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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Hamartin / TSC1

tuberous sclerosis 1

Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high. Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro, suggesting that the TSC1/TSC2 decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth. A shorter 40 kD isoform of TSC1 has been shown to exist but its function is unknown.

Gene Name: tuberous sclerosis 1
Synonyms: TSC1, LAM, Tuberous sclerosis 1 protein, Tuberous sclerosis 1, Hamartin, KIAA0243, TSC, Tumor suppressor
Target Sequences: NM_000368 NP_000359.1 Q92574

Filtered by: None
Target
Hamartin / TSC1 (306)
Reactivity
Human (169)
Mouse (131)
Rat (52)
Dog (2)
Horse (3)
Monkey (3)
Rabbit (28)
Application
IHC (38)
IHC-Fr (1)
IHC-P (11)
WB (64)
Flo (2)
DB (224)
ELISA (243)
ICC (7)
IF (12)
IP (10)
Peptide-ELISA (1)
Host
rabbit (277)
mouse (28)
goat (1)
Isotype
IgG (241)
IgG1 (10)
IgG2a (6)
IgG2b (11)
Clonality
monoclonal mc (27)
polyclonal pc (279)
Clone
357CT4.4.2 (8)
OTI2B2 (2)
OTI2G3 (2)
OTI3A2 (2)
OTI5A7 (2)
OTI5A8 (2)
TS106 (1)
Format
AP Conjugated (34)
APC Conjugated (33)
Azide-free (32)
Biotin Conjugated (35)
Carrier-free (5)
FITC Conjugated (35)
HRP Conjugated (35)
PE Conjugated (34)
Unconjugated (100)
Epitope
pSer312 (16)
pThr310 (16)
pTyr297 (16)
pTyr304 (16)
aa401-430 (8)
pSer1080 (8)
pSer1130 (8)
pSer1138 (8)
pSer1141 (8)
pSer321 (8)
pSer387 (8)
pSer505 (8)
pSer511 (8)
pSer555 (8)
pSer561 (8)
pSer591 (8)
pSer594 (8)
pSer598 (8)
pSer682 (8)
pThr1043 (8)
pThr390 (8)
pThr416 (8)
pThr417 (8)
pThr519 (8)
pTyr312 (8)
C-Terminus (7)
Ser505 (7)
aa836-1164 (6)
Internal (1)
aa1100-C-term (1)
aa1117-1144 (1)
aa1150-1163 (1)
aa1150-1164 (1)
aa156-300 (1)
aa395-424 (1)
aa686-884 (1)
Publications
No (306)
Showing 1-25 of 306 results

IHC-plus™ Hamartin / TSC1 Antibody LS-B612
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05mg 1mg/ml  $425.00
Anti-TSC1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-TSC1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

IHC-plus™ Hamartin / TSC1 Antibody (clone 357CT4.4.2) LS-B11809
Mouse Monoclonal [clone 357CT4.4.2] (IgG2b) to Human Hamartin / TSC1
Mouse, Human
IHC, IHC-P, WB
Unconjugated
200µl  $425.00
Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)
TSC1 Antibody western blot of mouse brain tissue lysates (35 ug/lane). The TSC1 antibody detected the TSC1 protein (arrow).

IHC-plus™ Hamartin / TSC1 Antibody LS-B1431
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg 1mg/ml  $545.00
Anti-TSC1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-TSC1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

IHC-plus™ Hamartin / TSC1 Antibody LS-B7265
Mouse Monoclonal (IgG1) to Human Hamartin / TSC1
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50µg 0.5mg/ml  $485.00
Anti-TSC1 antibody IHC of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

IHC-plus™ Hamartin / TSC1 Antibody (aa1150-1163) LS-B4456
Goat Polyclonal to Human Hamartin / TSC1
Dog, Rat, Horse, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-TSC1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Anti-TSC1 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.

