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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Hamartin / TSC1

tuberous sclerosis 1

Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high. Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro, suggesting that the TSC1/TSC2 decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth. A shorter 40 kD isoform of TSC1 has been shown to exist but its function is unknown.

Gene Name: tuberous sclerosis 1
Synonyms: TSC1, LAM, Tuberous sclerosis 1 protein, Tuberous sclerosis 1, Hamartin, KIAA0243, TSC, Tumor suppressor
Target Sequences: NM_000368 NP_000359.1 Q92574


Hamartin / TSC1 Antibody - Anti-TSC1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $425.00
Hamartin / TSC1 Antibody - Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Mouse Monoclonal [clone 357CT4.4.2] (IgG2b) to Human Hamartin / TSC1
Mouse, Human
IHC, IHC-P, WB
Unconjugated
200µl   $425.00
Hamartin / TSC1 Antibody - Anti-TSC1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $545.00
Hamartin / TSC1 Antibody - Anti-TSC1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
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Goat Polyclonal to Human Hamartin / TSC1
Dog, Rat, Horse, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   0.5mg/ml   $425.00
Hamartin / TSC1 Antibody - Anti-TSC1 antibody IHC of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Mouse Monoclonal (IgG1) to Human Hamartin / TSC1
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50µg   0.5mg/ml   $485.00
Hamartin / TSC1 Antibody - Hamartin (TSC1) Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human skeletal muscle followed by peroxidase-conjugated secondary antibody and DAB staining.This data demonstrates the use of Hamartin (TSC1) Antibody for immunohistochemistry.
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Rabbit Polyclonal to Human Hamartin / TSC1
Human
IF, IHC, IHC-P, WB
Unconjugated
400µl   $325.00
Hamartin / TSC1 Antibody - Dot blot of TSC1 Antibody (Phospho S511) Phospho-specific antibody on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.
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Rabbit Polyclonal to Human Hamartin / TSC1
Human
DB
Unconjugated
400µl   $325.00
Hamartin / TSC1 Antibody - IHC of paraffin-embedded Human breast tissue using anti-TSC1 mouse monoclonal antibody.
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Mouse Monoclonal [clone OTI3A2] (IgG2a) to Human Hamartin / TSC1
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
Hamartin / TSC1 Antibody - IHC of paraffin-embedded Human breast tissue using anti-TSC1 mouse monoclonal antibody.
Select
Mouse Monoclonal [clone OTI3A2] (IgG2a) to Human Hamartin / TSC1
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
Select
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Mouse, Human
IP, WB
Unconjugated
100µl   1mg/ml   $405.00
Hamartin / TSC1 Antibody - 1:200 staining human lung carcinoma tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Human
ELISA, IF, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Human
ELISA, ICC, IF, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Human
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Human
ELISA, ICC, IF, IHC, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Human
ELISA, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100µg   $435.00
Hamartin / TSC1 Antibody - IHC of paraffin-embedded Carcinoma of Human lung tissue using anti-TSC1 mouse monoclonal antibody.
Select
Mouse Monoclonal [clone OTI5A8] (IgG2b) to Human Hamartin / TSC1
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
Hamartin / TSC1 Antibody - IHC of paraffin-embedded Carcinoma of Human lung tissue using anti-TSC1 mouse monoclonal antibody.
Select
Mouse Monoclonal [clone OTI5A8] (IgG2b) to Human Hamartin / TSC1
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
Hamartin / TSC1 Antibody - Immunohistochemistry of paraffin-embedded human placental tissue using TSC1 Antibody at dilution of 1:100
Select
Rabbit Polyclonal (IgG) to Human Hamartin / TSC1
Human
ELISA, IF, IHC
Unconjugated
50µg   $285.00; 100µg   $385.00
Hamartin / TSC1 Antibody - Hamartin / TSC1 antibody. IHC(P): Human Breast Cancer Tissue.
Select
Rabbit Polyclonal to Human Hamartin / TSC1
Rat, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µg   0.5mg/ml   $355.00
Select
Mouse Monoclonal (IgG1) to Human Hamartin / TSC1
Rat, Human
IHC, IHC-P, WB
Unconjugated
100µl   $605.00
Select
Rabbit Polyclonal to Human Hamartin / TSC1
Mouse, Rat, Human
Flo, IP, WB
Unconjugated
100µl   $530.00
Viewing 1-25 of 304 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).