HRS / HGS

hepatocyte growth factor-regulated tyrosine kinase substrate

Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.

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ELISA Kits (4)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Sandwich (2)

Target

HRS / HGS (4)

Reactivity

Human (4)

Mouse (2)

Rat (2)

Format

96-Well Microplate (2)

96-Well Strip Plate (2)

Publications

No (4)

Sample Type

Adherent Cell Cultures (2)

Plasma (2)

Serum (2)

Tissue Homogenates (1)

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Human HRS / HGS (Sandwich ELISA) ELISA Kit - LS-F31922

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

23.438 - 1500 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human HRS / HGS (Sandwich ELISA) ELISA Kit - LS-F38121

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Mouse/Human/Rat HRS / HGS (Cell-Based ELISA) ELISA Kit - LS-F2048

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Mouse/Human/Rat Phospho-HRS / HGS (Tyr334) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1392

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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