GSK3A / GSK3 Alpha

glycogen synthase kinase 3 alpha

Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.

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Products

ELISA Kits (25)

Type

Cell-Based (2)

Cell-Based Phosphorylation (2)

Competitive EIA (1)

Custom (2)

Sandwich (15)

Sandwich CLIA (3)

Target

GSK3A / GSK3 Alpha (25)

Reactivity

Human (10)

Mouse (8)

Rat (10)

Chicken (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Sheep (1)

Format

12 x 8-Well Microstrips (3)

96-Well Microplate (7)

96-Well Strip Plate (15)

Publications

No (25)

Sample Type

Adherent Cell Cultures (4)

Plasma (12)

Serum (12)

Tissue Homogenates (5)

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Chicken GSK3A / GSK3 Alpha (Sandwich ELISA) ELISA Kit - LS-F44495

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Porcine GSK3A / GSK3 Alpha (Sandwich ELISA) ELISA Kit - LS-F44497

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Monkey GSK3A / GSK3 Alpha (Sandwich ELISA) ELISA Kit - LS-F44496

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Rabbit GSK3A / GSK3 Alpha (Sandwich ELISA) ELISA Kit - LS-F44498

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Sheep GSK3A / GSK3 Alpha (Sandwich ELISA) ELISA Kit - LS-F44499

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Sheep

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$760

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Mouse GSK3A / GSK3 Alpha (Custom ELISA) ELISA Kit - LS-F15181

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$685

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Human GSK3A / GSK3 Alpha (Custom ELISA) ELISA Kit - LS-F15182

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$685

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Human GSK3A / GSK3 Alpha (Sandwich ELISA) ELISA Kit - LS-F21199

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Mouse GSK3A / GSK3 Alpha (Sandwich ELISA) ELISA Kit - LS-F24171

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

7.813 - 500 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Human GSK3A / GSK3 Alpha (CLIA) ELISA Kit - LS-F30190

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

Select

Mouse GSK3A / GSK3 Alpha (CLIA) ELISA Kit - LS-F30730

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

3.125 - 200 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

Select

Human GSK3A / GSK3 Alpha (Sandwich ELISA) ELISA Kit - LS-F28798

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.5 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

Select

Rat GSK3A / GSK3 Alpha (Sandwich ELISA) ELISA Kit - LS-F22642

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Rat GSK3A / GSK3 Alpha (CLIA) ELISA Kit - LS-F37569

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Rat

Range:

125 - 8000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

Select

Rat GSK3A / GSK3 Alpha (Competitive EIA) ELISA Kit - LS-F27973

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

2.5 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

Select

Mouse GSK3A / GSK3 Alpha (Sandwich ELISA) ELISA Kit - LS-F37492

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

7.813 - 500 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat GSK3A / GSK3 Alpha (Sandwich ELISA) ELISA Kit - LS-F33037

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human GSK3A / GSK3 Alpha (Sandwich ELISA) ELISA Kit - LS-F36739

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat GSK3A / GSK3 Alpha (Sandwich ELISA) ELISA Kit - LS-F4364

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$818

Select

Human GSK3A / GSK3 Alpha (Sandwich ELISA) ELISA Kit - LS-F4363

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$764

Select

Rat GSK3A / GSK3 Alpha (Sandwich ELISA) ELISA Kit - LS-F11583

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$685

Select

Mouse/Human/Rat Phospho-GSK3A / GSK3 Alpha (Ser21) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1520

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

Select

Mouse/Human/Rat Phospho-GSK3A / GSK3 Alpha (Tyr279/216) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1040

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

Select

Mouse/Human/Rat GSK3A / GSK3 Alpha (Cell-Based ELISA) ELISA Kit - LS-F2029

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

Select

Mouse/Human/Rat GSK3A / GSK3 Alpha (Cell-Based ELISA) ELISA Kit - LS-F2030

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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