HLA-DQB1

major histocompatibility complex, class II, DQ beta 1

HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

HLA-DQB1 (5)

Publications

No (5)

Tag

6His, N-terminus (1)

GST (2)

Myc-DDK (Flag) (2)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human HLA-DQB1 Protein (Recombinant 6His, N-terminus) - LS-G137260

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

27.0 kDa

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human HLA-DQB1 Protein (Recombinant GST) - LS-G132108

Tag:

GST

Molecular Weight:

35.42kDa

Price:

10 µg/$479; 25 µg/$670

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HLA-DQB1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118172

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

29.7 kDa

Price:

100 µg/$494

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Human HLA-DQB1 Protein (Recombinant GST) (Full Length) - LS-G28842

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

56.3 kDa

Price:

10 µg/$479; 25 µg/$670

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Human HLA-DQB1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G93808

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

29.7 kDa

Price:

20 µg/$150

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