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HRAS / H-Ras

Harvey rat sarcoma viral oncogene homolog

HRAS / H-Ras belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

Gene Name: Harvey rat sarcoma viral oncogene homolog
Family/Subfamily: Ras GTPase superfamily IPR001806 , RAS oncogene
Synonyms: HRAS, C-H-RAS, C-has/bas p21 protein, C-ras-Ki-2 activated oncogene, C-HA-RAS1, CTLO, H-ras, H-RASIDX, GTP- and GDP-binding peptide B, GTPase HRas, H-Ras-1, HAMSV, HRAS1, K-RAS, Ha-Ras, Ha-Ras1 proto-oncoprotein, Transforming protein p21, N-ras, p21ras, RASH1, C-BAS/HAS, C-ha-ras, p19 H-RasIDX protein
Target Sequences: NM_005343 NP_005334.1 P01112

Publications (3)

1
Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response. Swarbrick A, Roy E, Allen T, Bishop JM. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:5402-7. (WB) [PubMed:18378907] [PMC:PMC2291136]
2
DNA methylation-regulated QPCT promotes sunitinib resistance by increasing HRAS stability in renal cell carcinoma. Zhao T, Bao Y, Gan X, Wang J, Chen Q, Dai Z, Liu B, Wang A, Sun S, Yang F, Wang L. Theranostics. 2019 August;9:6175-6190. [Full Text Article] [PubMed:31534544] [PMC:PMC6735520] Related Antibodies: LS-C340614.
3
Single-cell in situ imaging of palmitoylation in fatty-acylated proteins. Xinxin Gao, Rami N Hannoush. Nature protocols. 2014 November;9:2607-23. [Full Text Article] [PubMed:25299157] Related Antibodies: LS-C165008.

☰ Filters
Products
Proteins (16)
Over-Expression Lysate (7)
Recombinant (9)
HRAS / H-Ras (16)
No (16)
6His, N-terminus (1)
GST (1)
GST, N-terminus (1)
His (3)
His-T7 (1)
Myc-DDK (Flag) (9)
Human (12)
Rat (1)
293T Cells (4)
Baculovirus (1)
E. coli (4)
HEK 293 Cells (5)
Wheat Germ Extract (2)
Purified (3)
Low endotoxin level (1)
HRAS / H-Ras Protein - 12.5% SDS-PAGE of human HRAS stained with Coomassie Blue
Select
Wheat Germ Extract
GST
46.42 kDa
10 µg/$479; 25 µg/$670
Select
293T Cells
Myc-DDK (Flag)
18.7 kDa
20 µg/$150
HRAS / H-Ras Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
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E. coli
6His, N-terminus
24 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
HRAS / H-Ras Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
21.1 kDa
100 µg/$494
HRAS / H-Ras Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
HRAS / H-Ras Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
18.7 kDa
100 µg/$494
HRAS / H-Ras Protein
Select
E. coli
His
25 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
HRAS / H-Ras Protein - Purified recombinant protein HRAS was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
21.1 kDa
20 µg/$1,107
HRAS / H-Ras Protein - Purified recombinant protein HRAS was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
21.1 kDa
20 µg/$1,107
HRAS / H-Ras Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
21.1 kDa
20 µg/$150
HRAS / H-Ras Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
21.1 kDa
20 µg/$150
HRAS / H-Ras Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
18.7 kDa
20 µg/$150
HRAS / H-Ras Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
21.1 kDa
100 µg/$494
Select
Baculovirus
His
Less than 1.0 EU/µg protein (determined by LAL method).
22.4 kDa
100 µg/$793; 1 mg/$4,191
HRAS / H-Ras Protein
Select
E. coli
His
100 µg/$342; 500 µg/$641; 20 µg/$254
HRAS / H-Ras Protein - Recombinant V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog By SDS-PAGE
Select
E. coli
His-T7
14.8 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
Viewing 1-16 of 16 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).