Hamartin / TSC1 Antibody (aa401-430) LS-C166779
Rabbit Polyclonal to Human Hamartin / TSC1
Human
IF, IHC, IHC-P, WB
Unconjugated
400µl  $325.00
Hamartin (TSC1) Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human skeletal muscle followed by peroxidase-conjugated secondary antibody and DAB staining.This data demonstrates the use of Hamartin (TSC1) Antibody for immunohistochemistry.
Confocal immunofluorescence of Hamartin (TSC1) Antibody with HeLa cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

Hamartin / TSC1 Antibody (phospho-Ser511) LS-C156984
Rabbit Polyclonal to Human Hamartin / TSC1
Human
DB
Unconjugated
400µl  $325.00
Dot blot of TSC1 Antibody (Phospho S511) Phospho-specific antibody on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.

Hamartin / TSC1 Antibody (clone OTI3A2) LS-C175718
Mouse Monoclonal [clone OTI3A2] (IgG2a) to Human Hamartin / TSC1
Human
IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded Human breast tissue using anti-TSC1 mouse monoclonal antibody.
IHC of paraffin-embedded Human colon tissue using anti-TSC1 mouse monoclonal antibody.

Hamartin / TSC1 Antibody (aa836-1164, clone OTI3A2, Carrier-free) LS-C789383
Mouse Monoclonal [clone OTI3A2] (IgG2a) to Human Hamartin / TSC1
Human
IHC, WB
Unconjugated, Carrier-free
100µg  $395.00

Hamartin / TSC1 Antibody (aa1100-C-term) LS-C287234
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Mouse, Human
IP, WB
Unconjugated
100µl 1mg/ml  $395.00

Hamartin / TSC1 Antibody (aa401-430) LS-C321878
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Human
ELISA, IF, IHC, WB
Unconjugated
200µl  $590.00

Hamartin / TSC1 Antibody (aa401-430, Biotin) LS-C259655
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Human
ELISA, ICC, IF, IHC, WB
Biotin Conjugated
200µl  $740.00

Hamartin / TSC1 Antibody (aa401-430, FITC) LS-C259654
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Human
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200µl  $740.00

Hamartin / TSC1 Antibody (aa401-430, AP) LS-C259652
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Human
ELISA, ICC, IF, IHC, WB
AP Conjugated
200µl  $740.00

Hamartin / TSC1 Antibody (aa401-430, APC) LS-C259653
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200µl  $740.00

Hamartin / TSC1 Antibody (aa401-430, PE) LS-C259664
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200µl  $740.00

Hamartin / TSC1 Antibody (aa401-430, Azide-free, HRP) LS-C259656
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Human
ELISA, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200µl  $740.00

Hamartin / TSC1 Antibody LS-C801254
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00

Hamartin / TSC1 Antibody LS-C660277
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100µg  $435.00

Hamartin / TSC1 Antibody (clone OTI5A8) LS-C175719
Mouse Monoclonal [clone OTI5A8] (IgG2b) to Human Hamartin / TSC1
Human
IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded Carcinoma of Human lung tissue using anti-TSC1 mouse monoclonal antibody.
IHC of paraffin-embedded Human lymphoma tissue using anti-TSC1 mouse monoclonal antibody.

Hamartin / TSC1 Antibody (aa836-1164, clone OTI5A8, Carrier-free) LS-C789384
Mouse Monoclonal [clone OTI5A8] (IgG2b) to Human Hamartin / TSC1
Human
IHC, WB
Unconjugated, Carrier-free
100µg  $395.00

Hamartin / TSC1 Antibody LS-C501529
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Human
ELISA, IF, IHC
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human placental tissue using TSC1 Antibody at dilution of 1:100
Immunofluorescent analysis of Hela cells using TSC1 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Hamartin / TSC1 Antibody (aa1150-1164) LS-C313152
Rabbit Polyclonal to Human Hamartin / TSC1
Rat, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µg 200µl 0.5mg/ml  $305.00
Hamartin / TSC1 antibody. IHC(P): Human Breast Cancer Tissue.
Hamartin / TSC1 antibody. IHC(P): Rat Brain Tissue.

Hamartin / TSC1 Antibody LS-C121925
Mouse Monoclonal (IgG1) to Human Hamartin / TSC1
Rat, Human
IHC, IHC-P, WB
Unconjugated
100µl  $605.00

Hamartin / TSC1 Antibody LS-C7330
Rabbit Polyclonal to Human Hamartin / TSC1
Mouse, Rat, Human
Flo, IP, WB
Unconjugated
100µl  $530.00
Showing 1-25 of 306 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).