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GRIN1 / NMDAR1

glutamate receptor, ionotropic, N-methyl D-aspartate 1

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's disease, epilepsy and ischemic neuronal cell death. Increased membrane surface expression of the NR1 subunit of the receptor has been associated with synaptic plasticity.

Gene Name: glutamate receptor, ionotropic, N-methyl D-aspartate 1
Family/Subfamily: Ion Channel , Glutamate receptor - ionotropic (NMDA receptor)
Synonyms: GRIN1, GluN1, NMDAR1, NR1, MRD8, NMD-R1, NMDA receptor A1, NMDA1, NR1a, GluR zeta 1, N-methyl-D aspartate receptor
Target Sequences: NM_007327 NP_015566.1 Q05586

Publications (2)

1
REST-Governed Gene Expression Profiling in a Neuronal Cell Model Reveals Novel Direct and Indirect Processes of Repression and Up-Regulation. Garcia-Manteiga JM, Bonfiglio S, Folladori L, Malosio ML, Lazarevic D, Stupka E, Cittaro D, Meldolesi J. Frontiers in cellular neuroscience. 2015 9:438. (WB; Human) [Full Text Article] [PubMed:26617488] [PMC:PMC4639699] Related Antibodies: LS-B7013.
2
Direct binding of Toll-like receptor 4 to ionotropic glutamate receptor N-methyl-D-aspartate subunit 1 induced by lipopolysaccharide in microglial cells N9 and EOC 20. Cui J, Yu S, Li Y, Li P, Liu F. International journal of molecular medicine. 2018 March;41:1323-1330. (Human) [Full Text Article] [PubMed:29286078] [PMC:PMC5819937] Related Antibodies: LS-B13901.

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Products
Proteins (9)
Over-Expression Lysate (4)
Recombinant (5)
GRIN1 / NMDAR1 (9)
No (9)
6His, N-terminus (1)
DDK,C-terminus (1)
GST, N-terminus (1)
Myc-DDK (Flag) (6)
Human (7)
293T Cells (2)
CHO Cells (1)
E. coli (1)
HEK 293 Cells (4)
Wheat Germ Extract (1)
Purified (1)
GRIN1 / NMDAR1 Protein - Purified recombinant protein GRIN1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
97.3 kDa
20 µg/$1,107
GRIN1 / NMDAR1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His, N-terminus
64.6 kDa
20 µg/$405; 1 mg/$1,679; 100 µg/$598
GRIN1 / NMDAR1 Protein - Purified recombinant protein GRIN1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
103.4 kDa
20 µg/$1,107
GRIN1 / NMDAR1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
99.31 kDa
100 µg/$710
GRIN1 / NMDAR1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
2 µg/$439
GRIN1 / NMDAR1 Protein
Select
CHO Cells
DDK,C-terminus
61.2 kDa
50 µg/$677
GRIN1 / NMDAR1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
99.31 kDa
20 µg/$215
GRIN1 / NMDAR1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
105.37 kDa
20 µg/$215
GRIN1 / NMDAR1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
105.37 kDa
100 µg/$710
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).