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GPS2 is a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.
Gene Name: | G protein pathway suppressor 2 |
Synonyms: | GPS2, AMF-1, G protein pathway suppressor 2, GPS-2 |
Target Sequences: | NM_004489 NP_004480.1 Q13227 |
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