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HAVCR2 / TIM-3

hepatitis A virus cellular receptor 2

HAVCR2 / TIM-3 belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.

Gene Name: hepatitis A virus cellular receptor 2
Synonyms: HAVCR2, HAVcr-2, KIM-3, Kidney injury molecule-3, T cell immunoglobulin mucin 3, Tim-3, TIMD3, T-cell membrane protein 3, TIM3, TIMD-3, T cell immunoglobulin mucin-3, CD366
Target Sequences: NM_032782 NP_116171.3 Q8TDQ0

Publications (3)

1
TIM-3 expression in lymphoma cells predicts chemoresistance in patients with adult T-cell leukemia/lymphoma. Horlad H, Ohnishi K, Ma C, Fujiwara Y, Niino D, Ohshima K, Jinushi M, Matsuoka M, Takeya M, Komohara Y. Oncology letters. 2016 12:1519-1524. (WB; Human) [Full Text Article] [PubMed:27446463] [PMC:PMC4950894] Related Antibodies: LS-C55594.
2
Progression of benign prostatic hyperplasia is associated with pro-inflammatory mediators and chronic activation of prostate-infiltrating lymphocytes. Norström MM, Rådestad E, Sundberg B, Mattsson J, Henningsohn L, Levitsky V, Uhlin M. Oncotarget. 2016 7:23581-93. (Flo, ELISA; Human) [Full Text Article] [PubMed:26993768] [PMC:PMC5029649] Related Antibodies: LS-C107052.
3
Identification and characterization of M6903, an antagonistic anti-TIM-3 monoclonal antibody. Dong Zhang, Feng Jiang, Rinat Zaynagetdinov, Hui Huang, Vanita D Sood, Hong Wang, Xinyan Zhao, Molly H Jenkins, Qingyong Ji, Youbin Wang, David P Nannemann, Djordje Musil, John Wesolowski, Andrea Paoletti, Tin Bartholomew, Melissa G Derner, Qi An, Christel Iffland, Joern-Peter Halle. Oncoimmunology. 2020 Apr;9:1744921. [Full Text Article] [PubMed:32313722] [PMC:PMC7153820] Related Antibodies: LS-C748494.

