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HSD-1 / SPAG8

sperm associated antigen 8

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. This protein interacts with ACT (activator of CREM in testis) and may play a role in CREM (cAMP response element modulator)-ACT-mediated gene transcription during spermatogenesis. This protein may also play a role in spermatogenesis by regulating microtubule formation and cell division. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.

Gene Name: sperm associated antigen 8
Synonyms: SPAG8, Sperm membrane protein BS-84, Sperm-associated antigen 8, SMP-1, Sperm associated antigen 8, SMP1, SPAG3, BS-84, HSD-1, HSMP-1, Sperm membrane protein 1
Target Sequences: BC019247 AAH19247.1 Q99932

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Products
Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
HSD-1 / SPAG8 (4)
No (4)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (3)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (1)
HSD-1 / SPAG8 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
53.3 kDa
20 µg/$150
HSD-1 / SPAG8 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
53.3 kDa
100 µg/$494
HSD-1 / SPAG8 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
HSD-1 / SPAG8 Protein - 12.5% SDS-PAGE of human SPAG8 stained with Coomassie Blue
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Wheat Germ Extract
GST
80.85 kDa
10 µg/$479; 25 µg/$670
Viewing 1-4 of 4 product results


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Products: Proteins


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).