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GTF2A1L / ALF
general transcription factor IIA, 1-like
The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of transcription factor IIA (TFIIA) on the interaction between TATA-binding protein (TBP) and DNA. This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct isoforms, have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
| Gene Name: | general transcription factor IIA, 1-like |
| Synonyms: | GTF2A1L, ALF, GTF2A1-like factor, GTF2A1LF, TFIIA-alpha/beta-like factor |
| Target Sequences: | NM_006872 NP_006863.2 Q9UNN4 |
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