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GSTP1 / GST Pi

glutathione S-transferase pi 1

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.

Gene Name: glutathione S-transferase pi 1
Synonyms: GSTP1, Deafness, X-linked 7, DFN7, GSTP1-1, Glutathione S-transferase P, GST Pi, GSTP, FAEES3, Glutathione S-transferase pi 1, GST class-pi, GST3, PI
Target Sequences: NM_000852 NP_000843.1 P09211

Publications (5)

1
Caloric restriction delays early phases of carcinogenesis via effects on the tissue microenvironment. Cadoni E, Marongiu F, Fanti M, Serra M, Laconi E. Oncotarget. 2017 8:36020-36032. (WB; Rat) [Full Text Article] [PubMed:28415598] [PMC:PMC5482635]
2
Editor's Highlight: Glutathione S-Transferase Activity Moderates Methylmercury Toxicity During Development in Drosophila. Vorojeikina D, Broberg K, Love TM, Davidson PW, van Wijngaarden E, Rand MD. Toxicological sciences : an official journal of the Society of Toxicology. 2017 May;157:211-221. (Human) [Full Text Article] [PubMed:28184905] [PMC:PMC5837650] Related Antibodies: LS-B2376.
3
Fractionation enhances acute oligodendrocyte progenitor cell radiation sensitivity and leads to long term depletion. Begolly S, Olschowka JA, Love T, Williams JP, O'Banion MK. Glia. 2018 April;66:846-861. [Full Text Article] [PubMed:29288597] [PMC:PMC5812816] Related Antibodies: LS-B2376.
4
Erratic and blood vessel-guided migration of astrocyte progenitors in the cerebral cortex. Hidenori Tabata, Megumi Sasaki, Masakazu Agetsuma, Hitomi Sano, Yuki Hirota, Michio Miyajima, Kanehiro Hayashi, Takao Honda, Masashi Nishikawa, Yutaka Inaguma, Hidenori Ito, Hirohide Takebayashi, Masatsugu Ema, Kazuhiro Ikenaka, Junichi Nabekura, Koh-Ichi Nagata, Kazunori Nakajima. Nature communications. 2022 November;13:6571. [Full Text Article] [PubMed:36323680] [PMC:PMC9630450] Related Antibodies: LS-B2376.
5
Integrated hepatic transcriptome and proteome analysis of mice with high-fat diet-induced nonalcoholic fatty liver disease. Kirpich IA, Gobejishvili LN, Bon Homme M, Waigel S, Cave M, Arteel G, Barve SS, McClain CJ, Deaciuc IV. The Journal of nutritional biochemistry. 2011 Jan;22:38-45. [Full Text Article] [PubMed:20303728] [PMC:PMC3860361] Related Antibodies: LS-B2376.
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).