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HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008]
Gene Name: | major histocompatibility complex, class II, DO alpha |
Synonyms: | HLA-DOA, HLA-D0-alpha, HLA-DZA, Lymphocyte antigen, MHC class II antigen DOA, MHC DZ alpha, HLA-DNA, HLADZ, MHC DN-alpha |
Target Sequences: | NM_002119 NP_002110.1 P06340 |
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