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Unfortunately, the antibody (ID:191252) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



HIF2A / EPAS1

endothelial PAS domain protein 1

Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.

Gene Name: endothelial PAS domain protein 1
Synonyms: EPAS1, BHLHe73, ECYT4, HIF-1-alpha-like factor, HIF2-alpha, HIF2A, EPAS-1, HIF-2-alpha, HIF-1alpha-like factor, MOP2, Member of PAS protein 2, PASD2
Target Sequences: NM_001430 NP_001421.2 Q99814

Publications (259)

1
[Fibroxanthoma retroperitonei]. Biernat S. Wiadomoci lekarskie (Warsaw, Poland : 1960). 1976 29:845-8. (WB; Human) [PubMed:1274359]
2
Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. Wiesener MS, Turley H, Allen WE, Willam C, Eckardt KU, Talks KL, Wood SM, Gatter KC, Harris AL, Pugh CW, Ratcliffe PJ, Maxwell PH. Blood. 1998 92:2260-8. [PubMed:9746763]
3
EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. Conrad PW, Freeman TL, Beitner-Johnson D, Millhorn DE. The Journal of biological chemistry. 1999 274:33709-13. (WB; Mouse) [PubMed:10559262]
4
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Ohh M, Park CW, Ivan M, Hoffman MA, Kim TY, Huang LE, Pavletich N, Chau V, Kaelin WG. Nature cell biology. 2000 2:423-7. [PubMed:10878807]
5
Expression, ontogeny, and regulation of hypoxia-inducible transcription factors in the human placenta. Rajakumar A, Conrad KP. Biology of reproduction. 2000 63:559-69. [PubMed:10906065]
6
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL. The American journal of pathology. 2000 157:411-21. (IHC, WB, IHC-P; Human) [PubMed:10934146] [PMC:PMC1850121]
7
Role of exon 2-encoded beta -domain of the von Hippel-Lindau tumor suppressor protein. Bonicalzi ME, Groulx I, de Paulsen N, Lee S. The Journal of biological chemistry. 2001 276:1407-16. [PubMed:11024059]
8
Relationship of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression to vascular endothelial growth factor induction and hypoxia survival in human breast cancer cell lines. Blancher C, Moore JW, Talks KL, Houlbrook S, Harris AL. Cancer research. 2000 60:7106-13. (IHC, WB) [PubMed:11156418]
9
Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis. de Paulsen N, Brychzy A, Fournier MC, Klausner RD, Gnarra JR, Pause A, Lee S. Proceedings of the National Academy of Sciences of the United States of America. 2001 98:1387-92. (WB, Flo; Human) [PubMed:11171960] [PMC:PMC29266]
10
Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Haase VH, Glickman JN, Socolovsky M, Jaenisch R. Proceedings of the National Academy of Sciences of the United States of America. 2001 98:1583-8. [PubMed:11171994] [PMC:PMC29300]
11
Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy. Koukourakis MI, Giatromanolaki A, Skarlatos J, Corti L, Blandamura S, Piazza M, Gatter KC, Harris AL. Cancer research. 2001 61:1830-2. (IHC-P; Human) [PubMed:11280732]
12
Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. Alvarez-Tejado M, Naranjo-Suarez S, Jimnez C, Carrera AC, Landzuri MO, del Peso L. The Journal of biological chemistry. 2001 276:22368-74. (WB; Mouse) [PubMed:11294857]
13
A variant of nuclear localization signal of bipartite-type is required for the nuclear translocation of hypoxia inducible factors (1alpha, 2alpha and 3alpha). Luo JC, Shibuya M. Oncogene. 2001 20:1435-44. [PubMed:11313887]
14
Histologic atrial myolysis is associated with atrial fibrillation after cardiac operation. Ad N, Snir E, Vidne BA, Golomb E. The Annals of thoracic surgery. 2001 72:688-93. [PubMed:11565642]
15
Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer. Giatromanolaki A, Koukourakis MI, Sivridis E, Pastorek J, Wykoff CC, Gatter KC, Harris AL. Cancer research. 2001 61:7992-8. (IHC-P; Human) [PubMed:11691824]
16
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Makino Y, Cao R, Svensson K, Bertilsson G, Asman M, Tanaka H, Cao Y, Berkenstam A, Poellinger L. Nature. 2001 414:550-4. [PubMed:11734856]
17
Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect. Minchenko A, Leshchinsky I, Opentanova I, Sang N, Srinivas V, Armstead V, Caro J. The Journal of biological chemistry. 2002 277:6183-7. [PubMed:11744734]
18
Expression of HIF-1alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy. Burke B, Tang N, Corke KP, Tazzyman D, Ameri K, Wells M, Lewis CE. The Journal of pathology. 2002 196:204-12. [PubMed:11793372]
19
Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension. Alvarez-Tejado M, Alfranca A, Aragons J, Vara A, Landzuri MO, del Peso L. The Journal of biological chemistry. 2002 277:13508-17. (WB; Human) [PubMed:11815624]
20
Activation of vascular endothelial growth factor A transcription in tumorigenic glioblastoma cell lines by an enhancer with cell type-specific DNase I accessibility. Liang Y, Li XY, Rebar EJ, Li P, Zhou Y, Chen B, Wolffe AP, Case CC. The Journal of biological chemistry. 2002 277:20087-94. [PubMed:11912213]
21
Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients. Beasley NJ, Leek R, Alam M, Turley H, Cox GJ, Gatter K, Millard P, Fuggle S, Harris AL. Cancer research. 2002 62:2493-7. (IHC-P; Human) [PubMed:11980639]
22
Positive expression of HIF-2alpha/EPAS1 in invasive bladder cancer. Xia G, Kageyama Y, Hayashi T, Hyochi N, Kawakami S, Kihara K. Urology. 2002 59:774-8. [PubMed:11992927]
23
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin WG. Cancer cell. 2002 1:237-46. [PubMed:12086860]
24
The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma. Maranchie JK, Vasselli JR, Riss J, Bonifacino JS, Linehan WM, Klausner RD. Cancer cell. 2002 1:247-55. [PubMed:12086861]
25
Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance. Bernaudin M, Tang Y, Reilly M, Petit E, Sharp FR. The Journal of biological chemistry. 2002 277:39728-38. [PubMed:12145288]
26
Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. Chan DA, Sutphin PD, Denko NC, Giaccia AJ. The Journal of biological chemistry. 2002 277:40112-7. [PubMed:12186875]
27
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth. Mack FA, Rathmell WK, Arsham AM, Gnarra J, Keith B, Simon MC. Cancer cell. 2003 3:75-88. [PubMed:12559177]
28
Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha. Yuan Y, Hilliard G, Ferguson T, Millhorn DE. The Journal of biological chemistry. 2003 278:15911-6. [PubMed:12606543]
29
Induction of T-type calcium channel gene expression by chronic hypoxia. Del Toro R, Levitsky KL, Lpez-Barneo J, Chiara MD. The Journal of biological chemistry. 2003 278:22316-24. [PubMed:12679337]
30
HIF-2alpha regulates glyceraldehyde-3-phosphate dehydrogenase expression in endothelial cells. Graven KK, Bellur D, Klahn BD, Lowrey SL, Amberger E. Biochimica et biophysica acta. 2003 1626:8-Oct. [PubMed:12697324]
31
Overexpression of the EGFR/FKBP12/HIF-2alpha pathway identified in childhood astrocytomas by angiogenesis gene profiling. Khatua S, Peterson KM, Brown KM, Lawlor C, Santi MR, LaFleur B, Dressman D, Stephan DA, MacDonald TJ. Cancer research. 2003 63:1865-70. [PubMed:12702575]
32
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Mabjeesh NJ, Escuin D, LaVallee TM, Pribluda VS, Swartz GM, Johnson MS, Willard MT, Zhong H, Simons JW, Giannakakou P. Cancer cell. 2003 3:363-75. [PubMed:12726862]
33
Down-regulation of hypoxia-inducible factor-2 in PC12 cells by nerve growth factor stimulation. Naranjo-Surez S, Castellanos MC, Alvarez-Tejado M, Vara A, Landzuri MO, del Peso L. The Journal of biological chemistry. 2003 278:31895-901. [PubMed:12805361]
34
Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Park SK, Dadak AM, Haase VH, Fontana L, Giaccia AJ, Johnson RS. Molecular and cellular biology. 2003 23:4959-71. [PubMed:12832481] [PMC:PMC162224]
35
Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3'-kinase/protein kinase B in prostate cancer cells. Mabjeesh NJ, Willard MT, Frederickson CE, Zhong H, Simons JW. Clinical cancer research : an official journal of the American Association for Cancer Research. 2003 9:2416-25. [PubMed:12855613]
36
Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells. Palayoor ST, Tofilon PJ, Coleman CN. Clinical cancer research : an official journal of the American Association for Cancer Research. 2003 9:3150-7. [PubMed:12912967]
37
von Hippel-Lindau protein complex is regulated by cell density. Mohan S, Burk RD. Oncogene. 2003 22:5270-80. (WB) [PubMed:12917628]
38
Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Staller P, Sulitkova J, Lisztwan J, Moch H, Oakeley EJ, Krek W. Nature. 2003 425:307-11. [PubMed:13679920]
39
The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen. del Peso L, Castellanos MC, Temes E, Martin-Puig S, Cuevas Y, Olmos G, Landazuri MO. The Journal of biological chemistry. 2003 278:48690-5. [PubMed:14506252]
40
Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein. Corn PG, McDonald ER, Herman JG, El-Deiry WS. Nature genetics. 2003 35:229-37. [PubMed:14556007]
41
Specific oncolytic effect of a new hypoxia-inducible factor-dependent replicative adenovirus on von Hippel-Lindau-defective renal cell carcinomas. Cuevas Y, Hernndez-Alcoceba R, Aragones J, Naranjo-Surez S, Castellanos MC, Esteban MA, Martn-Puig S, Landazuri MO, del Peso L. Cancer research. 2003 63:6877-84. [PubMed:14583486]
42
Role of iron (II)-2-oxoglutarate-dependent dioxygenases in the generation of hypoxia-induced phosphatidic acid through HIF-1/2 and von Hippel-Lindau-independent mechanisms. Martn-Puig S, Temes E, Olmos G, Jones DR, Aragons J, Landzuri MO. The Journal of biological chemistry. 2004 279:9504-11. [PubMed:14681229]
43
Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha. Uchida T, Rossignol F, Matthay MA, Mounier R, Couette S, Clottes E, Clerici C. The Journal of biological chemistry. 2004 279:14871-8. [PubMed:14744852]
44
Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors. Zimmer M, Doucette D, Siddiqui N, Iliopoulos O. Molecular cancer research : MCR. 2004 2:89-95. (WB) [PubMed:14985465]
45
Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. Mizukami Y, Li J, Zhang X, Zimmer MA, Iliopoulos O, Chung DC. Cancer research. 2004 64:1765-72. [PubMed:14996738]
46
Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha. Welsh S, Williams R, Kirkpatrick L, Paine-Murrieta G, Powis G. Molecular cancer therapeutics. 2004 3:233-44. [PubMed:15026543]
47
