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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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HMG-CoA Reductase / HMGCR

3-hydroxy-3-methylglutaryl-CoA reductase

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Synonyms: HMGCR, HMG-CoA reductase, LDLCQ3
Target Sequences: NM_000859 NP_000850.1 P04035

Filtered by: None
Target
HMG-CoA Reductase / HMGCR (34)
Reactivity
Human (24)
Mouse (11)
Rat (21)
Dog (4)
Monkey (1)
Pig (4)
Yeast (4)
Application
IHC (20)
IHC-P (2)
WB (29)
ELISA (7)
ICC (3)
IF (3)
IP (1)
Peptide-ELISA (1)
Host
rabbit (33)
goat (1)
Isotype
IgG (12)
Clonality
polyclonal pc (34)
Format
APC (1)
APC Conjugated (1)
Biotin Conjugated (5)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (5)
HRP Conjugated (4)
PE Conjugated (1)
Unconjugated (16)
Epitope
aa638-887 (10)
C-Terminus (8)
aa295-308 (1)
aa571-855 (1)
Publications
No (34)
Showing 1-25 of 34 results

HMG-CoA Reductase / HMGCR Antibody (C-Terminus) IHC-plus™ LS-B14015
Rabbit Polyclonal to Human HMG-CoA Reductase / HMGCR
Mouse, Dog, Rat, Pig, Human, Yeast
IHC IHC-P WB
Unconjugated
100µl  $485.00
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

HMG-CoA Reductase / HMGCR Antibody (C-Terminus, FITC) LS-C446439
Rabbit Polyclonal to Human HMG-CoA Reductase / HMGCR
Mouse, Dog, Rat, Pig, Human, Yeast
WB
FITC Conjugated
100µl 1mg/ml  $385.00
Western blot of HMGCR Antibody with human Fetal Lung lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

HMG-CoA Reductase / HMGCR Antibody LS-C482295
Rabbit Polyclonal to Human HMG-CoA Reductase / HMGCR
Mouse, Rat, Human
ICC IF IHC-P WB
Unconjugated
50µl 1mg/ml  $255.00; 100µl 1mg/ml  $295.00; 200µl 1mg/ml  $375.00
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)

HMG-CoA Reductase / HMGCR Antibody LS-C331599
Rabbit Polyclonal (IgG) to Human HMG-CoA Reductase / HMGCR
Mouse, Rat, Human
IF IHC WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunohistochemistry of paraffin-embedded human kidney using IL23R antibody at dilution of 1:200 (x400 lens)
Immunofluorescence analysis of A549 cells.

HMG-CoA Reductase / HMGCR Antibody LS-C147064
Rabbit Polyclonal to Human HMG-CoA Reductase / HMGCR
Mouse, Rat, Human
WB
Unconjugated
30µg  $245.00; 100µg  $445.00

HMG-CoA Reductase / HMGCR Antibody LS-C748368
Rabbit Polyclonal (IgG) to Human HMG-CoA Reductase / HMGCR
Rat, Human
IF IHC WB
Unconjugated
50µl  $235.00; 100µl  $295.00; 200µl  $385.00
Immunohistochemistry of paraffin-embedded rat heart using HMGCR Antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human breast cancer using HMGCR Antibody at dilution of 1:100 (40x lens).

HMG-CoA Reductase / HMGCR Antibody LS-C285529
Rabbit Polyclonal (IgG) to Human HMG-CoA Reductase / HMGCR
Human
ELISA IHC WB
Unconjugated
50µg  $285.00; 100µg  $385.00

HMG-CoA Reductase / HMGCR Antibody (HRP) LS-C318764
Rabbit Polyclonal (IgG) to Human HMG-CoA Reductase / HMGCR
Human
ELISA IHC WB
HRP Conjugated
50µg  $285.00; 100µg  $385.00

HMG-CoA Reductase / HMGCR Antibody (Biotin) LS-C317112
Rabbit Polyclonal (IgG) to Human HMG-CoA Reductase / HMGCR
Human
ELISA IHC WB
Biotin Conjugated
50µg  $285.00; 100µg  $385.00

HMG-CoA Reductase / HMGCR Antibody (FITC) LS-C318761
Rabbit Polyclonal (IgG) to Human HMG-CoA Reductase / HMGCR
Human
ELISA IHC WB
FITC Conjugated
50µg  $285.00; 100µg  $385.00

HMG-CoA Reductase / HMGCR Antibody LS-C749723
Rabbit Polyclonal (IgG) to Human HMG-CoA Reductase / HMGCR
Mouse, Human
IHC WB
Unconjugated
50µl  $275.00; 100µl  $355.00; 200µl  $455.00
Immunohistochemistry of paraffin-embedded human colon carcinoma using HMGCR antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human lung cancer using HMGCR antibody at dilution of 1:100 (40x lens).

HMG-CoA Reductase / HMGCR Antibody LS-C666166
Rabbit Polyclonal (IgG) to Human HMG-CoA Reductase / HMGCR
Human
ELISA IHC
Unconjugated
100µg  $335.00

HMG-CoA Reductase / HMGCR Antibody LS-C405043
Rabbit Polyclonal (IgG) to Human HMG-CoA Reductase / HMGCR
Mouse, Rat, Human
ELISA IHC
Unconjugated
20µl 0.2mg/ml  $205.00; 60µl 0.2mg/ml  $235.00; 120µl 0.2mg/ml  $295.00; 200µl 0.2mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human liver cancer using HMGCR Polyclonal Antibody at dilution of 1:20.
Immunohistochemistry of paraffin-embedded Human liver cancer using HMGCR Polyclonal Antibody at dilution of 1:20.

