HIC1

hypermethylated in cancer 1

Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1.

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Products

Antibodies (27)

Type

Primary (27)

Target

HIC1 (27)

Reactivity

Human (27)

Mouse (8)

Rat (9)

Bat (6)

Bovine (7)

Chimpanzee (3)

Dog (7)

Guinea pig (6)

Hamster (1)

Horse (3)

Monkey (9)

Pig (4)

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Application

IHC (2)

WB (27)

ELISA (8)

IF (1)

Peptide-ELISA (2)

Host

rabbit (24)

mouse (1)

goat (2)

Isotype

IgG (15)

IgG2b,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (26)

Clone

4E11 (1)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (4)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (1)

Unconjugated (13)

Epitope

aa498-527 (7)

aa209-258 (4)

aa215-264 (4)

aa899-948 (4)

aa193-204 (1)

aa396-410 (1)

Publications

No (27)

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HIC1 Antibody (aa209-258) LS-C30180

Antibody:

HIC1 Rabbit anti-Human Polyclonal (aa209-258) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

HIC1 Antibody (aa209-258, HRP) LS-C428223

Antibody:

HIC1 Rabbit anti-Human Polyclonal (aa209-258) (HRP) Antibody

Reactivity:

Mouse, Guinea pig, Rat, Human, Monkey

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

HIC1 Antibody (aa209-258, Biotin) LS-C428221

Antibody:

HIC1 Rabbit anti-Human Polyclonal (aa209-258) (Biotin) Antibody

Reactivity:

Mouse, Guinea pig, Rat, Human, Monkey

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

HIC1 Antibody (aa209-258, FITC) LS-C428222

Antibody:

HIC1 Rabbit anti-Human Polyclonal (aa209-258) (FITC) Antibody

Reactivity:

Mouse, Guinea pig, Rat, Human, Monkey

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

HIC1 Antibody (clone 4E11) LS-C197409

Antibody:

HIC1 Mouse anti-Human Monoclonal (4E11) Antibody

Reactivity:

Rat, Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$423

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HIC1 Antibody LS-C666131

Antibody:

HIC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$351

Select

HIC1 Antibody LS-C411184

Antibody:

HIC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

Select

HIC1 Antibody (aa498-527) LS-C321948

Antibody:

HIC1 Rabbit anti-Human Polyclonal (aa498-527) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

HIC1 Antibody (aa498-527, Biotin) LS-C258452

Antibody:

HIC1 Rabbit anti-Human Polyclonal (aa498-527) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

HIC1 Antibody (aa498-527, FITC) LS-C258453

Antibody:

HIC1 Rabbit anti-Human Polyclonal (aa498-527) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

HIC1 Antibody (aa498-527, APC) LS-C258451

Antibody:

HIC1 Rabbit anti-Human Polyclonal (aa498-527) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

HIC1 Antibody (aa498-527, Azide-free, HRP) LS-C258454

Antibody:

HIC1 Rabbit anti-Human Polyclonal (aa498-527) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

HIC1 Antibody (aa498-527, PE) LS-C258455

Antibody:

HIC1 Rabbit anti-Human Polyclonal (aa498-527) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

HIC1 Antibody (aa396-410) LS-C186512

Antibody:

HIC1 Goat anti-Human Polyclonal (aa396-410) Antibody

Reactivity:

Dog, Bovine, Hamster, Pig, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$454

Select

HIC1 Antibody (aa193-204) LS-C186511

Antibody:

HIC1 Goat anti-Human Polyclonal (aa193-204) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

Select

HIC1 Antibody LS-C767159

Antibody:

HIC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

HIC1 Antibody (aa899-948) LS-C110323

Antibody:

HIC1 Rabbit anti-Human Polyclonal (aa899-948) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

HIC1 Antibody (aa899-948, Biotin) LS-C437569

Antibody:

HIC1 Rabbit anti-Human Polyclonal (aa899-948) (Biotin) Antibody

Reactivity:

Dog, Guinea pig, Bovine, Pig, Horse, Bat, Human, Monkey, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

• Unconjugated
• Biotin

• Unconjugated
• Biotin

Select

HIC1 Antibody (aa215-264) LS-C109624

Antibody:

HIC1 Rabbit anti-Human Polyclonal (aa215-264) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

HIC1 Antibody (aa215-264, HRP) LS-C427068

Antibody:

HIC1 Rabbit anti-Human Polyclonal (aa215-264) (HRP) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Bat, Human, Monkey

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

HIC1 Antibody (aa215-264, Biotin) LS-C427066

Antibody:

HIC1 Rabbit anti-Human Polyclonal (aa215-264) (Biotin) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Bat, Human, Monkey

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

HIC1 Antibody (aa215-264, FITC) LS-C427067

Antibody:

HIC1 Rabbit anti-Human Polyclonal (aa215-264) (FITC) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Bat, Human, Monkey

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

HIC1 Antibody (aa498-527) LS-C166863

Antibody:

HIC1 Rabbit anti-Human Polyclonal (aa498-527) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

HIC1 Antibody LS-C833191

Antibody:

HIC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

HIC1 Antibody LS-C748927

Antibody:

HIC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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