GTF2H2

general transcription factor IIH, polypeptide 2, 44kDa

GTF2H2 is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

GTF2H2 (3)

Publications

No (3)

Tag

GST (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Purified (1)

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GTF2H2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118538

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.2 kDa

Price:

100 µg/$494

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Human GTF2H2 Protein (Recombinant GST) (Full Length) - LS-G28756

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

43.89 kDa

Price:

10 µg/$479; 25 µg/$670

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Human GTF2H2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74713

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.2 kDa

Price:

20 µg/$150

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