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Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.
Gene Name: | G-protein signaling modulator 1 |
Synonyms: | GPSM1, AGS3 homolog, DKFZP727I051, AGS3 |
Target Sequences: | NM_015597 NP_056412.5 Q86YR5 |
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