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HAVCR2 / TIM-3 Antibody - Staining of non-polarized (left) or Th1-polarized (right) normal human peripheral blood cells with FITC anti-human CD4 (RPA-T4) (LS-C106503) and APC anti-human TIM-3 (TIM3). Total viable cells were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HAVCR2 / TIM-3 Mouse anti-Human Monoclonal (APC) (F38-2E2) Antibody
Human
Flo
APC Conjugated
25 Tests/$315; 100 Tests/$442
HAVCR2 / TIM-3 Antibody - Anti-HAVCR2 / TIM-3 antibody IHC of human spleen, lymphocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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HAVCR2 / TIM-3 Rabbit anti-Human Polyclonal (aa176-194) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$495
HAVCR2 / TIM-3 Antibody - Tim-3 transfected LY5178Y cells stained with Rat anti-Mouse TIM-3
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HAVCR2 / TIM-3 Rat anti-Mouse Monoclonal (RMT3-23) Antibody
Mouse
Flo, IF, IHC, IHC-Fr, IHC-P
Unconjugated
0.1 mg/$385
HAVCR2 / TIM-3 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-HAVCR2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min)(1:150).
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HAVCR2 / TIM-3 Mouse anti-Human Monoclonal (aa22-202) (OTI2E2) Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$450
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HAVCR2 / TIM-3 Rat anti-Mouse Monoclonal (25F.1D6) Antibody
Mouse
Flo, IHC
Unconjugated
250 µg/$421
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HAVCR2 / TIM-3 Rat anti-Mouse Monoclonal (FITC) (25F.1D6) Antibody
Mouse
Flo, IHC
FITC Conjugated
100 µg/$369
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HAVCR2 / TIM-3 Mouse anti-Human Monoclonal (GF1) Antibody
Human
Flo, WB
Unconjugated
100 µl/$786
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HAVCR2 / TIM-3 Rat anti-Mouse Monoclonal (RMT3-23) Antibody
Mouse
Flo
Unconjugated
50 µg/$285; 100 µg/$382; 500 µg/$476
HAVCR2 / TIM-3 Antibody - HAVCR2 / TIM 3 antibody Western blot of OVCAR-3 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HAVCR2 / TIM-3 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
HAVCR2 / TIM-3 Antibody - Goat Anti-TIM3 / HAVCR2 Antibody Immunofluorescence analysis of paraformaldehyde fixed HepG2 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing membrane/cytoplasmic and nuclear staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).
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HAVCR2 / TIM-3 Goat anti-Human Polyclonal (aa225-236) Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
100 µg/$503
HAVCR2 / TIM-3 Protein
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E. coli
His, N-Terminal
100 µg/$361; 500 µg/$739; 20 µg/$261
HAVCR2 / TIM-3 Antibody - Tim-3 transfected LY5178Y cells stained with Rat anti-Mouse TIM-3:FITC This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HAVCR2 / TIM-3 Rat anti-Mouse Monoclonal (FITC) (RMT3-23) Antibody
Mouse
Flo
FITC Conjugated
0.1 mg/$432
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
20.86kD
10 µg/$262; 50 µg/$365; 500 µg/$1,585; 1 mg/$2,157
HAVCR2 / TIM-3 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) at 10 µg/ml.
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HAVCR2 / TIM-3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC-P, WB
Unconjugated
0.05 mg/$460
HAVCR2 / TIM-3 Antibody - Western blot analysis of extracts of various cell lines, using HAVCR2 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 15s.
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HAVCR2 / TIM-3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
HAVCR2 / TIM-3 Antibody - Immunohistochemistry of paraffin-embedded human lung cancer tissue.
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HAVCR2 / TIM-3 Rabbit anti-Human Polyclonal (aa22-202) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
HAVCR2 / TIM-3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$834
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HAVCR2 / TIM-3 Mouse anti-Human Monoclonal (2A7A6) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
HAVCR2 / TIM-3 Antibody - FACS: Mouse Tim-3-transfected HEK 293 cells were stained significantly using anti-TIM-3 (mouse), mAb (TI 142F) . No binding was detected on empty vector transfected cells.
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HAVCR2 / TIM-3 Rat anti-Mouse Monoclonal (TI 142F) Antibody
Mouse
ELISA, Flo
Unconjugated
50 µg/$337; 100 µg/$386
HAVCR2 / TIM-3 Antibody - Immunohistochemistry of TIM-3 in human colon carcinoma tissue with TIM-3 antibody at 5 ug/mL.
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HAVCR2 / TIM-3 Mouse anti-Human Monoclonal (2A6) Antibody
Human
ELISA, Flo, ICC, IF, IHC-P, WB
Unconjugated
0.1 mg/$502
HAVCR2 / TIM-3 Antibody - Immunofluorescence analysis of Hela cells using TIM3 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher
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HAVCR2 / TIM-3 Mouse anti-Human Monoclonal (7C8A7) Antibody
Human
ELISA, Flo, ICC, IHC, WB
Unconjugated
100 µl/$459
HAVCR2 / TIM-3 Antibody - Western blot of TIM-3 in A) mouse and B) rat kidney cell lysate using antibody at 2 ug/ml.
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HAVCR2 / TIM-3 Rabbit anti-Mouse Polyclonal (aa100-200) Antibody
Mouse
WB
Unconjugated
0.1 mg/$386
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HAVCR2 / TIM-3 Rat anti-Mouse Monoclonal (aa20-193) (PerCP) (11n191) Antibody
Mouse
Flo
PerCP Conjugated
100 Tests/$907
HAVCR2 / TIM-3 Antibody - Western blot of HAVCR2 / TIM-3 antibody.
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HAVCR2 / TIM-3 Rabbit anti-Human Polyclonal (aa22-202) Antibody
Pig, Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
HAVCR2 / TIM-3 Antibody - Immunohistochemistry of paraffin-embedded mouse liver using HAVCR2 antibody at dilution of 1:100 (40x lens).
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HAVCR2 / TIM-3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Viewing 1-25 of 206 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).