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Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box.
Gene Name: | general transcription factor IIIC, polypeptide 4, 90kDa |
Synonyms: | GTF3C4, KAT12, TF3C-delta, TFIIIC 90 kDa subunit, TFIII90, TFIIIC290, TFIIIC90, TFIIICDELTA |
Target Sequences: | NM_012204 NP_036336.2 Q9UKN8 |
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