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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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HLA-DPB1

major histocompatibility complex, class II, DP beta 1

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

Gene Name: major histocompatibility complex, class II, DP beta 1
Synonyms: HLA-DPB1, Class II HLA beta chain, HLA-DP1B, MHC class II antigen DPbeta1, MHC class II antigen DPB1, MHC class II HLA-DRB1, MHC HLA DPB1, HLA-DPB, MHC class II HLA-DP-beta-1, DPB1, HLA DP14-beta chain, MHC class II HLA-DP-beta
Target Sequences: NM_002121 NP_002112.3 P04440

Filtered by: None
Target
HLA-DPB1 (32)
Reactivity
Human (32)
Mouse (7)
Rat (5)
Dog (4)
Gibbon (3)
Rabbit (4)
Application
IHC (25)
IHC-P (11)
WB (27)
Flo (4)
ELISA (14)
IF (4)
IP (1)
Host
rabbit (26)
mouse (6)
Isotype
IgG (19)
IgG2a,k (1)
IgG2b,k (4)
Clonality
monoclonal mc (5)
polyclonal pc (27)
Clone
6C6 (1)
BraFB6 (2)
SPM421 (2)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (3)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (20)
Epitope
aa77-105 (8)
aa98-147 (4)
Publications
No (32)
Showing 1-25 of 32 results

IHC-plus™ HLA-DPB1 Antibody (clone 6C6) LS-B12862
Mouse Monoclonal [clone 6C6] (IgG2a,k) to Human HLA-DPB1
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50µg  $495.00
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

HLA-DPB1 Antibody (clone BraFB6) LS-C390304
Mouse Monoclonal [clone BraFB6] (IgG2b,k) to Human HLA-DPB1
Human
Flo, IF, IHC, IHC-P
Unconjugated
20µg 0.2mg/ml  $295.00; 100µg 0.2mg/ml  $465.00

HLA-DPB1 Antibody (clone BraFB6, Azide-free) LS-C390306
Mouse Monoclonal [clone BraFB6] (IgG2b,k) to Human HLA-DPB1
Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free
100µg 1mg/ml  $465.00

HLA-DPB1 Antibody LS-C482279
Rabbit Polyclonal to Human HLA-DPB1
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50µl 1mg/ml  $255.00; 100µl 1mg/ml  $295.00; 200µl 1mg/ml  $375.00
Immunohistochemical analysis of HLA-DPB1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Western blot analysis of HLA-DPB1 expression in THP1 (A); mouse spleen (B); mouse liver (C) whole cell lysates.

HLA-DPB1 Antibody (clone SPM421) LS-C390301
Mouse Monoclonal [clone SPM421] (IgG2b,k) to Human HLA-DPB1
Human
Flo, IF, IHC, IHC-P
Unconjugated
20µg 0.2mg/ml  $295.00; 100µg 0.2mg/ml  $465.00

HLA-DPB1 Antibody (clone SPM421, Azide-free) LS-C390305
Mouse Monoclonal [clone SPM421] (IgG2b,k) to Human HLA-DPB1
Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free
100µg 1mg/ml  $465.00

IHC-plus™ HLA-DPB1 Antibody LS-B13002
Rabbit Polyclonal (IgG) to Human HLA-DPB1
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg  $425.00
Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot All lanes: HLA class II histocompatibility antigen, DP beta 1 chain antibody at 2µg/ml Lane 1: sw1990 whole cell lysate Lane 2: HGC-27 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 26 kDa Observed band size: 26 kDa

HLA-DPB1 Antibody (HRP) LS-C370795
Rabbit Polyclonal (IgG) to Human HLA-DPB1
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50µg  $285.00; 100µg  $385.00
Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Immunohistochemistry of paraffin-embedded human tonsil using CSB-PA14809A0Rb at dilution of 1:50. This image was taken for the unconjugated form of this product. Other forms have not been tested.

HLA-DPB1 Antibody (Biotin) LS-C370797
Rabbit Polyclonal (IgG) to Human HLA-DPB1
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50µg  $285.00; 100µg  $385.00
Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Immunohistochemistry of paraffin-embedded human tonsil using CSB-PA14809A0Rb at dilution of 1:50. This image was taken for the unconjugated form of this product. Other forms have not been tested.

