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HIST3H3

histone cluster 3, H3

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.

Gene Name: histone cluster 3, H3
Synonyms: HIST3H3, Histone H3.1t, H3t, Histone 3, H3, Histone cluster 3, H3
Target Sequences: NM_003493 NP_003484.1 Q16695

Publications (1)

1
Dpp-expressing and non-expressing cells: two different populations of growing cells in Drosophila. Carolina Arias, Gimena Fussero, Marcelo Zacharonok, Ana Macías. PloS one. 2015 March;10:e0121457. [Full Text Article] [PubMed:25798905] [PMC:PMC4370563] Related Antibodies: LS-C745457.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).