:23608-32. (WB; Human) [Full Text Article] [PubMed:27015562] [PMC:PMC5029651] Related Antibodies: LS-C31836.
8
Multi-kinase inhibitors interact with sildenafil and ERBB1/2/4 inhibitors to kill tumor cells in vitro and in vivo. Booth L, Albers T, Roberts JL, Tavallai M, Poklepovic A, Lebedyeva IO, Dent P. Oncotarget. 2016 7:40398-40417. (WB; Human) [Full Text Article] [PubMed:27259258] [PMC:PMC5130016] Related Antibodies: LS-C31836.
9
PDE5 inhibitors enhance the lethality of pemetrexed through inhibition of multiple chaperone proteins and via the actions of cyclic GMP and nitric oxide. Booth L, Roberts JL, Poklepovic A, Gordon S, Dent P. Oncotarget. 2017 8:1449-1468. (WB; Human) [Full Text Article] [PubMed:27903966] [PMC:PMC5352068] Related Antibodies: LS-C31836.
10
The HDAC inhibitor AR42 interacts with pazopanib to kill trametinib/dabrafenib-resistant melanoma cells in vitro and in vivo. Booth L, Roberts JL, Sander C, Lee J, Kirkwood JM, Poklepovic A, Dent P. Oncotarget. 2017 8:16367-16386. (WB; Human) [Full Text Article] [PubMed:28146421] [PMC:PMC5369969] Related Antibodies: LS-C31836.
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ELISA Kits (36)
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HSPB1 / HSP27 (36)
Human (13)
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96-Well Microplate (10)
96-Well Strip Plate (23)
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Cell Culture Supernatants (8)
Cell Lysates (8)
Plasma (24)
Serum (24)
Tissue Homogenates (11)
HSPB1 / HSP27 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
HSPB1 / HSP27 ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$772
HSPB1 / HSP27 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$818
HSPB1 / HSP27 ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
HSPB1 / HSP27 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$685
HSPB1 / HSP27 ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$627
HSPB1 / HSP27 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$627
HSPB1 / HSP27 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$627
HSPB1 / HSP27 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$627
HSPB1 / HSP27 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
HSPB1 / HSP27 ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
HSPB1 / HSP27 ELISA Kit
Select
Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$929
HSPB1 / HSP27 ELISA Kit
Select
Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$783
HSPB1 / HSP27 ELISA Kit
Select
Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$929
HSPB1 / HSP27 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$685
HSPB1 / HSP27 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Bovine
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
HSPB1 / HSP27 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
0.156 - 10 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
HSPB1 / HSP27 ELISA Kit
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Sandwich
96-Well Microplate
Pig
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$627
HSPB1 / HSP27 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$626
HSPB1 / HSP27 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$717
HSPB1 / HSP27 ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
HSPB1 / HSP27 ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$626
HSPB1 / HSP27 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$626
HSPB1 / HSP27 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
2.5 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
HSPB1 / HSP27 ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
Viewing 1-25 of 36 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).