The PAI-1 gene as a direct target of endothelial PAS domain protein-1 in adenocarcinoma A549 cells. Sato M, Tanaka T, Maemura K, Uchiyama T, Sato H, Maeno T, Suga T, Iso T, Ohyama Y, Arai M, Tamura J, Sakamoto H, Nagai R, Kurabayashi M. American journal of respiratory cell and molecular biology. 2004 31:209-15. [PubMed:15039136]
48
p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment. Pan Y, Oprysko PR, Asham AM, Koch CJ, Simon MC. Oncogene. 2004 23:4975-83. [PubMed:15107830]
49
Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia. Tissot van Patot MC, Bendrick-Peart J, Beckey VE, Serkova N, Zwerdlinger L. American journal of physiology. Lung cellular and molecular physiology. 2004 287:L525-32. [PubMed:15132953]
50
Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates. Koike T, Kimura N, Miyazaki K, Yabuta T, Kumamoto K, Takenoshita S, Chen J, Kobayashi M, Hosokawa M, Taniguchi A, Kojima T, Ishida N, Kawakita M, Yamamoto H, Takematsu H, Suzuki A, Kozutsumi Y, Kannagi R, Kanangi R. Proceedings of the National Academy of Sciences of the United States of America. 2004 101:8132-7. [PubMed:15141079] [PMC:PMC419569]
51
Oxygen-regulated gene expression in bovine blastocysts. Harvey AJ, Kind KL, Pantaleon M, Armstrong DT, Thompson JG. Biology of reproduction. 2004 71:1108-19. [PubMed:15163614]
52
HIF activation by pH-dependent nucleolar sequestration of VHL. Mekhail K, Gunaratnam L, Bonicalzi ME, Lee S. Nature cell biology. 2004 6:642-7. [PubMed:15181450]
53
Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma. Grabmaier K, A de Weijert MC, Verhaegh GW, Schalken JA, Oosterwijk E. Oncogene. 2004 23:5624-31. (Human) [PubMed:15184875]
54
Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1. Takeda N, Maemura K, Imai Y, Harada T, Kawanami D, Nojiri T, Manabe I, Nagai R. Circulation research. 2004 95:146-53. [PubMed:15192019]
55
Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Biju MP, Neumann AK, Bensinger SJ, Johnson RS, Turka LA, Haase VH. Molecular and cellular biology. 2004 24:9038-47. [PubMed:15456877] [PMC:PMC517905]
56
Divergent expression patterns for hypoxia-inducible factor-1beta and aryl hydrocarbon receptor nuclear transporter-2 in developing kidney. Freeburg PB, Abrahamson DR. Journal of the American Society of Nephrology : JASN. 2004 15:2569-78. [PubMed:15466261]
57
Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Tang N, Wang L, Esko J, Giordano FJ, Huang Y, Gerber HP, Ferrara N, Johnson RS. Cancer cell. 2004 6:485-95. [PubMed:15542432]
58
In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations. Rathmell WK, Hickey MM, Bezman NA, Chmielecki CA, Carraway NC, Simon MC. Cancer research. 2004 64:8595-603. [PubMed:15574766]
59
Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex. Miller F, Kentsis A, Osman R, Pan ZQ. The Journal of biological chemistry. 2005 280:7985-96. [PubMed:15611064]
60
Prognostic impact of hypoxia-inducible factors 1alpha and 2alpha in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression. Yoshimura H, Dhar DK, Kohno H, Kubota H, Fujii T, Ueda S, Kinugasa S, Tachibana M, Nagasue N. Clinical cancer research : an official journal of the American Association for Cancer Research. 2004 10:8554-60. [PubMed:15623639]
61
Activation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase. Temes E, Martn-Puig S, Acosta-Iborra B, Castellanos MC, Feijoo-Cuaresma M, Olmos G, Aragons J, Landazuri MO. The Journal of biological chemistry. 2005 280:24238-44. [PubMed:15849364]
62
Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer. Smith K, Gunaratnam L, Morley M, Franovic A, Mekhail K, Lee S. Cancer research. 2005 65:5221-30. [PubMed:15958567]
63
Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung. Asikainen TM, Schneider BK, Waleh NS, Clyman RI, Ho WB, Flippin LA, Gnzler V, White CW. Proceedings of the National Academy of Sciences of the United States of America. 2005 102:10212-7. (WB; Human) [PubMed:16009933] [PMC:PMC1177409]
64
Evaluating hypoxia-inducible factor-1alpha as a cancer therapeutic target via inducible RNA interference in vivo. Li L, Lin X, Staver M, Shoemaker A, Semizarov D, Fesik SW, Shen Y. Cancer research. 2005 65:7249-58. (IHC, WB) [PubMed:16103076]
65
Impact of HIF-1alpha and HIF-2alpha on proliferation and migration of human pulmonary artery fibroblasts in hypoxia. Eul B, Rose F, Krick S, Savai R, Goyal P, Klepetko W, Grimminger F, Weissmann N, Seeger W, Hnze J. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006 20:163-5. [PubMed:16263938]
66
Hypoxic induction of an HIF-1alpha-dependent bFGF autocrine loop drives angiogenesis in human endothelial cells. Calvani M, Rapisarda A, Uranchimeg B, Shoemaker RH, Melillo G. Blood. 2006 107:2705-12. [PubMed:16304044] [PMC:PMC1895390]
67
Hypoxia and hypoxia-inducible factor-1alpha promote growth factor-induced proliferation of human vascular smooth muscle cells. Schultz K, Fanburg BL, Beasley D. American journal of physiology. Heart and circulatory physiology. 2006 290:H2528-34. [PubMed:16399861]
68
Clusterin is a secreted marker for a hypoxia-inducible factor-independent function of the von Hippel-Lindau tumor suppressor protein. Nakamura E, Abreu-e-Lima P, Awakura Y, Inoue T, Kamoto T, Ogawa O, Kotani H, Manabe T, Zhang GJ, Kondo K, Nos V, Kaelin WG. The American journal of pathology. 2006 168:574-84. [PubMed:16436671] [PMC:PMC1606480]
69
Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis. Kurban G, Hudon V, Duplan E, Ohh M, Pause A. Cancer research. 2006 66:1313-9. [PubMed:16452184]
70
Calcium signaling stimulates translation of HIF-alpha during hypoxia. Hui AS, Bauer AL, Striet JB, Schnell PO, Czyzyk-Krzeska MF. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006 20:466-75. [PubMed:16507764]
71
Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Krishnamachary B, Zagzag D, Nagasawa H, Rainey K, Okuyama H, Baek JH, Semenza GL. Cancer research. 2006 66:2725-31. [PubMed:16510593]
72
Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc. Mizukami Y, Fujiki K, Duerr EM, Gala M, Jo WS, Zhang X, Chung DC. The Journal of biological chemistry. 2006 281:13957-63. [PubMed:16543245]
73
Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1. Okuyama H, Krishnamachary B, Zhou YF, Nagasawa H, Bosch-Marce M, Semenza GL. The Journal of biological chemistry. 2006 281:15554-63. [PubMed:16574650]
74
Dynamic HIF1A regulation during human placental development. Ietta F, Wu Y, Winter J, Xu J, Wang J, Post M, Caniggia I. Biology of reproduction. 2006 75:112-21. (WB; Human) [PubMed:16611863]
75
Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Hu CJ, Iyer S, Sataur A, Covello KL, Chodosh LA, Simon MC. Molecular and cellular biology. 2006 26:3514-26. [PubMed:16611993] [PMC:PMC1447431]
76
Brain-derived neurotrophic factor activation of TrkB induces vascular endothelial growth factor expression via hypoxia-inducible factor-1alpha in neuroblastoma cells. Nakamura K, Martin KC, Jackson JK, Beppu K, Woo CW, Thiele CJ. Cancer research. 2006 66:4249-55. [PubMed:16618748]
77
Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization. Zheng X, Ruas JL, Cao R, Salomons FA, Cao Y, Poellinger L, Pereira T. Molecular and cellular biology. 2006 26:4628-41. [PubMed:16738327] [PMC:PMC1489139]
78
Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment. Bracken CP, Fedele AO, Linke S, Balrak W, Lisy K, Whitelaw ML, Peet DJ. The Journal of biological chemistry. 2006 281:22575-85. (WB; Human) [PubMed:16760477]
79
Priming-dependent phosphorylation and regulation of the tumor suppressor pVHL by glycogen synthase kinase 3. Hergovich A, Lisztwan J, Thoma CR, Wirbelauer C, Barry RE, Krek W. Molecular and cellular biology. 2006 26:5784-96. (WB; Human) [PubMed:16847331] [PMC:PMC1592755]
80
Primary cilium formation requires von hippel-lindau gene function in renal-derived cells. Lutz MS, Burk RD. Cancer research. 2006 66:6903-7. [PubMed:16849532]
81
Multiple acquired renal carcinoma tumor capabilities abolished upon silencing of ADAM17. Franovic A, Robert I, Smith K, Kurban G, Pause A, Gunaratnam L, Lee S. Cancer research. 2006 66:8083-90. [PubMed:16912185]
82
Renal cancer cells lacking hypoxia inducible factor (HIF)-1alpha expression maintain vascular endothelial growth factor expression through HIF-2alpha. Shinojima T, Oya M, Takayanagi A, Mizuno R, Shimizu N, Murai M. Carcinogenesis. 2007 28:529-36. (WB) [PubMed:16920734]
83
Differentiation arrest by hypoxia. Lin Q, Lee YJ, Yun Z. The Journal of biological chemistry. 2006 281:30678-83. (WB; Mouse) [PubMed:16926163]
84
Latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factors. Carroll PA, Kenerson HL, Yeung RS, Lagunoff M. Journal of virology. 2006 80:10802-12. (IHC-P; Human) [PubMed:16956952] [PMC:PMC1641760]
85
Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2. Takeda K, Ho VC, Takeda H, Duan LJ, Nagy A, Fong GH. Molecular and cellular biology. 2006 26:8336-46. [PubMed:16966370] [PMC:PMC1636770]
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The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes. Chavez JC, Baranova O, Lin J, Pichiule P. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 26:9471-81. [PubMed:16971531]
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Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII. Koizume S, Jin MS, Miyagi E, Hirahara F, Nakamura Y, Piao JH, Asai A, Yoshida A, Tsuchiya E, Ruf W, Miyagi Y. Cancer research. 2006 66:9453-60. (ChrIP) [PubMed:17018600]
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VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail. Evans AJ, Russell RC, Roche O, Burry TN, Fish JE, Chow VW, Kim WY, Saravanan A, Maynard MA, Gervais ML, Sufan RI, Roberts AM, Wilson LA, Betten M, Vandewalle C, Berx G, Marsden PA, Irwin MS, Teh BT, Jewett MA, Ohh M. Molecular and cellular biology. 2007 27:157-69. [PubMed:17060462] [PMC:PMC1800649]
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NAD(P)H oxidases regulate HIF-2alpha protein expression. Block K, Gorin Y, Hoover P, Williams P, Chelmicki T, Clark RA, Yoneda T, Abboud HE. The Journal of biological chemistry. 2007 282:8019-26. [PubMed:17200123]
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The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo. Yan Q, Bartz S, Mao M, Li L, Kaelin WG. Molecular and cellular biology. 2007 27:2092-102. [PubMed:17220275] [PMC:PMC1820491]
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Acute postnatal ablation of Hif-2alpha results in anemia. Gruber M, Hu CJ, Johnson RS, Brown EJ, Keith B, Simon MC. Proceedings of the National Academy of Sciences of the United States of America. 2007 104:2301-6. [PubMed:17284606] [PMC:PMC1892942]
