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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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HM13 / IMP-1 / SPP

histocompatibility (minor) 13

Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection (By similarity). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1.

Gene Name: histocompatibility (minor) 13
Family/Subfamily: Protease , Aspartic A22B
Synonyms: HM13, DJ324O17.1, HIMP1, IMP1, Intramembrane protease 1, H13, MSTP086, IMP-1, IMPAS, IMPAS-1, Presenilin-like protein 3, PSL3, Signal peptide peptidase, Signal peptide peptidase beta, SPP, PSENL3, SPPL1
Target Sequences: NM_030789 NP_110416.1 Q8TCT9

Filtered by: None
Target
HM13 / IMP-1 / SPP (18)
Reactivity
Human (18)
Mouse (8)
Rat (4)
Bovine (4)
Chicken (4)
Gibbon (3)
Pig (4)
Rabbit (4)
Xenopus (4)
Application
IHC (2)
IHC-P (1)
WB (18)
ELISA (12)
IP (1)
Host
rabbit (18)
Isotype
IgG (13)
Clonality
polyclonal pc (18)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (6)
Epitope
aa325-354 (8)
aa240-289 (4)
aa327-377 (1)
Publications
No (18)
Showing 1-18 of 18 results

IHC-plus™ HM13 / IMP-1 / SPP Antibody LS-B15247
Rabbit Polyclonal (IgG) to Human HM13 / IMP-1 / SPP
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg 1mg/ml  $425.00
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE), at a concentration of 10 ug/ml.
Immunofluorescent analysis of 293 cells using HM13 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

HM13 / IMP-1 / SPP Antibody (HRP) LS-C378936
Rabbit Polyclonal (IgG) to Human HM13 / IMP-1 / SPP
Mouse, Human
ELISA, WB
HRP Conjugated
50µg  $285.00; 100µg  $385.00

HM13 / IMP-1 / SPP Antibody (Biotin) LS-C378940
Rabbit Polyclonal (IgG) to Human HM13 / IMP-1 / SPP
Mouse, Human
ELISA, WB
Biotin Conjugated
50µg  $285.00; 100µg  $385.00

HM13 / IMP-1 / SPP Antibody (FITC) LS-C378938
Rabbit Polyclonal (IgG) to Human HM13 / IMP-1 / SPP
Mouse, Human
ELISA, WB
FITC Conjugated
50µg  $285.00; 100µg  $385.00

HM13 / IMP-1 / SPP Antibody (aa240-289) LS-C135236
Rabbit Polyclonal to Mouse HM13 / IMP-1 / SPP
Xenopus, Chicken, Bovine, Rabbit, Mouse, Rat, Pig, Human
WB
Unconjugated
100µl 0.5mg/ml  $365.00
HM13 antibody Western blot of Mouse Spleen lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

HM13 / IMP-1 / SPP Antibody (aa240-289, HRP) LS-C453117
Rabbit Polyclonal to Mouse HM13 / IMP-1 / SPP
Xenopus, Chicken, Bovine, Rabbit, Mouse, Rat, Pig, Gibbon, Human
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
HM13 antibody Western blot of Mouse Spleen lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

HM13 / IMP-1 / SPP Antibody (aa240-289, Biotin) LS-C453115
Rabbit Polyclonal to Mouse HM13 / IMP-1 / SPP
Xenopus, Chicken, Bovine, Rabbit, Mouse, Rat, Pig, Gibbon, Human
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
HM13 antibody Western blot of Mouse Spleen lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

HM13 / IMP-1 / SPP Antibody (aa240-289, FITC) LS-C453116
Rabbit Polyclonal to Mouse HM13 / IMP-1 / SPP
Xenopus, Chicken, Bovine, Rabbit, Mouse, Rat, Pig, Gibbon, Human
WB
FITC Conjugated
100µl 1mg/ml  $385.00
HM13 antibody Western blot of Mouse Spleen lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

HM13 / IMP-1 / SPP Antibody LS-C752021
Rabbit Polyclonal (IgG) to Human HM13 / IMP-1 / SPP
Human
ELISA, IHC, WB
Unconjugated
100µg  $355.00

HM13 / IMP-1 / SPP Antibody (aa325-354) LS-C321999
Rabbit Polyclonal (IgG) to Human HM13 / IMP-1 / SPP
Human
ELISA, WB
Unconjugated
200µl  $590.00

HM13 / IMP-1 / SPP Antibody (aa325-354, Biotin) LS-C236294
Rabbit Polyclonal (IgG) to Human HM13 / IMP-1 / SPP
Human
ELISA, WB
Biotin Conjugated
200µl  $740.00

HM13 / IMP-1 / SPP Antibody (aa325-354, FITC) LS-C236295
Rabbit Polyclonal (IgG) to Human HM13 / IMP-1 / SPP
Human
ELISA, WB
FITC Conjugated
200µl  $740.00

HM13 / IMP-1 / SPP Antibody (aa325-354, PE) LS-C246750
Rabbit Polyclonal (IgG) to Human HM13 / IMP-1 / SPP
Human
ELISA, WB
PE Conjugated
200µl  $740.00

HM13 / IMP-1 / SPP Antibody (aa325-354, Azide-free, HRP) LS-C249204
Rabbit Polyclonal (IgG) to Human HM13 / IMP-1 / SPP
Human
ELISA, WB
HRP Conjugated, Azide-free
200µl  $740.00

HM13 / IMP-1 / SPP Antibody (aa325-354, AP) LS-C236292
Rabbit Polyclonal (IgG) to Human HM13 / IMP-1 / SPP
Human
ELISA, WB
AP Conjugated
200µl  $740.00

HM13 / IMP-1 / SPP Antibody (aa325-354, APC) LS-C236293
Rabbit Polyclonal (IgG) to Human HM13 / IMP-1 / SPP
Human
ELISA, WB
APC Conjugated
200µl  $740.00

HM13 / IMP-1 / SPP Antibody (aa327-377) LS-C291042
Rabbit Polyclonal (IgG) to Human HM13 / IMP-1 / SPP
Human
IP, WB
Unconjugated
100µl 1mg/ml  $395.00
Detection of Human SPP by Western Blot. Samples: Whole cell lysate (50 ug) prepared using NETN buffer from HeLa, 293T, and Jurkat cells. Antibodies: Affinity purified rabbit anti-SPP antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

HM13 / IMP-1 / SPP Antibody (aa325-354) LS-C164926
Rabbit Polyclonal to Human HM13 / IMP-1 / SPP
Human
WB
Unconjugated
400µl  $325.00
HM13 Antibody western blot of HeLa cell line lysates (35 ug/lane). The HM13 antibody detected the HM13 protein (arrow).
Showing 1-18 of 18 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).