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Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA-GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry.
Gene Name: | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 |
Synonyms: | HS3ST5, 3-OST-5, 3OST5, H3-OST-5, Heparan sulfate 3-OST-5, HS3OST5, NBLA04021 |
Target Sequences: | Q8IZT8 Q8IZT8 |
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