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Hypoxia-inducible factors HIF-1alpha and HIF-2alpha are decreased in an experimental model of severe respiratory distress syndrome in preterm lambs. Grover TR, Asikainen TM, Kinsella JP, Abman SH, White CW. American journal of physiology. Lung cellular and molecular physiology. 2007 292:L1345-51. [PubMed:17307811]
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Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. Bernhardt WM, Wiesener MS, Weidemann A, Schmitt R, Weichert W, Lechler P, Campean V, Ong AC, Willam C, Gretz N, Eckardt KU. The American journal of pathology. 2007 170:830-42. (IHC-P; Rat) [PubMed:17322369] [PMC:PMC1864863]
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Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. MacKenzie ED, Selak MA, Tennant DA, Payne LJ, Crosby S, Frederiksen CM, Watson DG, Gottlieb E. Molecular and cellular biology. 2007 27:3282-9. [PubMed:17325041] [PMC:PMC1899954]
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Regulation of gene expression in bovine blastocysts in response to oxygen and the iron chelator desferrioxamine. Harvey AJ, Kind KL, Thompson JG. Biology of reproduction. 2007 77:93-101. (ICC; Human) [PubMed:17329595]
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Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney. Kojima I, Tanaka T, Inagi R, Kato H, Yamashita T, Sakiyama A, Ohneda O, Takeda N, Sata M, Miyata T, Fujita T, Nangaku M. Journal of the American Society of Nephrology : JASN. 2007 18:1218-26. [PubMed:17344427]
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Identification of functional endothelial progenitor cells suitable for the treatment of ischemic tissue using human umbilical cord blood. Nagano M, Yamashita T, Hamada H, Ohneda K, Kimura K, Nakagawa T, Shibuya M, Yoshikawa H, Ohneda O. Blood. 2007 110:151-60. [PubMed:17379743]
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HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller KI, Dang CV, Semenza GL. Cancer cell. 2007 11:407-20. [PubMed:17482131]
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Targeting the loss of the von Hippel-Lindau tumor suppressor gene in renal cell carcinoma cells. Sutphin PD, Chan DA, Li JM, Turcotte S, Krieg AJ, Giaccia AJ. Cancer research. 2007 67:5896-905. [PubMed:17575159]
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HIF-2alpha downregulation in the absence of functional VHL is not sufficient for renal cell differentiation. Hughes MD, Kapllani E, Alexander AE, Burk RD, Schoenfeld AR. Cancer cell international. 2007 7:13. [PubMed:17598890] [PMC:PMC1919349]
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HIF-1alpha and HIF-2alpha play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscle. Milkiewicz M, Doyle JL, Fudalewski T, Ispanovic E, Aghasi M, Haas TL. The Journal of physiology. 2007 583:753-66. [PubMed:17627993] [PMC:PMC2277012]
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Involvement of chloride channels in TGF-beta1-induced apoptosis of human bronchial epithelial cells. Cheng G, Shao Z, Chaudhari B, Agrawal DK. American journal of physiology. Lung cellular and molecular physiology. 2007 293:L1339-47. [PubMed:17873007]
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Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins. Takeda K, Aguila HL, Parikh NS, Li X, Lamothe K, Duan LJ, Takeda H, Lee FS, Fong GH. Blood. 2008 111:3229-35. [PubMed:18056838] [PMC:PMC2265459]
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Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein. Zhou G, Dada LA, Chandel NS, Iwai K, Lecuona E, Ciechanover A, Sznajder JI. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2008 22:1335-42. [PubMed:18073334]
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Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Minamishima YA, Moslehi J, Bardeesy N, Cullen D, Bronson RT, Kaelin WG. Blood. 2008 111:3236-44. (WB; Mouse) [PubMed:18096761] [PMC:PMC2265460]
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Cyr61/CCN1 and CTGF/CCN2 mediate the proangiogenic activity of VHL-mutant renal carcinoma cells. Chintalapudi MR, Markiewicz M, Kose N, Dammai V, Champion KJ, Hoda RS, Trojanowska M, Hsu T. Carcinogenesis. 2008 29:696-703. [PubMed:18212329] [PMC:PMC2288647]
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Oxygenated perfluorochemicals improve cell survival during reoxygenation by pacifying mitochondrial activity. Arab A, Kuemmerer K, Wang J, Bode C, Hehrlein C. The Journal of pharmacology and experimental therapeutics. 2008 325:417-24. [PubMed:18305017]
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Expression of hypoxia-inducible factor-1alpha and its relationship to tumour angiogenesis and cell proliferation in cartilage tumours. Kubo T, Sugita T, Shimose S, Matsuo T, Arihiro K, Ochi M. The Journal of bone and joint surgery. British volume. 2008 90:364-70. (WB, IHC-P; Human) [PubMed:18310762]
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PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis. Ginouvs A, Ilc K, Macas N, Pouyssgur J, Berra E. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:4745-50. [PubMed:18347341] [PMC:PMC2290777]
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Induction of HIF-2alpha is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line. Brown ST, Nurse CA. American journal of physiology. Cell physiology. 2008 294:C1305-12. [PubMed:18353899]
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HIV-1 upregulates VEGF in podocytes. Korgaonkar SN, Feng X, Ross MD, Lu TC, D'Agati V, Iyengar R, Klotman PE, He JC. Journal of the American Society of Nephrology : JASN. 2008 19:877-83. [PubMed:18443354] [PMC:PMC2386717]
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The microenvironment for erythropoiesis is regulated by HIF-2alpha through VCAM-1 in endothelial cells. Yamashita T, Ohneda O, Sakiyama A, Iwata F, Ohneda K, Fujii-Kuriyama Y. Blood. 2008 112:1482-92. [PubMed:18451309]
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The biphasic role of the hypoxia-inducible factor prolyl-4-hydroxylase, PHD2, in modulating tumor-forming potential. Lee, Lynd JD, O'Reilly S, Kiupel M, McCormick JJ, LaPres JJ. Molecular cancer research : MCR. 2008 6:829-42. [PubMed:18505927]
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Hypoxia-inducible factor-2alpha regulates the expression of TRAIL receptor DR5 in renal cancer cells. Mahajan S, Dammai V, Hsu T, Kraft AS. Carcinogenesis. 2008 29:1734-41. [PubMed:18544564] [PMC:PMC2527645]
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Activation of the VEGFR1 chromatin domain: an angiogenic signal-ETS1/HIF-2alpha regulatory axis. Dutta D, Ray S, Vivian JL, Paul S. The Journal of biological chemistry. 2008 283:25404-13. [PubMed:18625704] [PMC:PMC2533069]
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Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1alpha and -2alpha. Puppo M, Battaglia F, Ottaviano C, Delfino S, Ribatti D, Varesio L, Bosco MC. Molecular cancer therapeutics. 2008 7:1974-84. [PubMed:18645007]
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Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance. Lu CW, Lin SC, Chen KF, Lai YY, Tsai SJ. The Journal of biological chemistry. 2008 283:28106-14. [PubMed:18718909] [PMC:PMC2661383]
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A Key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1 (CYR61) in Tumor cells. Meyuhas R, Pikarsky E, Tavor E, Klar A, Abramovitch R, Hochman J, Lago TG, Honigman A. Molecular cancer research : MCR. 2008 6:1397-409. (WB; Mouse) [PubMed:18819928]
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Placental HIFs as markers of cerebral hypoxic distress in fetal mice. Trollmann R, Strasser K, Keller S, Antoniou X, Grenacher B, Ogunshola OO, Dtsch J, Rascher W, Gassmann M. American journal of physiology. Regulatory, integrative and comparative physiology. 2008 295:R1973-81. (IHC, WB; Mouse) [PubMed:18832080]
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Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation. Koh MY, Darnay BG, Powis G. Molecular and cellular biology. 2008 28:7081-95. [PubMed:18838541] [PMC:PMC2593390]
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Hypoxia decreases insulin signaling pathways in adipocytes. Regazzetti C, Peraldi P, Grmeaux T, Najem-Lendom R, Ben-Sahra I, Cormont M, Bost F, Le Marchand-Brustel Y, Tanti JF, Giorgetti-Peraldi S. Diabetes. 2009 58:95-103. [PubMed:18984735] [PMC:PMC2606898]
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Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth. Zhang H, Qian DZ, Tan YS, Lee K, Gao P, Ren YR, Rey S, Hammers H, Chang D, Pili R, Dang CV, Liu JO, Semenza GL. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:19579-86. [PubMed:19020076] [PMC:PMC2604945]
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Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy. Sears JE, Hoppe G, Ebrahem Q, Anand-Apte B. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:19898-903. [PubMed:19057008] [PMC:PMC2604934]
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Key role for activin B in cellular transformation after loss of the von Hippel-Lindau tumor suppressor. Wacker I, Sachs M, Knaup K, Wiesener M, Weiske J, Huber O, Aketin Z, Behrens J. Molecular and cellular biology. 2009 29:1707-18. [PubMed:19158274] [PMC:PMC2655617]
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Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Lee K, Qian DZ, Rey S, Wei H, Liu JO, Semenza GL. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:2353-8. [PubMed:19168635] [PMC:PMC2650160]
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Red wine polyphenols prevent acceleration of neovascularization by angiotensin II in the ischemic rat hindlimb. Walter A, Etienne-Selloum N, Brasse D, Schleiffer R, Bekaert V, Vanhoutte PM, Beretz A, Schini-Kerth VB. The Journal of pharmacology and experimental therapeutics. 2009 329:699-707. [PubMed:19193929]
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Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neur. Lomb DJ, Desouza LA, Franklin JL, Freeman RS. Molecular pharmacology. 2009 75:1198-209. (WB; Mouse) [PubMed:19204094] [PMC:PMC2672811]
