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HMOX1 / HO-1

heme oxygenase (decycling) 1

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.

Gene Name: heme oxygenase (decycling) 1
Synonyms: HMOX1, BK286B10, HO-1, HSP32, Heat shock protein, 32-kD, Heme oxygenase (decycling) 1, Heme oxygenase 1, HO1
Target Sequences: NM_002133 NP_002124.1 P09601

Publications (3)

1
Resuscitation with PEGylated carboxyhemoglobin preserves renal cortical oxygenation and improves skeletal muscle microcirculatory flow during endotoxemia. Philippe Guerci, Bülent Ergin, Asli Kandil, Yasin Ince, Paul Heeman, Matthias Peter Hilty, Jan Bakker, Can Ince. American journal of physiology. Renal physiology. 2020 May;318:F1271-F1283. [Full Text Article] [PubMed:32281418]
2
Effect of Polyethylene-glycolated Carboxyhemoglobin on Renal Microcirculation in a Rat Model of Hemorrhagic Shock. Philippe Guerci, Bulent Ergin, Aysegul Kapucu, Matthias P Hilty, Ronald Jubin, Jan Bakker, Can Ince. Anesthesiology. 2019 November;131:1110-1124. [Full Text Article] [PubMed:31490291]
3
Elevated Heme Oxygenase-1 Correlates With Increased Brain Iron Deposition Measured by Quantitative Susceptibility Mapping and Decreased Hemoglobin in Patients With Parkinson's Disease. Jinghui Xu , Chi Xiao, Weizheng Song, Xiangqin Cui, Mengqiu Pan, Qun Wang, Yanqiu Feng, Yunqi Xu. Frontiers in aging neuroscience. 2021 Mar;13:656626. [Full Text Article] [PubMed:33815094] [PMC:PMC8012799]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).