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GRIA3 / GLUR3

glutamate receptor, ionotropic, AMPA 3

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Gene Name: glutamate receptor, ionotropic, AMPA 3
Family/Subfamily: Ion Channel , Glutamate receptor - ionotropic (NMDA receptor)
Synonyms: GRIA3, AMPA 3, Glutamate receptor 3, Glutamate receptor C, GLUR-C, GLUR3, GLURC, Glutamate receptor subunit 3, DJ1171F9.1, GluA3, GluR-3, GLUR-K3, MRX94
Target Sequences: NM_000828 NP_000819.3 P42263

Publications (1)

1
Glutamate can act as a signaling molecule in mouse preimplantation embryos. Alexandra Špirková, Veronika Kovaríková, Zuzana Šefcíková, Jozef Pisko, Martina Kšinanová, Juraj Koppel, Dušan Fabian, Štefan Cikoš. Biology of reproduction. 2022 June; [Full Text Article] [PubMed:35746896] Related Antibodies: LS-C331307.

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Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
GRIA3 / GLUR3 (7)
No (7)
GST (1)
GST, N-terminus (1)
His (1)
His-SUMO (1)
His-T7, N-terminus (1)
Myc-DDK (Flag) (2)
Human (6)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Yeast (1)
Purified (1)
GRIA3 / GLUR3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
101.23 kDa
100 µg/$710
GRIA3 / GLUR3 Protein
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Yeast
His
13.98 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
GRIA3 / GLUR3 Protein
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E. coli
His-SUMO
27.97 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
GRIA3 / GLUR3 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
GRIA3 / GLUR3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
101.23 kDa
20 µg/$215
GRIA3 / GLUR3 Protein - Recombinant Glutamate Receptor, Ionotropic, AMPA 3 (GRIA3) by SDS-PAGE
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E. coli
His-T7, N-terminus
22.9kDa
10 µg/$259; 50 µg/$331; 200 µg/$602; 100 µg/$482; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
GRIA3 / GLUR3 Protein - 12.5% SDS-PAGE of human GRIA3 stained with Coomassie Blue
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Wheat Germ Extract
GST
42.5 kDa
10 µg/$479; 25 µg/$670
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).