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HCK

hemopoietic cell kinase

Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.

Gene Name: hemopoietic cell kinase
Family/Subfamily: Protein Kinase , Src
Synonyms: HCK, Hematopoietic cell kinase, Hemopoietic cell kinase, JTK9, Hck kinase, p59Hck, Tyrosine-protein kinase HCK, p59-hck, p61Hck, p60-hck
Target Sequences: NM_002110 NP_002101.2 P08631

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Products
Antibodies (79)
Primary (79)
HCK (79)
Human (71)
Mouse (42)
Rat (13)
Chimpanzee (3)
Monkey (3)
IHC (19)
IHC-P (4)
WB (73)
Flo (6)
ELISA (36)
ICC (1)
IF (11)
IP (1)
Peptide-ELISA (3)
rabbit (66)
mouse (12)
rat (1)
Product Group
IHCPlus (1)
IgG (41)
IgG1 (3)
IgG1,k (2)
IgG2a (1)
IgG2a,k (6)
monoclonal mc (12)
polyclonal pc (67)
1508CT602.13.1 (1)
1D9-1A9 (1)
3D12E10 (2)
APC (2)
APC Conjugated (7)
Azide-free (3)
Biotin Conjugated (8)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (8)
HRP Conjugated (8)
PE Conjugated (7)
Unconjugated (37)
aa2-524 (8)
aa2-526 (8)
aa1-30 (7)
aa131-156 (7)
aa72-101 (7)
aa295-344 (4)
350-430 aa (2)
pTyr410 (2)
450-530 aa (1)
aa1-220 (1)
aa1-80 (1)
aa22-80 (1)
aa381-430 (1)
pTyr521 (1)
No (79)
HCK Antibody - HCK Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human spleen tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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HCK Rabbit anti-Human Polyclonal (aa131-156) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
HCK Antibody - Mouse Hck Antibody western blot of CEM cell line lysates (35 ug/lane). The Hck antibody detected the Hck protein (arrow).
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HCK Rabbit anti-Mouse Polyclonal (aa72-101) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$393
HCK Antibody - IHC of paraffin-embedded human colon cancer (left) and pancreas cancer (right), showing cytoplasmic localization using HCK mouse monoclonal antibody with DAB staining.
Select
HCK Mouse anti-Human Monoclonal (3D12E10) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µl/$467
Select
HCK Rabbit anti-Human Polyclonal (450-530 aa) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Select
HCK Rat anti-Human Monoclonal (aa22-80) Antibody
Mouse, Human
WB
Unconjugated
100 µg/$896
HCK Antibody - Western blot of Hck antibody
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HCK Rabbit anti-Human Polyclonal (350-430 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Select
HCK Rabbit anti-Human Polyclonal (aa131-156) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
Select
HCK Rabbit anti-Human Polyclonal (aa131-156) (Biotin) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
Select
HCK Rabbit anti-Human Polyclonal (aa131-156) (FITC) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
Select
HCK Rabbit anti-Human Polyclonal (aa131-156) (APC) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
Select
HCK Rabbit anti-Human Polyclonal (aa131-156) (PE) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
Select
HCK Rabbit anti-Human Polyclonal (aa131-156) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
HCK Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HCK Rabbit anti-Human Polyclonal (aa295-344) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
Select
HCK Rabbit anti-Human Polyclonal (350-430 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
HCK Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using HCK antibody.
Select
HCK Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC
Unconjugated
100 µg/$357
HCK Antibody - Immunofluorescence analysis of A549 cells.
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HCK Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
Select
HCK Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
HCK Antibody
Select
HCK Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, WB
Unconjugated
50 µl/$286; 100 µl/$321
HCK Antibody - Immunohistochemistry analysis of paraffin-embedded human brain tissue, using HCK Antibody Antibody. The picture on the right is blocked with the synthesized peptide.
Select
HCK Rabbit anti-Human Polyclonal (aa381-430) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
Select
HCK Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
HCK Antibody - Immunofluorescent analysis of 4% paraformaldehyde-fixed, 0.1% Triton X-100 permeabilized HepG2 (human liver hepatocellular carcinoma cell line) cells labeling Pdx1 with antibody at 1:25 dilution, followed by Dylight 488-conjugated goat anti-mouse IgG secondary antibody at 1:200 dilution (green). Immunofluorescence image showing cytoplasm staining on HepG2 cell line. Cytoplasmic actin is detected with Dylight 554 Phalloidin (PD18466410) at 1:100 dilution (red). The nuclear counter stain is DAPI (blue).
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HCK Mouse anti-Human Monoclonal (1508CT602.13.1) Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
200 µl/$393
HCK Antibody - Immunohistochemistry of paraffin-embedded human tonsil using antibody at 1:100 dilution.
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HCK Rabbit anti-Human Polyclonal (aa1-220) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
HCK Antibody - Western Blot analysis of HCK expression in transfected 293T cell line by HCK monoclonal antibody (M01), clone 1D9-1A9.Lane 1: HCK transfected lysate (Predicted MW: 57.3 KDa).Lane 2: Non-transfected lysate.
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HCK Mouse anti-Human Monoclonal (1D9-1A9) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$423
HCK Antibody - HCK Antibody in Immunohistochemistry (IHC)
Select
HCK Mouse anti-Human Monoclonal (3D12E10) Antibody
Human
IHC, WB
Unconjugated
100 µl/$518
Select
HCK Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).