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Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Gene Name: | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 |
Synonyms: | HERC1, p619, p532 |
Target Sequences: | NM_003922 NP_003913.3 Q15751 |
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