HACE1

HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1

E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

HACE1 (4)

Publications

No (4)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human HACE1 Protein (Recombinant GST, N-terminus) (aa800-909) - LS-G62967

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human HACE1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70407

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

102.2 kDa

Price:

20 µg/$1,107

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HACE1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G111009

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

102.2 kDa

Price:

100 µg/$494

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Human HACE1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87017

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

102.2 kDa

Price:

20 µg/$150

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