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HOXA7
homeobox A7
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.
| Gene Name: | homeobox A7 |
| Synonyms: | HOXA7, Homeotic protein hox-a7, Homeo box A7, Homeobox A7, Homeobox protein Hox 1.1, Homeobox protein Hox-1A, HOX1, ANTP, Homeobox protein Hox-A7, HOX1.1, HOX1A |
| Target Sequences: | AF026397 AAB94604.1 P31268 |
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