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GS28 / GOSR1 / p28
golgi SNAP receptor complex member 1
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
| Gene Name: | golgi SNAP receptor complex member 1 |
| Synonyms: | GOSR1, 28 kDa cis-Golgi SNARE p28, 28 kDa Golgi SNARE protein, Golgi SNARE 28 kDa, GOS-28, GOS28, Cis-golgi SNARE, GOLIM2, GS28, p28 |
| Target Sequences: | NM_004871 NP_004862.1 O95249 |
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