HMG-CoA Reductase / HMGCR Antibody LS-C401740
Rabbit Polyclonal (IgG) to Human HMG-CoA Reductase / HMGCR
Mouse, Rat, Human
ELISA IHC
Unconjugated
20µl 0.2mg/ml  $205.00; 60µl 0.2mg/ml  $235.00; 120µl 0.2mg/ml  $295.00; 200µl 0.2mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human colon cancer using HMGCR Polyclonal Antibody at dilution of 1:20.
Immunohistochemistry of paraffin-embedded Human colon cancer using HMGCR Polyclonal Antibody at dilution of 1:20.

HMG-CoA Reductase / HMGCR Antibody LS-C192794
Rabbit Polyclonal to Human HMG-CoA Reductase / HMGCR
Mouse, Rat, Human
IHC WB
Unconjugated
100µl  $385.00
Western blot of extracts of various cell lines, using HMGCR antibody.

HMG-CoA Reductase / HMGCR Antibody (aa638-887) LS-C373178
Rabbit Polyclonal to Rat HMG-CoA Reductase / HMGCR
Rat
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $265.00; 200µl 0.5mg/ml  $315.00; 1ml 0.5mg/ml  $575.00; 10ml 0.5mg/ml  $2,280.00
Immunohistochemistry - Paraffin Image
Western blot of HMG-CoA Reductase / HMGCR antibody.

HMG-CoA Reductase / HMGCR Antibody (aa638-887, HRP) LS-C712670
Rabbit Polyclonal to Rat HMG-CoA Reductase / HMGCR
Rat
IHC WB
HRP Conjugated
100µl 0.5mg/ml  $295.00; 200µl 0.5mg/ml  $355.00; 1ml 0.5mg/ml  $740.00; 10ml 0.5mg/ml  $2,955.00
Immunohistochemistry - Paraffin Image
Western blot of HMG-CoA Reductase / HMGCR antibody.

HMG-CoA Reductase / HMGCR Antibody (aa638-887, Biotin) LS-C423271
Rabbit Polyclonal to Rat HMG-CoA Reductase / HMGCR
Rat
ICC WB
Biotin Conjugated
100µl 0.5mg/ml  $385.00

HMG-CoA Reductase / HMGCR Antibody (aa638-887, Biotin) LS-C688028
Rabbit Polyclonal to Rat HMG-CoA Reductase / HMGCR
Rat
IHC WB
Biotin Conjugated
100µl 0.5mg/ml  $275.00; 200µl 0.5mg/ml  $325.00; 1ml 0.5mg/ml  $620.00; 10ml 0.5mg/ml  $2,505.00
Immunohistochemistry - Paraffin Image
Western blot of HMG-CoA Reductase / HMGCR antibody.

HMG-CoA Reductase / HMGCR Antibody (aa638-887, FITC) LS-C423273
Rabbit Polyclonal to Rat HMG-CoA Reductase / HMGCR
Rat
ICC WB
FITC Conjugated
100µl 0.5mg/ml  $415.00

HMG-CoA Reductase / HMGCR Antibody (aa638-887, FITC) LS-C694940
Rabbit Polyclonal to Rat HMG-CoA Reductase / HMGCR
Rat
IHC WB
FITC Conjugated
100µl 0.5mg/ml  $285.00; 200µl 0.5mg/ml  $345.00; 1ml 0.5mg/ml  $680.00; 10ml 0.5mg/ml  $2,730.00
Immunohistochemistry - Paraffin Image
Western blot of HMG-CoA Reductase / HMGCR antibody.

HMG-CoA Reductase / HMGCR Antibody (aa638-887, Cy3) LS-C703644
Rabbit Polyclonal to Rat HMG-CoA Reductase / HMGCR
Rat
IHC WB
Cy3 Conjugated
100µl 0.5mg/ml  $375.00; 200µl 0.5mg/ml  $465.00; 1ml 0.5mg/ml  $1,140.00; 10ml 0.5mg/ml  $4,560.00
Immunohistochemistry - Paraffin Image
Western blot of HMG-CoA Reductase / HMGCR antibody.

HMG-CoA Reductase / HMGCR Antibody (aa638-887, APC, Cy7) LS-C735654
Rabbit Polyclonal to Rat HMG-CoA Reductase / HMGCR
Rat
IHC WB
APC, Cy7 Conjugated
100µl  $475.00; 200µl  $680.00; 1ml  $1,710.00; 10ml  $6,840.00
Immunohistochemistry - Paraffin Image
Western blot of HMG-CoA Reductase / HMGCR antibody.

HMG-CoA Reductase / HMGCR Antibody (aa638-887, APC) LS-C741132
Rabbit Polyclonal to Rat HMG-CoA Reductase / HMGCR
Rat
IHC WB
APC Conjugated
100µl  $315.00; 200µl  $385.00; 1ml  $860.00; 10ml  $1,770.00
Immunohistochemistry - Paraffin Image
Western blot of HMG-CoA Reductase / HMGCR antibody.

HMG-CoA Reductase / HMGCR Antibody (aa571-855) LS-C311702
Rabbit Polyclonal (IgG) to Human HMG-CoA Reductase / HMGCR
Human
WB
Unconjugated
100µl 1mg/ml  $355.00
Showing 1-25 of 34 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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