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HOXB6 is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer.
Gene Name: | homeobox B6 |
Synonyms: | HOXB6, Hox-2.2, HOX2B, Homeo box B6, Homeobox protein Hox-2.2, HU-2, Homeobox protein Hox-2B, Homeobox protein Hox-B6, Hox-b6, Homeo box 2B, Homeobox B6, Homeobox protein Hu-2, HOX2 |
Target Sequences: | NM_018952 NP_061825.2 P17509 |
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