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Signaling by hypoxia-inducible factors is critical for ovulation in mice. Kim J, Bagchi IC, Bagchi MK. Endocrinology. 2009 150:3392-400. [PubMed:19325003] [PMC:PMC2703551]
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HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury. Schdel J, Klanke B, Weidemann A, Buchholz B, Bernhardt W, Bertog M, Amann K, Korbmacher C, Wiesener M, Warnecke C, Kurtz A, Eckardt KU, Willam C. The American journal of pathology. 2009 174:1663-74. (WB; Mouse) [PubMed:19349364] [PMC:PMC2671255]
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Loss of VHL and hypoxia provokes PAX2 up-regulation in clear cell renal cell carcinoma. Luu VD, Boysen G, Struckmann K, Casagrande S, von Teichman A, Wild PJ, Sulser T, Schraml P, Moch H. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 15:3297-304. [PubMed:19401348]
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Increased prolyl 4-hydroxylase expression and differential regulation of hypoxia-inducible factors in the aged rat brain. Ndubuizu OI, Chavez JC, LaManna JC. American journal of physiology. Regulatory, integrative and comparative physiology. 2009 297:R158-65. [PubMed:19420289] [PMC:PMC2711700]
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Targeting both HIF-1 and HIF-2 in human colon cancer cells improves tumor response to sunitinib treatment. Burkitt K, Chun SY, Dang DT, Dang LH. Molecular cancer therapeutics. 2009 8:1148-56. [PubMed:19435875]
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Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Fang HY, Hughes R, Murdoch C, Coffelt SB, Biswas SK, Harris AL, Johnson RS, Imityaz HZ, Simon MC, Fredlund E, Greten FR, Rius J, Lewis CE. Blood. 2009 114:844-59. [PubMed:19454749] [PMC:PMC2882173]
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Docosahexaenoic acid inhibits superoxide dismutase 1 gene transcription in human cancer cells: the involvement of peroxisome proliferator-activated receptor alpha and hypoxia-inducible factor-2alpha signaling. Tuller ER, Beavers CT, Lou JR, Ihnat MA, Benbrook DM, Ding WQ. Molecular pharmacology. 2009 76:588-95. [PubMed:19528198]
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Iron transporters are differentially regulated by dietary iron, and modifications are associated with changes in manganese metabolism in young pigs. Hansen SL, Trakooljul N, Liu HC, Moeser AJ, Spears JW. The Journal of nutrition. 2009 139:1474-9. [PubMed:19535423]
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Differences in regulation of tight junctions and cell morphology between VHL mutations from disease subtypes. Bangiyeva V, Rosenbloom A, Alexander AE, Isanova B, Popko T, Schoenfeld AR. BMC cancer. 2009 9:229. [PubMed:19602254] [PMC:PMC2722669]
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Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease. Lee DW, Rajagopalan S, Siddiq A, Gwiazda R, Yang L, Beal MF, Ratan RR, Andersen JK. The Journal of biological chemistry. 2009 284:29065-76. [PubMed:19679656] [PMC:PMC2781452]
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A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo. Minamishima YA, Moslehi J, Padera RF, Bronson RT, Liao R, Kaelin WG. Molecular and cellular biology. 2009 29:5729-41. (WB; Mouse) [PubMed:19720742] [PMC:PMC2772748]
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Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Lee K, Zhang H, Qian DZ, Rey S, Liu JO, Semenza GL. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:17910-5. (ChrIP; Human) [PubMed:19805192] [PMC:PMC2764905]
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Ligand migration through the internal hydrophobic cavities in human neuroglobin. Abbruzzetti S, Faggiano S, Bruno S, Spyrakis F, Mozzarelli A, Dewilde S, Moens L, Viappiani C. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:18984-9. [PubMed:19850865] [PMC:PMC2776452]
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Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Krieg AJ, Rankin EB, Chan D, Razorenova O, Fernandez S, Giaccia AJ. Molecular and cellular biology. 2010 30:344-53. [PubMed:19858293] [PMC:PMC2798291]
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HIF-1alpha and HIF-2alpha are differentially regulated in vivo in neuroblastoma: high HIF-1alpha correlates negatively to advanced clinical stage and tumor vascularization. Noguera R, Fredlund E, Piqueras M, Pietras A, Beckman S, Navarro S, Phlman S. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 15:7130-6. [PubMed:19903792]
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Hypoxia-regulated delta-like 1 homologue enhances cancer cell stemness and tumorigenicity. Kim Y, Lin Q, Zelterman D, Yun Z. Cancer research. 2009 69:9271-80. [PubMed:19934310] [PMC:PMC2828615]
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Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha. Luo W, Zhong J, Chang R, Hu H, Pandey A, Semenza GL. The Journal of biological chemistry. 2010 285:3651-63. [PubMed:19940151] [PMC:PMC2823506]
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Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia. Rey S, Lee K, Wang CJ, Gupta K, Chen S, McMillan A, Bhise N, Levchenko A, Semenza GL. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:20399-404. [PubMed:19948968] [PMC:PMC2787122]
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Human cancers converge at the HIF-2alpha oncogenic axis. Franovic A, Holterman CE, Payette J, Lee S. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:21306-11. [PubMed:19955413] [PMC:PMC2795516]
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Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells. Martin SK, Diamond P, Williams SA, To LB, Peet DJ, Fujii N, Gronthos S, Harris AL, Zannettino AC. Haematologica. 2010 95:776-84. [PubMed:20015878] [PMC:PMC2864384]
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RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha. van Hagen M, Overmeer RM, Abolvardi SS, Vertegaal AC. Nucleic acids research. 2010 38:1922-31. [PubMed:20026589] [PMC:PMC2847224]
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Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors. Henze AT, Riedel J, Diem T, Wenner J, Flamme I, Pouyseggur J, Plate KH, Acker T. Cancer research. 2010 70:357-66. [PubMed:20028863]
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Hypoxia stimulates CXCR4 signalling in ileal carcinoids. Arvidsson Y, Bergstrm A, Arvidsson L, Kristiansson E, Ahlman H, Nilsson O. Endocrine-related cancer. 2010 17:303-16. (IHC; Human) [PubMed:20071457]
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Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms. Copple BL. Liver international : official journal of the International Association for the Study of the Liver. 2010 30:669-82. (WB; Mouse) [PubMed:20158611] [PMC:PMC3111074]
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Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia. Wu DC, Paulson RF. PloS one. 2010 5:e11303. (ChrIP; Mouse) [PubMed:20585586] [PMC:PMC2892039]
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Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1. Gimm T, Wiese M, Teschemacher B, Deggerich A, Schdel J, Knaup KX, Hackenbeck T, Hellerbrand C, Amann K, Wiesener MS, Hning S, Eckardt KU, Warnecke C. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2010 24:4443-58. (WB, ChrIP; Human) [PubMed:20624928]
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Cross-species comparison of genomewide gene expression profiles reveals induction of hypoxia-inducible factor-responsive genes in iron-deprived intestinal epithelial cells. Hu Z, Gulec S, Collins JF. American journal of physiology. Cell physiology. 2010 299:C930-8. [PubMed:20702690] [PMC:PMC2980301]
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Retina-specific activation of a sustained hypoxia-like response leads to severe retinal degeneration and loss of vision. Lange C, Caprara C, Tanimoto N, Beck S, Huber G, Samardzija M, Seeliger M, Grimm C. Neurobiology of disease. 2011 41:119-30. [PubMed:20817091]
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EMMPRIN promotes melanoma cells malignant properties through a HIF-2alpha mediated up-regulation of VEGF-receptor-2. Bougatef F, Menashi S, Khayati F, Nami B, Porcher R, Podgorniak MP, Millot G, Janin A, Calvo F, Lebb C, Mourah S. PloS one. 2010 5:e12265. (ICC, IHC, WB; Human) [PubMed:20824203] [PMC:PMC2930842]
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Hypoxia-inducible factor-1 regulates the expression of genes in hypoxic hepatic stellate cells important for collagen deposition and angiogenesis. Copple BL, Bai S, Burgoon LD, Moon JO. Liver international : official journal of the International Association for the Study of the Liver. 2011 31:230-44. [PubMed:20880076] [PMC:PMC3099214]
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The VHL-dependent regulation of microRNAs in renal cancer. Neal CS, Michael MZ, Rawlings LH, Van der Hoek MB, Gleadle JM. BMC medicine. 2010 8:64. [PubMed:20964835] [PMC:PMC2978113]
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Oxygen regulation of the epithelial Na channel in the collecting duct. Husted RF, Lu H, Sigmund RD, Stokes JB. American journal of physiology. Renal physiology. 2011 300:F412-24. [PubMed:21123494] [PMC:PMC3044001]
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Captopril modulates hypoxia-inducible factors and erythropoietin responses in a murine model of total body irradiation. Barshishat-Kupper M, Mungunsukh O, Tipton AJ, McCart EA, Panganiban RA, Davis TA, Landauer MR, Day RM. Experimental hematology. 2011 39:293-304. (WB; Mouse) [PubMed:21146580]
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A novel specific application of pyruvate protects the mouse retina against white light damage: differential stabilization of HIF-1 and HIF-2. Ren H, Liu NY, Song XF, Ma YS, Zhai XY. Investigative ophthalmology & visual science. 2011 52:3112-8. (WB; Mouse) [PubMed:21228376]