HLA-DPB1 Antibody (FITC) LS-C370796
Rabbit Polyclonal (IgG) to Human HLA-DPB1
Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
50µg  $285.00; 100µg  $385.00
Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Immunohistochemistry of paraffin-embedded human tonsil using CSB-PA14809A0Rb at dilution of 1:50. This image was taken for the unconjugated form of this product. Other forms have not been tested.

HLA-DPB1 Antibody (aa77-105) LS-C321992
Rabbit Polyclonal (IgG) to Human HLA-DPB1
Human
ELISA, IHC, WB
Unconjugated
200µl  $590.00

HLA-DPB1 Antibody (aa77-105, Biotin) LS-C236284
Rabbit Polyclonal (IgG) to Human HLA-DPB1
Human
ELISA, IHC, WB
Biotin Conjugated
200µl  $740.00

HLA-DPB1 Antibody (aa77-105, FITC) LS-C236285
Rabbit Polyclonal (IgG) to Human HLA-DPB1
Human
ELISA, IHC, WB
FITC Conjugated
200µl  $740.00

HLA-DPB1 Antibody (aa77-105, AP) LS-C236281
Rabbit Polyclonal (IgG) to Human HLA-DPB1
Human
ELISA, IHC, WB
AP Conjugated
200µl  $740.00

HLA-DPB1 Antibody (aa77-105, APC) LS-C236282
Rabbit Polyclonal (IgG) to Human HLA-DPB1
Human
ELISA, IHC, WB
APC Conjugated
200µl  $740.00

HLA-DPB1 Antibody (aa77-105, PE) LS-C236286
Rabbit Polyclonal (IgG) to Human HLA-DPB1
Human
ELISA, IHC, WB
PE Conjugated
200µl  $740.00

HLA-DPB1 Antibody (aa77-105, Azide-free, HRP) LS-C249202
Rabbit Polyclonal (IgG) to Human HLA-DPB1
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200µl  $740.00

HLA-DPB1 Antibody LS-C331451
Rabbit Polyclonal (IgG) to Human HLA-DPB1
Mouse, Human
IHC, WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunohistochemistry of paraffin-embedded human lymphonodus using HLA-DPB1 antibodyat dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human stomach using HLA-DPB1 antibodyat dilution of 1:100 (40x lens).

HLA-DPB1 Antibody LS-C806168
Rabbit Polyclonal (IgG) to Human HLA-DPB1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Western blot Image

HLA-DPB1 Antibody (aa77-105) LS-C164914
Rabbit Polyclonal to Human HLA-DPB1
Human
IHC, IHC-P, WB
Unconjugated
400µl  $325.00
HLA-DPB1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human tonsil tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Western blot of HLA-DPB1 (arrow) using rabbit polyclonal HLA-DPB1 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the HLA-DPB1 gene.

HLA-DPB1 Antibody LS-C754426
Rabbit Polyclonal (IgG) to Human HLA-DPB1
Human
ELISA, IHC
Unconjugated
100µg  $375.00

HLA-DPB1 Antibody LS-C341120
Rabbit Polyclonal to Human HLA-DPB1
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl 1mg/ml  $385.00

HLA-DPB1 Antibody LS-C767223
Rabbit Polyclonal (IgG) to Human HLA-DPB1
Mouse, Human
IHC, WB
Unconjugated
60µl 1mg/ml  $235.00; 120µl 1mg/ml  $295.00; 200µl 1mg/ml  $395.00

HLA-DPB1 Antibody LS-C749010
Rabbit Polyclonal (IgG) to Human HLA-DPB1
Mouse, Rat, Human
IHC, WB
Unconjugated
50µl  $235.00; 100µl  $295.00; 200µl  $385.00
Western blot analysis of extracts of various cell lines, using HLA-DPB1 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 30s.

HLA-DPB1 Antibody LS-C748367
Rabbit Polyclonal (IgG) to Human HLA-DPB1
Mouse, Rat, Human
IHC, WB
Unconjugated
50µl  $235.00; 100µl  $295.00; 200µl  $385.00
Western blot analysis of extracts of various cell lines, using HLA-DPB1 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
Showing 1-25 of 32 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).