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HSP90 / Heat Shock Protein 90

Hsp90 (heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation. It also stabilizes a number of proteins required for tumor growth, which is why Hsp90 inhibitors are investigated as anti-cancer drugs. Heat shock proteins, as a class, are among the most highly expressed cellular proteins across all species. As their name implies, heat shock proteins protect cells when stressed by elevated temperatures. They account for 1–2% of total protein in unstressed cells. However, when cells are heated, the fraction of heat shock proteins increases to 4–6% of cellular proteins. Heat shock protein 90 (Hsp90) is one of the most common of the heat-related proteins. The "90" comes from the fact that it weighs roughly 90 kiloDaltons. A 90 kDa protein is considered fairly large for a non-fibrous protein. Hsp90 is found in bacteria and all branches of eukarya, but it is apparently absent in archaea. Whereas cytoplasmic Hsp90 is essential for viability under all conditions in eukaryotes, the bacterial homologue HtpG is dispensable under non-heat stress conditions.

HSP90 / Heat Shock Protein 90 Target Details

Target Name: HSP90 / Heat Shock Protein 90
Target Abbreviation: HSP90

Publications (2)

1
Effect of ethanol extracts of Hericium erinaceus mycelium on morphine-induced microglial migration. Chung-Hsin Yeh, Li-Wei Sun, Chang-Mei Lai, Tzu-Pei Yeh, Jong-Ni Lin, Shiow-Luan Tsay, Chin-Chu Chen, Wan-Ping Chen, Chien-Min Chen, Ru-Yin Tsai. Molecular medicine reports. 2019 December;20:5279-5285. [Full Text Article] [PubMed:31638202] Related Antibodies: LS-C380587.
2
Co-chaperones TIMP2 and AHA1 Competitively Regulate Extracellular HSP90:Client MMP2 Activity and Matrix Proteolysis. Alexander J Baker-Williams, Fiza Hashmi, Marek A Budzynski, Mark R Woodford, Stephanie Gleicher, Samu V Himanen, Alan M Makedon, Derek Friedman, Stephanie Cortes, Sara Namek, William G Stetler-Stevenson, Gennady Bratslavsky, Alaji Bah, Mehdi Mollapour, Lea Sistonen, Dimitra Bourboulia. Cell reports. 2019 Aug;28:1894-1906.e6. [Full Text Article] [PubMed:31412254] [PMC:PMC8276117]

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ELISA Kits (18)
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HSP90 / Heat Shock Protein 90 (18)
Human (7)
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Rat (3)
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Guinea pig (1)
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12 x 8-Well Microstrips (2)
96-Well Microplate (5)
96-Well Strip Plate (11)
No (17)
Yes (1)
Cell Culture Supernatants (2)
Cell Lysates (2)
Plasma (14)
Serum (14)
Tissue Homogenates (6)
HSP90 / Heat Shock Protein 90 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$626
HSP90 / Heat Shock Protein 90 ELISA Kit
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Sandwich
96-Well Microplate
Rat
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$626
HSP90 / Heat Shock Protein 90 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$1,041
HSP90 / Heat Shock Protein 90 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
HSP90 / Heat Shock Protein 90 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
HSP90 / Heat Shock Protein 90 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
HSP90 / Heat Shock Protein 90 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
HSP90 / Heat Shock Protein 90 ELISA Kit
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Sandwich
96-Well Microplate
Human
3.13 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$626
HSP90 / Heat Shock Protein 90 ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$627
HSP90 / Heat Shock Protein 90 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$627
HSP90 / Heat Shock Protein 90 ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$627
HSP90 / Heat Shock Protein 90 ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$627
HSP90 / Heat Shock Protein 90 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
HSP90 / Heat Shock Protein 90 ELISA Kit
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Sandwich
96-Well Microplate
Pig
4.688 - 300 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$627
HSP90 / Heat Shock Protein 90 ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Rat
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
HSP90 / Heat Shock Protein 90 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
HSP90 / Heat Shock Protein 90 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
HSP90 / Heat Shock Protein 90 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$826
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).