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VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration. Razorenova OV, Finger EC, Colavitti R, Chernikova SB, Boiko AD, Chan CK, Krieg A, Bedogni B, LaGory E, Weissman IL, Broome-Powell M, Giaccia AJ. Proceedings of the National Academy of Sciences of the United States of America. 2011 108:1931-6. (WB; Human) [PubMed:21233420] [PMC:PMC3033256]
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GSK-3: a signaling pathway node modulating neural stem cell and endothelial cell interactions. Li Q, Michaud M, Canosa S, Kuo A, Madri JA. Angiogenesis. 2011 14:173-85. (WB; Mouse) [PubMed:21253820]
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Hypoxia-inducible factor 2 (HIF-2) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension. Peng YJ, Nanduri J, Khan SA, Yuan G, Wang N, Kinsman B, Vaddi DR, Kumar GK, Garcia JA, Semenza GL, Prabhakar NR. Proceedings of the National Academy of Sciences of the United States of America. 2011 108:3065-70. [PubMed:21288809] [PMC:PMC3041114]
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NCX1 is a novel target gene for hypoxia-inducible factor-1 in ischemic brain preconditioning. Valsecchi V, Pignataro G, Del Prete A, Sirabella R, Matrone C, Boscia F, Scorziello A, Sisalli MJ, Esposito E, Zambrano N, Di Renzo G, Annunziato L. Stroke; a journal of cerebral circulation. 2011 42:754-63. (WB, ChrIP; Human) [PubMed:21293012]
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Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells. Place TL, Fitzgerald MP, Venkataraman S, Vorrink SU, Case AJ, Teoh ML, Domann FE. PloS one. 2011 6:e14617. (WB; Human) [PubMed:21297970] [PMC:PMC3030558]
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Association of elevated HIF-2 levels with low Beclin 1 expression and poor prognosis in patients with chondrosarcoma. Chen C, Ma Q, Ma X, Liu Z, Liu X. Annals of surgical oncology. 2011 18:2364-72. [PubMed:21327823]
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Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells. Higashimura Y, Nakajima Y, Yamaji R, Harada N, Shibasaki F, Nakano Y, Inui H. Archives of biochemistry and biophysics. 2011 509:8-Jan. (WB, ChrIP; Human) [PubMed:21338575]
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Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner. Chen R, Dioum EM, Hogg RT, Gerard RD, Garcia JA. The Journal of biological chemistry. 2011 286:13869-78. (WB, ChrIP; Human) [PubMed:21345792] [PMC:PMC3077588]
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Transcriptional regulation of the Menkes copper ATPase (Atp7a) gene by hypoxia-inducible factor (HIF2{alpha}) in intestinal epithelial cells. Xie L, Collins JF. American journal of physiology. Cell physiology. 2011 300:C1298-305. [PubMed:21346155] [PMC:PMC3118616]
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Hypoxia-inducible factor-2 mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice. Taylor M, Qu A, Anderson ER, Matsubara T, Martin A, Gonzalez FJ, Shah YM. Gastroenterology. 2011 140:2044-55. (WB, ChrIP; Mouse) [PubMed:21419768] [PMC:PMC3109109]
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Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Koivunen P, Lee S, Duncan CG, Lopez G, Lu G, Ramkissoon S, Losman JA, Joensuu P, Bergmann U, Gross S, Travins J, Weiss S, Looper R, Ligon KL, Verhaak RG, Yan H, Kaelin WG. Nature. 2012 483:484-8. [PubMed:22343896]
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Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism. Bardella C, Olivero M, Lorenzato A, Geuna M, Adam J, O'Flaherty L, Rustin P, Tomlinson I, Pollard PJ, Di Renzo MF. Molecular and cellular biology. 2012 32:3081-94. (WB; Human) [PubMed:22645311] [PMC:PMC3434507]
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Basal expression of copper transporter 1 in intestinal epithelial cells is regulated by hypoxia-inducible factor 2. Pourvali K, Matak P, Latunde-Dada GO, Solomou S, Mastrogiannaki M, Peyssonnaux C, Sharp PA. FEBS letters. 2012 586:2423-7. (WB; Human) [PubMed:22684009]
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AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma. Park SJ, Lee KS, Kim SR, Chae HJ, Yoo WH, Kim DI, Jeon MS, Lee YC. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2012 61:1069-83. (WB; Mouse) [PubMed:22692279]
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Identification and functional characterization of pVHL-dependent cell surface proteins in renal cell carcinoma. Boysen G, Bausch-Fluck D, Thoma CR, Nowicka AM, Stiehl DP, Cima I, Luu VD, von Teichman A, Hermanns T, Sulser T, Ingold-Heppner B, Fankhauser N, Wenger RH, Krek W, Schraml P, Wollscheid B, Moch H. Neoplasia (New York, N.Y.). 2012 14:535-46. (WB, ChrIP; Human) [PubMed:22806541] [PMC:PMC3394196]
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Hypoxic priming of mESCs accelerates vascular-lineage differentiation through HIF1-mediated inverse regulation of Oct4 and VEGF. Lee SW, Jeong HK, Lee JY, Yang J, Lee EJ, Kim SY, Youn SW, Lee J, Kim WJ, Kim KW, Lim JM, Park JW, Park YB, Kim HS. EMBO molecular medicine. 2012 4:924-38. (WB; Mouse) [PubMed:22821840] [PMC:PMC3491825]
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Hypoxia-inducible factor-1 (HIF1) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release. Hatano N, Itoh Y, Suzuki H, Muraki Y, Hayashi H, Onozaki K, Wood IC, Beech DJ, Muraki K. The Journal of biological chemistry. 2012 287:31962-72. (WB, ChrIP; Human) [PubMed:22843691] [PMC:PMC3442528]
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Downregulation of miR-205 modulates cell susceptibility to oxidative and endoplasmic reticulum stresses in renal tubular cells. Muratsu-Ikeda S, Nangaku M, Ikeda Y, Tanaka T, Wada T, Inagi R. PloS one. 2012 7:e41462. (WB; Human) [PubMed:22859986] [PMC:PMC3408438]
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Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1 and HIF2 in tumor-associated fibroblasts and human breast cancer cells. Chiavarina B, Martinez-Outschoorn UE, Whitaker-Menezes D, Howell A, Tanowitz HB, Pestell RG, Sotgia F, Lisanti MP. Cell cycle (Georgetown, Tex.). 2012 11:3280-9. (ICC, WB; Human) [PubMed:22894905] [PMC:PMC3466527]
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CD24 is an effector of HIF-1-driven primary tumor growth and metastasis. Thomas S, Harding MA, Smith SC, Overdevest JB, Nitz MD, Frierson HF, Tomlins SA, Kristiansen G, Theodorescu D. Cancer research. 2012 72:5600-12. (WB; Human) [PubMed:22926560] [PMC:PMC3488144]
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Tumor microvasculature with endothelial fenestrations in VHL null clear cell renal cell carcinomas as a potent target of anti-angiogenic therapy. Yamasaki T, Kamba T, Kanno T, Inoue T, Shibasaki N, Arakaki R, Yamada T, Kondo K, Kamoto T, Nishiyama H, Ogawa O, Nakamura E. Cancer science. 2012 103:2027-37. (WB; Human) [PubMed:22931246]
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Hypoxia regulates CD44 and its variant isoforms through HIF-1 in triple negative breast cancer. Krishnamachary B, Penet MF, Nimmagadda S, Mironchik Y, Raman V, Solaiyappan M, Semenza GL, Pomper MG, Bhujwalla ZM. PloS one. 2012 7:e44078. (WB; Human) [PubMed:22937154] [PMC:PMC3429433]
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Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma. Croci DO, Salatino M, Rubinstein N, Cerliani JP, Cavallin LE, Leung HJ, Ouyang J, Ilarregui JM, Toscano MA, Domaica CI, Croci MC, Shipp MA, Mesri EA, Albini A, Rabinovich GA. The Journal of experimental medicine. 2012 209:1985-2000. (WB; Human) [PubMed:23027923] [PMC:PMC3478924]
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The accumulations of HIF-1 and HIF-2 by JNK and ERK are involved in biphasic effects induced by different levels of arsenite in human bronchial epithelial cells. Xu Y, Li Y, Li H, Pang Y, Zhao Y, Jiang R, Shen L, Zhou J, Wang X, Liu Q. Toxicology and applied pharmacology. 2013 266:187-97. (WB; Human) [PubMed:23194660]
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Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer. Vanharanta S, Shu W, Brenet F, Hakimi AA, Heguy A, Viale A, Reuter VE, Hsieh JJ, Scandura JM, Massagu J. Nature medicine. 2013 19:50-6. (WB; Mouse) [PubMed:23223005] [PMC:PMC3540187]
257
Silencing of GLUT-1 inhibits sensitization of oral cancer cells to cisplatin during hypoxia. Grasselli G, Mandolesi G, Strata P, Cesare P. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 2012 (WB; Human) [PubMed:23227892]
258
Effects of exposure to a DNA damaging agent on the hypoxia inducible factors in organogenesis stage mouse limbs. Huang C, Hales BF. PloS one. 2012 7:e51937. (IHC, WB; Mouse) [PubMed:23251655] [PMC:PMC3522594]
259
Silencing of int6 gene restores function of the ischaemic hindlimb in a rat model of peripheral arterial disease. Okamoto N, Tanaka A, Jung K, Karasawa K, Orito K, Matsuda A, Amagai Y, Oida K, Ohmori K, Matsuda H. Cardiovascular research. 2011 Nov;92:209-17. [Full Text Article] [PubMed:21771896] Related Antibodies: LS-B501.
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Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
HIF2A / EPAS1 Mouse IgG1 Monoclonal ep190b Unconjugated,Biotin Conjugated,DY550 Conjugated,DY488 Conjugated,DY650 Conjugated Human, Mouse, Rat IHC-P, WB,IHC, IHC-P, WB,IHC, IHC-P, WB, Flo,IHC, IHC-P, WB, Flo,IHC, IHC-P, WB, Flo aa535-631
5
HIF2A / EPAS1 Mouse IgG1 Monoclonal ep190b Unconjugated Human, Mouse, Rat IHC-P, WB aa535-631 Yes Primary
Anti-HIF2A / EPAS1 Antibody (aa535-631, clone ep190b) IHC-plus™ LS-B501
PublicationsPublications (1)
Immunohistochemistry Image
Mouse Monoclonal [clone ep190b] (IgG1) to Human HIF2A / EPAS1
Human, Mouse, Rat
IHC - Paraffin, Western blot
Unconjugated
HIF2A / EPAS1 Mouse IgG1 Monoclonal Ep190b Biotin Conjugated Human, Mouse, Rat, Hamster IHC, IHC-P, WB aa535-631 No Primary
Anti-HIF2A / EPAS1 Antibody (aa535-631, clone Ep190b, Biotin) LS-C140825
Immunohistochemistry Image
Western blot Image
Mouse Monoclonal [clone Ep190b] (IgG1) to Human HIF2A / EPAS1
Human, Mouse, Rat, Hamster
IHC, IHC - Paraffin, Western blot
Biotin Conjugated
HIF2A / EPAS1 Mouse IgG1 Monoclonal Ep190b DY550 Conjugated Human, Mouse, Rat IHC, IHC-P, WB, Flo aa535-631 No Primary
Anti-HIF2A / EPAS1 Antibody (aa535-631, clone Ep190b, DY550) LS-C140828
Immunohistochemistry Image
Western blot Image
Mouse Monoclonal [clone Ep190b] (IgG1) to Human HIF2A / EPAS1
Human, Mouse, Rat
IHC, IHC - Paraffin, Western blot, Flow Cytometry
