Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection (By similarity). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1.
|Gene Name:||histocompatibility (minor) 13|
|Family/Subfamily:||Protease , Aspartic A22B|
|Synonyms:||HM13, DJ324O17.1, HIMP1, IMP1, Intramembrane protease 1, H13, MSTP086, IMP-1, IMPAS, IMPAS-1, Presenilin-like protein 3, PSL3, Signal peptide peptidase, Signal peptide peptidase beta, SPP, PSENL3, SPPL1|
|Target Sequences:||NM_030789 NP_110416.1 Q8TCT9|
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