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HDGFRP2 encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants.
Gene Name: | hepatoma-derived growth factor-related protein 2 |
Synonyms: | HDGFRP2, HDGF-2, HDGF2, HRP-2 |
Target Sequences: | NM_032631 AAH00755.1 Q7Z4V5 |
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