DY550 Conjugated
HIF2A / EPAS1 Mouse IgG1 Monoclonal Ep190b DY488 Conjugated Human, Mouse, Rat IHC, IHC-P, WB, Flo aa535-631 No Primary
Anti-HIF2A / EPAS1 Antibody (aa535-631, clone Ep190b, DY488) LS-C140827
Immunohistochemistry Image
Western blot Image
Mouse Monoclonal [clone Ep190b] (IgG1) to Human HIF2A / EPAS1
Human, Mouse, Rat
IHC, IHC - Paraffin, Western blot, Flow Cytometry
DY488 Conjugated
HIF2A / EPAS1 Mouse IgG1 Monoclonal Ep190b DY650 Conjugated Human, Mouse, Rat IHC, IHC-P, WB, Flo aa535-631 No Primary
Anti-HIF2A / EPAS1 Antibody (aa535-631, clone Ep190b, DY650) LS-C140826
Immunohistochemistry Image
Western blot Image
Mouse Monoclonal [clone Ep190b] (IgG1) to Human HIF2A / EPAS1
Human, Mouse, Rat
IHC, IHC - Paraffin, Western blot, Flow Cytometry
DY650 Conjugated
HIF2A / EPAS1 Rabbit Polyclonal Unconjugated Human IHC-P, ICC, IF, WB
1
HIF2A / EPAS1 Rabbit Polyclonal Unconjugated Human IHC-P, ICC, IF, WB No Primary
Anti-HIF2A / EPAS1 Antibody IHC-plus™ LS-B4223
Immunohistochemistry Image
Immunofluorescence Image
Rabbit Polyclonal to Human HIF2A / EPAS1
Human
IHC - Paraffin, ICC, Immunofluorescence, Western blot
Unconjugated
HIF2A / EPAS1 Rabbit Polyclonal Unconjugated,Biotin Conjugated,DY650 Conjugated,DY550 Conjugated,DY488 Conjugated Human, Mouse, Rat, Hamster, Sheep, Fish, Primate IHC-P,IHC, IHC-P, WB,IHC, IHC-P, WB,IHC, IHC-P, WB,IHC, IHC-P, WB C-Terminus
5
HIF2A / EPAS1 Rabbit Polyclonal Unconjugated Human, Mouse, Rat, Hamster, Sheep, Fish, Primate IHC-P C-Terminus No Primary
Anti-HIF2A / EPAS1 Antibody (C-Terminus) IHC-plus™ LS-B517
Immunohistochemistry Image
Rabbit Polyclonal to Human HIF2A / EPAS1
Human, Mouse, Rat, Hamster, Sheep, Fish, Primate
IHC - Paraffin
Unconjugated
HIF2A / EPAS1 Rabbit Polyclonal Biotin Conjugated Human, Mouse, Rat, Hamster, Sheep, Fish, Primate IHC, IHC-P, WB C-Terminus No Primary
Anti-HIF2A / EPAS1 Antibody (C-Terminus, Biotin) LS-C83703
Immunohistochemistry Image
Immunocytochemistry Image
Rabbit Polyclonal to Human HIF2A / EPAS1
Human, Mouse, Rat, Hamster, Sheep, Fish, Primate
IHC, IHC - Paraffin, Western blot
Biotin Conjugated
HIF2A / EPAS1 Rabbit Polyclonal DY650 Conjugated Human, Mouse, Rat, Fish IHC, IHC-P, WB C-Terminus No Primary
Anti-HIF2A / EPAS1 Antibody (C-Terminus, DY650) LS-C140799
Immunohistochemistry Image
Immunocytochemistry Image
Rabbit Polyclonal to Human HIF2A / EPAS1
Human, Mouse, Rat, Fish
IHC, IHC - Paraffin, Western blot
DY650 Conjugated
HIF2A / EPAS1 Rabbit Polyclonal DY550 Conjugated Human, Mouse, Rat, Fish IHC, IHC-P, WB C-Terminus No Primary
Anti-HIF2A / EPAS1 Antibody (C-Terminus, DY550) LS-C140801
Immunohistochemistry Image
Immunocytochemistry Image
Rabbit Polyclonal to Human HIF2A / EPAS1
Human, Mouse, Rat, Fish
IHC, IHC - Paraffin, Western blot
DY550 Conjugated
HIF2A / EPAS1 Rabbit Polyclonal DY488 Conjugated Human, Mouse, Rat, Fish IHC, IHC-P, WB C-Terminus No Primary
Anti-HIF2A / EPAS1 Antibody (C-Terminus, DY488) LS-C140800
Immunohistochemistry Image
Immunocytochemistry Image
Rabbit Polyclonal to Human HIF2A / EPAS1
Human, Mouse, Rat, Fish
IHC, IHC - Paraffin, Western blot
DY488 Conjugated
HIF2A / EPAS1 Goat IgG Polyclonal Unconjugated Human, Mouse, Rat IHC-Fr, WB
1
HIF2A / EPAS1 Goat IgG Polyclonal Unconjugated Human, Mouse, Rat IHC-Fr, WB No Primary
Anti-HIF2A / EPAS1 Antibody LS-C150132
Western blot Image
Goat Polyclonal (IgG) to Human HIF2A / EPAS1
Human, Mouse, Rat
IHC - Frozen, Western blot
Unconjugated
HIF2A / EPAS1 Mouse IgG2b Monoclonal Hif2alpha237 Unconjugated Human IHC-P
1
HIF2A / EPAS1 Mouse IgG2b Monoclonal Hif2alpha237 Unconjugated Human IHC-P No Primary
Anti-HIF2A / EPAS1 Antibody (clone Hif2alpha237) LS-C188630
Mouse Monoclonal [clone Hif2alpha237] (IgG2b) to Human HIF2A / EPAS1
Human
IHC - Paraffin
Unconjugated
HIF2A / EPAS1 Mouse IgG1 Monoclonal EP190b Unconjugated Human IHC-P, IHC-Fr, ICC, WB
1
HIF2A / EPAS1 Mouse IgG1 Monoclonal EP190b Unconjugated Human IHC-P, IHC-Fr, ICC, WB No Primary
Anti-HIF2A / EPAS1 Antibody (clone EP190b) IHC-plus™ LS-B10429
Immunohistochemistry Image
Immunohistochemistry Image
Mouse Monoclonal [clone EP190b] (IgG1)
Human
IHC - Paraffin, IHC - Frozen, ICC, Western blot
Unconjugated
HIF2A / EPAS1 Rabbit Polyclonal Unconjugated Human, Mouse, Rat IHC, WB, IP C-Terminus
1
HIF2A / EPAS1 Rabbit Polyclonal Unconjugated Human, Mouse, Rat IHC, WB, IP C-Terminus No Primary
Anti-HIF2A / EPAS1 Antibody (C-Terminus) LS-C123798
Rabbit Polyclonal to Human HIF2A / EPAS1
Human, Mouse, Rat
IHC, Western blot, Immunoprecipitation
Unconjugated
HIF2A / EPAS1 Mouse IgG1 Monoclonal EP190b Unconjugated,Biotin Conjugated,FITC Conjugated,Atto 594 Conjugated,Atto 488 Conjugated,Atto 565 Conjugated,Atto 390 Conjugated,PE, Atto 594 Conjugated,SA Conjugated,RPE Conjugated,PerCP Conjugated,Atto 680 Conjugated,Atto 655 Conjugated,Atto 633 Conjugated,Atto 700 Conjugated,APC Conjugated,AP Conjugated Human IHC-P, ICC, WB, ELISA,IHC, IHC-P, ICC, IF, WB, ELISA,IHC, IHC-P, ICC, IF, WB, ELISA,IHC, IHC-P, ICC, IF, WB, ELISA,IHC, IHC-P, ICC, IF, WB, ELISA,IHC, IHC-P, ICC, IF, WB, ELISA,IHC, IHC-P, ICC, IF, WB, ELISA,IHC, IHC-P, ICC, IF, WB, ELISA,IHC, IHC-P, ICC, IF, WB, ELISA,IHC, IHC-P, ICC, IF, WB, ELISA,IHC, IHC-P, ICC, IF, WB, ELISA,IHC, IHC-P, ICC, IF, WB, ELISA,IHC, IHC-P, ICC, IF, WB, ELISA,IHC, IHC-P, ICC, IF, WB, ELISA,IHC, IHC-P, ICC, IF, WB, ELISA,IHC, IHC-P, ICC, IF, WB, ELISA,IHC, IHC-P, ICC, IF, WB, ELISA
17
HIF2A / EPAS1 Mouse IgG1 Monoclonal EP190b Unconjugated Human IHC-P, ICC, WB, ELISA No Primary
Anti-HIF2A / EPAS1 Antibody (clone EP190b) IHC-plus™ LS-B8145
Immunohistochemistry Image
Immunohistochemistry Image
Mouse Monoclonal [clone EP190b] (IgG1) to Human HIF2A / EPAS1
Human
IHC - Paraffin, ICC, Western blot, ELISA
Unconjugated
HIF2A / EPAS1 Mouse IgG1 Monoclonal EP190b Biotin Conjugated Human IHC, IHC-P, ICC, IF, WB, ELISA aa535-631 No Primary
Anti-HIF2A / EPAS1 Antibody (aa535-631, clone EP190b, Biotin) LS-C227501
Immunohistochemistry Image
Immunohistochemistry Image
Mouse Monoclonal [clone EP190b] (IgG1) to Human HIF2A / EPAS1
Human
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, ELISA
Biotin Conjugated
HIF2A / EPAS1 Mouse IgG1 Monoclonal EP190b FITC Conjugated Human IHC, IHC-P, ICC, IF, WB, ELISA aa535-631 No Primary
Anti-HIF2A / EPAS1 Antibody (aa535-631, clone EP190b, FITC) LS-C227502
Immunohistochemistry Image
Immunohistochemistry Image
Mouse Monoclonal [clone EP190b] (IgG1) to Human HIF2A / EPAS1
Human
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, ELISA
FITC Conjugated
HIF2A / EPAS1 Mouse IgG1 Monoclonal EP190b Atto 594 Conjugated Human IHC, IHC-P, ICC, IF, WB, ELISA aa535-631 No Primary
Anti-HIF2A / EPAS1 Antibody (aa535-631, clone EP190b, Atto 594) LS-C227494
Immunohistochemistry Image
Immunohistochemistry Image
Mouse Monoclonal [clone EP190b] (IgG1) to Human HIF2A / EPAS1
Human
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, ELISA
Atto 594 Conjugated
HIF2A / EPAS1 Mouse IgG1 Monoclonal EP190b Atto 488 Conjugated Human IHC, IHC-P, ICC, IF, WB, ELISA aa535-631 No Primary
Anti-HIF2A / EPAS1 Antibody (aa535-631, clone EP190b, Atto 488) LS-C227493
Immunohistochemistry Image
Immunohistochemistry Image
Mouse Monoclonal [clone EP190b] (IgG1) to Human HIF2A / EPAS1
Human
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, ELISA
Atto 488 Conjugated
HIF2A / EPAS1 Mouse IgG1 Monoclonal EP190b Atto 565 Conjugated Human IHC, IHC-P, ICC, IF, WB, ELISA aa535-631 No Primary
Anti-HIF2A / EPAS1 Antibody (aa535-631, clone EP190b, Atto 565) LS-C227492
Immunohistochemistry Image
Immunohistochemistry Image
Mouse Monoclonal [clone EP190b] (IgG1) to Human HIF2A / EPAS1
Human
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, ELISA
Atto 565 Conjugated
HIF2A / EPAS1 Mouse IgG1 Monoclonal EP190b Atto 390 Conjugated Human IHC, IHC-P, ICC, IF, WB, ELISA aa535-631 No Primary
Anti-HIF2A / EPAS1 Antibody (aa535-631, clone EP190b, Atto 390) LS-C227491
Immunohistochemistry Image
Immunohistochemistry Image
Mouse Monoclonal [clone EP190b] (IgG1) to Human HIF2A / EPAS1
Human
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, ELISA
Atto 390 Conjugated
HIF2A / EPAS1 Mouse IgG1 Monoclonal EP190b PE, Atto 594 Conjugated Human IHC, IHC-P, ICC, IF, WB, ELISA aa535-631 No Primary
Anti-HIF2A / EPAS1 Antibody (aa535-631, clone EP190b, PE, Atto 594) LS-C227504
Immunohistochemistry Image
Immunohistochemistry Image
Mouse Monoclonal [clone EP190b] (IgG1) to Human HIF2A / EPAS1
Human
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, ELISA
PE, Atto 594 Conjugated
HIF2A / EPAS1 Mouse IgG1 Monoclonal EP190b SA Conjugated Human IHC, IHC-P, ICC, IF, WB, ELISA aa535-631 No Primary
Anti-HIF2A / EPAS1 Antibody (aa535-631, clone EP190b, SA) LS-C227507
Immunohistochemistry Image
Immunohistochemistry Image
Mouse Monoclonal [clone EP190b] (IgG1) to Human HIF2A / EPAS1
Human
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, ELISA
SA Conjugated
HIF2A / EPAS1 Mouse IgG1 Monoclonal EP190b RPE Conjugated Human IHC, IHC-P, ICC, IF, WB, ELISA aa535-631 No Primary
Anti-HIF2A / EPAS1 Antibody (aa535-631, clone EP190b, RPE) LS-C227506
Immunohistochemistry Image
Immunohistochemistry Image
Mouse Monoclonal [clone EP190b] (IgG1) to Human HIF2A / EPAS1
Human
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, ELISA
RPE Conjugated
HIF2A / EPAS1 Mouse IgG1 Monoclonal EP190b PerCP Conjugated Human IHC, IHC-P, ICC, IF, WB, ELISA aa535-631 No Primary
Anti-HIF2A / EPAS1 Antibody (aa535-631, clone EP190b, PerCP) LS-C227505
Immunohistochemistry Image
Immunohistochemistry Image
Mouse Monoclonal [clone EP190b] (IgG1) to Human HIF2A / EPAS1
Human
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, ELISA
PerCP Conjugated
HIF2A / EPAS1 Mouse IgG1 Monoclonal EP190b Atto 680 Conjugated Human IHC, IHC-P, ICC, IF, WB, ELISA aa535-631 No Primary
Anti-HIF2A / EPAS1 Antibody (aa535-631, clone EP190b, Atto 680) LS-C227497
Immunohistochemistry Image
Immunohistochemistry Image
Mouse Monoclonal [clone EP190b] (IgG1) to Human HIF2A / EPAS1
Human
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, ELISA
Atto 680 Conjugated
HIF2A / EPAS1 Mouse IgG1 Monoclonal EP190b Atto 655 Conjugated Human IHC, IHC-P, ICC, IF, WB, ELISA aa535-631 No Primary
Anti-HIF2A / EPAS1 Antibody (aa535-631, clone EP190b, Atto 655) LS-C227496
Immunohistochemistry Image
Immunohistochemistry Image
Mouse Monoclonal [clone EP190b] (IgG1) to Human HIF2A / EPAS1
