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GPX4 / MCSP

glutathione peroxidase 4

GPX4 / MCSP is a member of the glutathione peroxidase protein family. Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. The encoded protein has been identified as a moonlighting protein based on its ability to serve dual functions as a peroxidase as well as a structural protein in mature spermatozoa. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. Alternative splicing results in multiple transcript variants.

Gene Name: glutathione peroxidase 4
Synonyms: GPX4, GPx-4, MCSP, SnPHGPx, Phospholipid hydroperoxidase, SnGPx, Glutathione peroxidase 4, GSHPx-4, PHGPx
Target Sequences: NM_002085 NP_002076.2 P36969

Publications (6)

1
SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress. Papp LV, Lu J, Bolderson E, Boucher D, Singh R, Holmgren A, Khanna KK. Antioxidants & redox signaling. 2010 12:797-808. (WB) [PubMed:19803747] Related Antibodies: LS-B3246.
2
Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans. Schoenmakers E, Agostini M, Mitchell C, Schoenmakers N, Papp L, Rajanayagam O, Padidela R, Ceron-Gutierrez L, Doffinger R, Prevosto C, Luan J, Montano S, Lu J, Castanet M, Clemons N, Groeneveld M, Castets P, Karbaschi M, Aitken S, Dixon A, Williams J, Cam. The Journal of clinical investigation. 2010 120:4220-35. [PubMed:21084748] [PMC:PMC2993594] Related Antibodies: LS-B3246.
3
Epidermal Cells Expressing Putative Cell Markers in Nonglabrous Skin Existing in Direct Proximity with the Distal End of the Arrector Pili Muscle. Torkamani N, Rufaut NW, Jones L, Sinclair R. Stem cells international. 2016 2016:1286315. (IHC; Mouse) [Full Text Article] [PubMed:27375744] [PMC:PMC4916308] Related Antibodies: LS-B1596.
4
Selenium deficiency induces spleen pathological changes in pigs by decreasing selenoprotein expression, evoking oxidative stress, and activating inflammation and apoptosis. Shuang Li , Wenjuan Sun , Kai Zhang, Jiawei Zhu, Xueting Jia, Xiaoqing Guo, Qingyu Zhao, Chaohua Tang, Jingdong Yin, Junmin Zhang. Journal of animal science and biotechnology. 2021 May;12:65. [Full Text Article] [PubMed:33993883] [PMC:PMC8127211]
5
Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke. Ishraq Alim, Joseph T Caulfield, Yingxin Chen, Vivek Swarup, Daniel H Geschwind, Elena Ivanova, Javier Seravalli, Youxi Ai, Lauren H Sansing, Emma J Ste Marie, Robert J Hondal, Sushmita Mukherjee, John W Cave, Botir T Sagdullaev, Saravanan S Karuppagounder, Rajiv R Ratan. Cell. 2019 May;177:1262-1279e25. [Full Text Article] [PubMed:31056284] Related Antibodies: LS-B14362, LS-B1596.
6
HIF1a stabilization in hypoxia is not oxidant-initiated. Amit Kumar, Manisha Vaish, Saravanan S Karuppagounder, Irina Gazaryan, John W Cave, Anatoly A Starkov, Elizabeth T Anderson, Sheng Zhang, John T Pinto, Austin M Rountree, Wang Wang, Ian R Sweet, Rajiv R Ratan. eLife. 2021 October;10:e72873. [Full Text Article] [PubMed:34596045] [PMC:PMC8530508] Related Antibodies: LS-B1596.
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Proteins (5)
Over-Expression Lysate (2)
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GPX4 / MCSP (5)
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6His-SUMO, N-terminus (1)
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His-T7 (1)
Myc-DDK (Flag) (2)
Human (2)
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E. coli (3)
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GPX4 / MCSP Protein - Recombinant Glutathione Peroxidase 4 By SDS-PAGE
Select
E. coli
His-T7
18.1 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
GPX4 / MCSP Protein - Recombinant Glutathione Peroxidase 4 By SDS-PAGE
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E. coli
His-GST
46.2 kDa
10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198
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HEK 293 Cells
Myc-DDK (Flag)
22.1 kDa
100 µg/$494
GPX4 / MCSP Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
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293T Cells
Myc-DDK (Flag)
22.1 kDa
20 µg/$150
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).