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Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.
Gene Name: | hematopoietic prostaglandin D synthase |
Synonyms: | HPGDS, Glutathione S-transferase, GST class-sigma, GSTS1-1, H-PGDS, PGD2, PGDS, GSTS, Prostaglandin-H2 D-isomerase, PTGDS2 |
Target Sequences: | NM_014485 NP_055300.1 O60760 |
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