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Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor.
Gene Name: | HOP homeobox |
Synonyms: | HOPX, CAMEO, HOD, Homeodomain-only protein, HOP, HOP homeobox, LAGY, NECC1, Odd homeobox protein 1, OB1, TOTO, Odd homeobox 1 protein, SMAP31 |
Target Sequences: | NM_032495 BAB40926.1 Q9BPY8 |
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