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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.
Gene Name: | histone cluster 1, H2bb |
Synonyms: | HIST1H2BB, H2B.1, Histone H2B type 1-B, Histone H2B.f, Histone H2b, Histone H2B.1, Histone 1, H2bb, Histone cluster 1, H2bb |
Target Sequences: | NM_021062 NP_066406.1 P33778 |
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