Human
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, ELISA
Atto 655 Conjugated
HIF2A / EPAS1 Mouse IgG1 Monoclonal EP190b Atto 633 Conjugated Human IHC, IHC-P, ICC, IF, WB, ELISA aa535-631 No Primary
Anti-HIF2A / EPAS1 Antibody (aa535-631, clone EP190b, Atto 633) LS-C227495
Immunohistochemistry Image
Immunohistochemistry Image
Mouse Monoclonal [clone EP190b] (IgG1) to Human HIF2A / EPAS1
Human
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, ELISA
Atto 633 Conjugated
HIF2A / EPAS1 Mouse IgG1 Monoclonal EP190b Atto 700 Conjugated Human IHC, IHC-P, ICC, IF, WB, ELISA aa535-631 No Primary
Anti-HIF2A / EPAS1 Antibody (aa535-631, clone EP190b, Atto 700) LS-C227498
Immunohistochemistry Image
Immunohistochemistry Image
Mouse Monoclonal [clone EP190b] (IgG1) to Human HIF2A / EPAS1
Human
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, ELISA
Atto 700 Conjugated
HIF2A / EPAS1 Mouse IgG1 Monoclonal EP190b APC Conjugated Human IHC, IHC-P, ICC, IF, WB, ELISA aa535-631 No Primary
Anti-HIF2A / EPAS1 Antibody (aa535-631, clone EP190b, APC) LS-C227500
Immunohistochemistry Image
Immunohistochemistry Image
Mouse Monoclonal [clone EP190b] (IgG1) to Human HIF2A / EPAS1
Human
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, ELISA
APC Conjugated
HIF2A / EPAS1 Mouse IgG1 Monoclonal EP190b AP Conjugated Human IHC, IHC-P, ICC, IF, WB, ELISA aa535-631 No Primary
Anti-HIF2A / EPAS1 Antibody (aa535-631, clone EP190b, AP) LS-C227499
Immunohistochemistry Image
Immunohistochemistry Image
Mouse Monoclonal [clone EP190b] (IgG1) to Human HIF2A / EPAS1
Human
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, ELISA
AP Conjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, IF, WB, ELISA aa380-420
1
HIF2A / EPAS1 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, IF, WB, ELISA aa380-420 No Primary
Anti-HIF2A / EPAS1 Antibody (aa380-420) LS-C387091
Immunohistochemistry Image
Immunohistochemistry Image
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human, Mouse, Rat
IHC, Immunofluorescence, Western blot, ELISA
Unconjugated
HIF2A / EPAS1 Rabbit Polyclonal Unconjugated,HRP Conjugated,Biotin Conjugated,FITC Conjugated Human, Monkey, Mouse, Bat, Bovine, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Chicken, Xenopus WB,WB,WB,WB aa360-409
4
HIF2A / EPAS1 Rabbit Polyclonal Unconjugated Human, Monkey, Mouse, Bat, Bovine, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Chicken, Xenopus WB aa360-409 No Primary Available
Anti-HIF2A / EPAS1 Antibody (aa360-409) LS-C109647
Western blot Image
Rabbit Polyclonal to Human HIF2A / EPAS1
Human, Monkey, Mouse, Bat, Bovine, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Chicken, Xenopus
Western blot
Unconjugated
HIF2A / EPAS1 Rabbit Polyclonal HRP Conjugated Human, Chimpanzee, Orangutan, Gibbon, Monkey, Mouse, Bat, Bovine, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Chicken, Xenopus WB aa360-409 No Primary
Anti-HIF2A / EPAS1 Antibody (aa360-409, HRP) LS-C427545
Western blot Image
Rabbit Polyclonal to Human HIF2A / EPAS1
Human, Chimpanzee, Orangutan, Gibbon, Monkey, Mouse, Bat, Bovine, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Chicken, Xenopus
Western blot
HRP Conjugated
HIF2A / EPAS1 Rabbit Polyclonal Biotin Conjugated Human, Chimpanzee, Orangutan, Gibbon, Monkey, Mouse, Bat, Bovine, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Chicken, Xenopus WB aa360-409 No Primary
Anti-HIF2A / EPAS1 Antibody (aa360-409, Biotin) LS-C427543
Western blot Image
Rabbit Polyclonal to Human HIF2A / EPAS1
Human, Chimpanzee, Orangutan, Gibbon, Monkey, Mouse, Bat, Bovine, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Chicken, Xenopus
Western blot
Biotin Conjugated
HIF2A / EPAS1 Rabbit Polyclonal FITC Conjugated Human, Chimpanzee, Orangutan, Gibbon, Monkey, Mouse, Bat, Bovine, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Chicken, Xenopus WB aa360-409 No Primary
Anti-HIF2A / EPAS1 Antibody (aa360-409, FITC) LS-C427544
Western blot Image
Rabbit Polyclonal to Human HIF2A / EPAS1
Human, Chimpanzee, Orangutan, Gibbon, Monkey, Mouse, Bat, Bovine, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Chicken, Xenopus
Western blot
FITC Conjugated
HIF2A / EPAS1 Mouse IgG1,k Monoclonal 1G2 Unconjugated Human IF, WB, ELISA
1
HIF2A / EPAS1 Mouse IgG1,k Monoclonal 1G2 Unconjugated Human IF, WB, ELISA No Primary
Anti-HIF2A / EPAS1 Antibody (clone 1G2) LS-C197138
Immunofluorescence Image
Western blot Image
Mouse Monoclonal [clone 1G2] (IgG1,k) to Human HIF2A / EPAS1
Human
Immunofluorescence, Western blot, ELISA
Unconjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal Unconjugated,HRP Conjugated,Biotin Conjugated,FITC Conjugated,PE Conjugated,AP Conjugated,APC Conjugated Human WB, Flo, ELISA,WB, ELISA,WB, Flo, ELISA,WB, Flo, ELISA,WB, Flo, ELISA,WB, Flo, ELISA,WB, Flo, ELISA aa127-154
7
HIF2A / EPAS1 Rabbit IgG Polyclonal Unconjugated Human WB, Flo, ELISA aa127-154 No Primary
Anti-HIF2A / EPAS1 Antibody (aa127-154) LS-C321132
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Western blot, Flow Cytometry, ELISA
Unconjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal HRP Conjugated Human WB, ELISA No Primary
Anti-HIF2A / EPAS1 Antibody (HRP) LS-C540423
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Western blot, ELISA
HRP Conjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal Biotin Conjugated Human WB, Flo, ELISA No Primary
Anti-HIF2A / EPAS1 Antibody (Biotin) LS-C520234
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Western blot, Flow Cytometry, ELISA
Biotin Conjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal FITC Conjugated Human WB, Flo, ELISA aa124-150 No Primary
Anti-HIF2A / EPAS1 Antibody (aa124-150, FITC) LS-C213812
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Western blot, Flow Cytometry, ELISA
FITC Conjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal PE Conjugated Human WB, Flo, ELISA aa124-150 No Primary
Anti-HIF2A / EPAS1 Antibody (aa124-150, PE) LS-C213814
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Western blot, Flow Cytometry, ELISA
PE Conjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal AP Conjugated Human WB, Flo, ELISA aa124-150 No Primary
Anti-HIF2A / EPAS1 Antibody (aa124-150, AP) LS-C213810
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Western blot, Flow Cytometry, ELISA
AP Conjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal APC Conjugated Human WB, Flo, ELISA aa124-150 No Primary
Anti-HIF2A / EPAS1 Antibody (aa124-150, APC) LS-C213811
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Western blot, Flow Cytometry, ELISA
APC Conjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal Unconjugated Rat, Mouse IHC, ICC, WB aa202-240
1
HIF2A / EPAS1 Rabbit IgG Polyclonal Unconjugated Rat, Mouse IHC, ICC, WB aa202-240 No Primary
Anti-HIF2A / EPAS1 Antibody (aa202-240) LS-C123799
Rabbit Polyclonal (IgG) to Rat HIF2A / EPAS1
Rat, Mouse
IHC, ICC, Western blot
Unconjugated
HIF2A / EPAS1 Goat IgG Polyclonal Unconjugated Mouse IHC, WB aa542-874
1
HIF2A / EPAS1 Goat IgG Polyclonal Unconjugated Mouse IHC, WB aa542-874 No Primary
Anti-HIF2A / EPAS1 Antibody (aa542-874) LS-C143898
Goat Polyclonal (IgG) to Mouse HIF2A / EPAS1
Mouse
IHC, Western blot
Unconjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal Unconjugated Mouse, Human WB, ELISA
1
HIF2A / EPAS1 Rabbit IgG Polyclonal Unconjugated Mouse, Human WB, ELISA No Primary
Anti-HIF2A / EPAS1 Antibody LS-C36839
Rabbit Polyclonal (IgG) to Mouse HIF2A / EPAS1
Mouse, Human
Western blot, ELISA
Unconjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal Unconjugated Human IF, WB
1
HIF2A / EPAS1 Rabbit IgG Polyclonal Unconjugated Human IF, WB No Primary
Anti-HIF2A / EPAS1 Antibody LS-C409163
Immunofluorescence Image
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Immunofluorescence, Western blot
Unconjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal Unconjugated,Biotin Conjugated,FITC Conjugated Mouse WB, ELISA,WB, ELISA,WB, ELISA aa21-336
3
HIF2A / EPAS1 Rabbit IgG Polyclonal Unconjugated Mouse WB, ELISA aa21-336 No Primary
Anti-HIF2A / EPAS1 Antibody (aa21-336) LS-C294557
Western blot Image
Rabbit Polyclonal (IgG) to Mouse HIF2A / EPAS1
Mouse
Western blot, ELISA
Unconjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal Biotin Conjugated Mouse WB, ELISA aa21-336 No Primary
Anti-HIF2A / EPAS1 Antibody (aa21-336, Biotin) LS-C299617
Western blot Image
Rabbit Polyclonal (IgG) to Mouse HIF2A / EPAS1
Mouse
Western blot, ELISA
Biotin Conjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal FITC Conjugated Mouse WB, ELISA aa21-336 No Primary
Anti-HIF2A / EPAS1 Antibody (aa21-336, FITC) LS-C302458
Western blot Image
Rabbit Polyclonal (IgG) to Mouse HIF2A / EPAS1
Mouse
Western blot, ELISA
FITC Conjugated
HIF2A / EPAS1 Rabbit Polyclonal Unconjugated Mouse WB, ELISA aa713-747
1
HIF2A / EPAS1 Rabbit Polyclonal Unconjugated Mouse WB, ELISA aa713-747 No Primary
Anti-HIF2A / EPAS1 Antibody (aa713-747) LS-C392718
Western blot Image
Rabbit Polyclonal to Mouse HIF2A / EPAS1
Mouse
Western blot, ELISA
Unconjugated
HIF2A / EPAS1 Rabbit Polyclonal Unconjugated Human WB, Flo aa124-150
1
HIF2A / EPAS1 Rabbit Polyclonal Unconjugated Human WB, Flo aa124-150 No Primary Available
Anti-HIF2A / EPAS1 Antibody (aa124-150) LS-C167780
Western blot Image
Flow Cytometry Image
Rabbit Polyclonal to Human HIF2A / EPAS1
Human
Western blot, Flow Cytometry
Unconjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal Unconjugated,HRP Conjugated,Biotin Conjugated,FITC Conjugated,AP Conjugated,APC Conjugated,PE Conjugated Human WB, ELISA,WB, ELISA,WB, ELISA,WB, ELISA,WB, ELISA,WB, ELISA,WB, ELISA aa576-625
7
HIF2A / EPAS1 Rabbit IgG Polyclonal Unconjugated Human WB, ELISA aa576-625 No Primary
Anti-HIF2A / EPAS1 Antibody (aa576-625) LS-C321128
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Western blot, ELISA
Unconjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal HRP Conjugated Human WB, ELISA No Primary
Anti-HIF2A / EPAS1 Antibody (HRP) LS-C540421
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Western blot, ELISA
HRP Conjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal Biotin Conjugated Human WB, ELISA No Primary
Anti-HIF2A / EPAS1 Antibody (Biotin) LS-C520235
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Western blot, ELISA
Biotin Conjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal FITC Conjugated Human WB, ELISA aa577-605 No Primary
