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GRG4 / TLE4

transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression.

Gene Name: transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
Synonyms: TLE4, BCE1, BCE-1, E(spI), Enhancer of split groucho 4, ESG, ESG4, GRG4, Protein BCE-1, KIAA1261, R-esp2, B lymphocyte gene 1
Target Sequences: NM_007005 NP_008936.2 Q04727

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GRG4 / TLE4 ELISA Kit
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).