Anti-HIF2A / EPAS1 Antibody (aa577-605, FITC) LS-C213809
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Western blot, ELISA
FITC Conjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal AP Conjugated Human WB, ELISA aa577-605 No Primary
Anti-HIF2A / EPAS1 Antibody (aa577-605, AP) LS-C213806
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Western blot, ELISA
AP Conjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal APC Conjugated Human WB, ELISA aa577-605 No Primary
Anti-HIF2A / EPAS1 Antibody (aa577-605, APC) LS-C213807
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Western blot, ELISA
APC Conjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal PE Conjugated Human WB, ELISA aa577-605 No Primary
Anti-HIF2A / EPAS1 Antibody (aa577-605, PE) LS-C213808
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Western blot, ELISA
PE Conjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal Unconjugated,Biotin Conjugated,FITC Conjugated Human WB, ELISA,WB, ELISA,WB, ELISA aa339-541
3
HIF2A / EPAS1 Rabbit IgG Polyclonal Unconjugated Human WB, ELISA aa339-541 No Primary
Anti-HIF2A / EPAS1 Antibody (aa339-541) LS-C294556
Western blot Image
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Western blot, ELISA
Unconjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal Biotin Conjugated Human WB, ELISA aa339-541 No Primary
Anti-HIF2A / EPAS1 Antibody (aa339-541, Biotin) LS-C299616
Western blot Image
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Western blot, ELISA
Biotin Conjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal FITC Conjugated Human WB, ELISA aa339-541 No Primary
Anti-HIF2A / EPAS1 Antibody (aa339-541, FITC) LS-C302456
Western blot Image
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Western blot, ELISA
FITC Conjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal Unconjugated,Biotin Conjugated,FITC Conjugated Rat WB, ELISA,WB, ELISA,WB, ELISA aa24-348
3
HIF2A / EPAS1 Rabbit IgG Polyclonal Unconjugated Rat WB, ELISA aa24-348 No Primary
Anti-HIF2A / EPAS1 Antibody (aa24-348) LS-C294562
Western blot Image
Rabbit Polyclonal (IgG) to Rat HIF2A / EPAS1
Rat
Western blot, ELISA
Unconjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal Biotin Conjugated Rat WB, ELISA aa24-348 No Primary
Anti-HIF2A / EPAS1 Antibody (aa24-348, Biotin) LS-C297127
Western blot Image
Rabbit Polyclonal (IgG) to Rat HIF2A / EPAS1
Rat
Western blot, ELISA
Biotin Conjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal FITC Conjugated Rat WB, ELISA aa24-348 No Primary
Anti-HIF2A / EPAS1 Antibody (aa24-348, FITC) LS-C303882
Western blot Image
Rabbit Polyclonal (IgG) to Rat HIF2A / EPAS1
Rat
Western blot, ELISA
FITC Conjugated
HIF2A / EPAS1 Mouse IgG2a Monoclonal Unconjugated Human WB aa543-870
1
HIF2A / EPAS1 Mouse IgG2a Monoclonal Unconjugated Human WB aa543-870 No Primary
Anti-HIF2A / EPAS1 Antibody (aa543-870) LS-C129907
Mouse Monoclonal (IgG2a) to Human HIF2A / EPAS1
Human
Western blot
Unconjugated
HIF2A / EPAS1 Mouse IgG1 Monoclonal 2G5 Unconjugated Human WB aa584-870
1
HIF2A / EPAS1 Mouse IgG1 Monoclonal 2G5 Unconjugated Human WB aa584-870 No Primary
Anti-HIF2A / EPAS1 Antibody (aa584-870, clone 2G5) LS-C336401
Western blot Image
Mouse Monoclonal [clone 2G5] (IgG1) to Human HIF2A / EPAS1
Human
Western blot
Unconjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal Unconjugated,HRP Conjugated,Biotin Conjugated,FITC Conjugated,AP Conjugated,APC Conjugated,PE Conjugated Human WB,WB,WB,WB,WB,WB,WB
7
HIF2A / EPAS1 Rabbit IgG Polyclonal Unconjugated Human WB No Primary
Anti-HIF2A / EPAS1 Antibody LS-C310266
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Western blot
Unconjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal HRP Conjugated Human WB No Primary
Anti-HIF2A / EPAS1 Antibody (HRP) LS-C541989
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Western blot
HRP Conjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal Biotin Conjugated Human WB No Primary
Anti-HIF2A / EPAS1 Antibody (Biotin) LS-C521858
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Western blot
Biotin Conjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal FITC Conjugated Human WB No Primary
Anti-HIF2A / EPAS1 Antibody (FITC) LS-C531902
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Western blot
FITC Conjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal AP Conjugated Human WB No Primary
Anti-HIF2A / EPAS1 Antibody (AP) LS-C503934
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Western blot
AP Conjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal APC Conjugated Human WB No Primary
Anti-HIF2A / EPAS1 Antibody (APC) LS-C513644
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Western blot
APC Conjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal PE Conjugated Human WB No Primary
Anti-HIF2A / EPAS1 Antibody (PE) LS-C650102
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human
Western blot
PE Conjugated
HIF2A / EPAS1 Rabbit Polyclonal Unconjugated Human WB aa547-551
1
HIF2A / EPAS1 Rabbit Polyclonal Unconjugated Human WB aa547-551 No Primary
Anti-HIF2A / EPAS1 Antibody (aa547-551) LS-C205424
Rabbit Polyclonal to Human HIF2A / EPAS1
Human
Western blot
Unconjugated
HIF2A / EPAS1 Rabbit Polyclonal Unconjugated Human WB aa577-605
1
HIF2A / EPAS1 Rabbit Polyclonal Unconjugated Human WB aa577-605 No Primary Available
Anti-HIF2A / EPAS1 Antibody (aa577-605) LS-C167779
Western blot Image
Rabbit Polyclonal to Human HIF2A / EPAS1
Human
Western blot
Unconjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal Unconjugated Human, Orangutan, Monkey, Mouse, Rat, Bovine, Horse, Sheep WB aa282-301
1
HIF2A / EPAS1 Rabbit IgG Polyclonal Unconjugated Human, Orangutan, Monkey, Mouse, Rat, Bovine, Horse, Sheep WB aa282-301 No Primary
Anti-HIF2A / EPAS1 Antibody (aa282-301) LS-C343868
Western blot Image
Rabbit Polyclonal (IgG) to Human HIF2A / EPAS1
Human, Orangutan, Monkey, Mouse, Rat, Bovine, Horse, Sheep
Western blot
Unconjugated
HIF2A / EPAS1 Rabbit IgG Polyclonal Unconjugated Rat, Orangutan IHC-P, WB aa202-240
1
HIF2A / EPAS1 Rabbit IgG Polyclonal Unconjugated Rat, Orangutan IHC-P, WB aa202-240 No Primary
Anti-HIF2A / EPAS1 Antibody (aa202-240) LS-C344095
Immunohistochemistry Image
Western blot Image
Rabbit Polyclonal (IgG) to Rat HIF2A / EPAS1
Rat, Orangutan
IHC - Paraffin, Western blot
Unconjugated
HIF2A / EPAS1 Rabbit Polyclonal Sepharose Conjugated,Magnetic beads Conjugated Rat IP,IP aa202-240
2
HIF2A / EPAS1 Rabbit Polyclonal Sepharose Conjugated Rat IP aa202-240 No Primary
Anti-HIF2A / EPAS1 Antibody (aa202-240, Sepharose) LS-C171930
Immunohistochemistry Image
Western blot Image
Rabbit Polyclonal to Rat HIF2A / EPAS1
Rat
Immunoprecipitation
Sepharose Conjugated
HIF2A / EPAS1 Rabbit Polyclonal Magnetic beads Conjugated Rat IP aa202-240 No Primary
Anti-HIF2A / EPAS1 Antibody (aa202-240, Magnetic beads) LS-C171929
Immunohistochemistry Image
Western blot Image
Rabbit Polyclonal to Rat HIF2A / EPAS1
Rat
Immunoprecipitation
Magnetic beads Conjugated
Target Corresponding Antibodies
HIF2A / EPAS1
1
HIF2A / EPAS1 Antibody Blocking Peptide - LS-E427
LS-E427
HIF2A / EPAS1
LS-C167780
HIF2A / EPAS1
1
HIF2A / EPAS1 Antibody Blocking Peptide - LS-E3055
LS-E3055
HIF2A / EPAS1
LS-C167779
HIF2A / EPAS1
1
HIF2A / EPAS1 Antibody Blocking Peptide - LS-E11270
LS-E11270
HIF2A / EPAS1
LS-C109647
Type Target Reactivity Sample Type
Sandwich HIF2A / EPAS1 Human Cell Culture Supernatants, Cell Lysates, Serum, Tissue Homogenates, Plasma
1
Human HIF2A / EPAS1 ELISA Kit (Sandwich ELISA) - LS-F6738
 Image
 Image
Sandwich ELISA
96-Well Strip Plate
Human
0.156-10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Serum, Tissue Homogenates, Plasma
Sandwich HIF2A / EPAS1 Mouse Cell Culture Supernatants, Cell Lysates, Serum, Tissue Homogenates, Plasma
1
Mouse HIF2A / EPAS1 ELISA Kit (Sandwich ELISA) - LS-F6739
 Image
 Image
Sandwich ELISA
96-Well Strip Plate
Mouse
0.156-10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Serum, Tissue Homogenates, Plasma
Sandwich HIF2A / EPAS1 Human Cell Culture Supernatants, Serum, Tissue Homogenates, Plasma
1
Human HIF2A / EPAS1 ELISA Kit (Sandwich ELISA) - LS-F13165
 Image
 Image
Quantitative Sandwich ELISA
96-Well Strip Plate
Human
0.156-10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Serum, Tissue Homogenates, Plasma
Sandwich HIF2A / EPAS1 Rat Cell Lysates, Tissue Homogenates
1
Rat HIF2A / EPAS1 ELISA Kit (Sandwich ELISA) - LS-F9117
 Image
 Image
Sandwich ELISA
96-Well Strip Plate
Rat
78.13-5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
Sandwich (Custom) HIF2A / EPAS1 Mouse
1
Mouse HIF2A / EPAS1 ELISA Kit (Sandwich ELISA) (Custom) - LS-F19020
 Image
 Image
Sandwich ELISA
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
Sandwich (Custom) HIF2A / EPAS1 Rat
1
Rat HIF2A / EPAS1 ELISA Kit (Sandwich ELISA) (Custom) - LS-F19021
 Image
 Image
Sandwich ELISA
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
Sandwich HIF2A / EPAS1 Mouse Serum, Tissue Homogenates, Plasma
1
Mouse HIF2A / EPAS1 ELISA Kit (Sandwich ELISA) - LS-F32110
 Image
 Image
Quantitative Sandwich ELISA
96-Well Strip Plate
Mouse
78.125-5000 pg/ml
Colorimetric - 450nm (TMB)
Serum, Tissue Homogenates, Plasma
Type Target Tag Species Source Purified Biological Activity Known Endotoxin Level Animal-Free
Recombinant HIF2A / EPAS1 His Rat E. coli Purified
1
Rat HIF2A / EPAS1 Protein (Recombinant His) (aa24-348) - LS-G15332
E. coli Expression System
His
Purified / Lyophilized
aa 24-348
38.5 kDa
Recombinant HIF2A / EPAS1 His Mouse E. coli Purified
1
Mouse HIF2A / EPAS1 Protein (Recombinant His) (aa21-336) - LS-G15334
E. coli Expression System
His
Purified / Lyophilized
aa 21-336
37.5 kDa
Recombinant HIF2A / EPAS1 His Human E. coli Purified Known endotoxin level
1
Human HIF2A / EPAS1 Protein (Recombinant His) (aa339-541) - LS-G15335
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
E. coli Expression System
238 AA
His
Purified / Lyophilized / Endotoxin Level: Less than 1.0 EU/µg protein (determined by LAL method).
aa 339-541
23.6 kDa
Recombinant HIF2A / EPAS1 GST Human Wheat Purified
1
Human HIF2A / EPAS1 Protein (Recombinant GST) - LS-G28356
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
Wheat Wheat Germ Extract
870 AA
GST
Purified
122.1 kDa

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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